A5033042205- Birth, Development, and Health
- Health, Medicine and Society
- Pregnancy and preeclampsia studies
- Healthcare Systems and Practices
- Pediatric Pain Management Techniques
- Gestational Diabetes Research and Management
- Aging, Elder Care, and Social Issues
- Infant Nutrition and Health
- Diet and metabolism studies
- Pharmacological Effects and Toxicity Studies
- Pneumonia and Respiratory Infections
- Kawasaki Disease and Coronary Complications
- Systemic Lupus Erythematosus Research
- Infective Endocarditis Diagnosis and Management
- Bacterial Infections and Vaccines
- Cardiovascular Issues in Pregnancy
- Infant Development and Preterm Care
- Respiratory viral infections research
- Hormonal and reproductive studies
- Social Sciences and Governance
- Hemoglobinopathies and Related Disorders
- Ocular Diseases and Behçet’s Syndrome
- Congenital Anomalies and Fetal Surgery
- Apelin-related biomedical research
- Healthcare Decision-Making and Restraints
University of Lausanne
2018-2023
University Hospital of Lausanne
2018-2023
Hôpital de l'enfance
2018-2020
Sorbonne Université
2010-2015
Hôpital Armand-Trousseau
2010-2015
Assistance Publique – Hôpitaux de Paris
2008-2013
Hôpital d'Enfants
2008-2012
Bicêtre Hospital
2009
Inserm
2009
Université Paris Cité
2006-2008
Because precocious pubarche (PP) reveals late-onset congenital adrenal hyperplasia (LO-CAH) in 5 to 20% of cases, an stimulation test is recommended all patients presenting with it. This stressful and expensive, results are normal more than 80% cases.Our objective was identify clinical plasma predictors LO-CAH among PP.We conducted a retrospective cohort study that included seen for PP at our hospital between 1999 2006 (n = 238). All had undergone ACTH test.LO-CAH defined by post-ACTH...
Intrauterine growth restriction (IUGR) affects 10-15% of all pregnancies worldwide. IUGR may result from maternal, placental or fetal origin. Maternal malnutrition before and during pregnancy represents the most prevalent non-genetic cause. reflects an abnormal adaptive in a deleterious environment. Individuals born after are more susceptible to develop diseases related subsequent stressors through lifetime. Animal models help decipher underlying causes dysregulated pathways molecular...
Metabolic syndrome (MetS) refers to cardiometabolic risk factors, such as visceral obesity, dyslipidemia, hyperglycemia/insulin resistance, arterial hypertension and non-alcoholic fatty liver disease (NAFLD). Individuals born after intrauterine growth restriction (IUGR) are particularly at of developing metabolic/hepatic disorders later in life. Oxidative stress cellular senescence have been associated with MetS observed infants following IUGR. However, whether these mechanisms could be the...
Early nutrition influences the risk of chronic kidney diseases (CKDs) development in adulthood. Mechanisms underlying early programming altered renal function remain incompletely understood. This study aims at characterizing role cell senescence pathways CKD after transient postnatal overfeeding.Reduced litters 3 mice pups and standard 9 were obtained to induce overfed animals during lactation control animals, respectively. Animals sacrificed 24 days (weaning) or 7 months life (adulthood)....
Abstract Early malnutrition, the first environmental cause of intra-uterine growth restriction, impairs development thymus. Alterations thymic structure and function are reported at young ages in murine ovine models. However, descriptions consequences fetal malnutrition adulthood scarce. The present study investigates structure, protein expression cell selection process observed postnatal day 180 (PND180) male offspring rats exposed to maternal low-protein diet (mLPD) compared with control...
Infants born after intrauterine growth restriction (IUGR) are at risk of developing arterial hypertension adulthood. The endothelium plays a major role in the pathogenesis hypertension. Endothelial colony-forming cells (ECFCs), critical circulating components endothelium, involved vasculo-and angiogenesis and repair. We previously described impaired functionality ECFCs cord blood low-birth-weight newborns. However, whether early ECFC alterations persist thereafter could be associated with...
Epidemiological and experimental studies have shown that the peri-conception period, pregnancy, infancy are windows of particular sensibility to environmental clues which influence lifelong trajectories across health disease. Nutrition, stress, toxins induce epigenetic marks control long-term gene expression patterns can be transmitted transgenerationally. Chronic diseases adulthood such as hypertension, diabetes, obesity thus early, developmental origins in perinatal period. The early...
We report an 11-year-old girl with a 3-month history of extended cutaneous leishmaniasis caused by Leishmania major. Oral fluconazole treatment resulted in complete resolution. This result suggests that oral might be alternative to pentavalent antimony lesions L.
Die Adoleszenz ist eine Zeit der Entwicklung und des Wachstums, die das Auftreten funktioneller Störungen begünstigt. Letztere können sich mit einer Vielzahl von Symptomen manifestieren, unterschiedliche Organsysteme betreffen. Am häufigsten treten Kopfschmerzen, Bauchschmerzen Schmerzen am Bewegungsapparat auf.
L'adolescence est une période de développement et croissance propice à l’émergence troubles fonctionnels. Ces derniers peuvent se manifester avec diversité symptômes affectant différents systèmes du corps dont les plus fréquents sont céphalées, douleurs abdominales musculo-squelettiques. Parmi critères diagnostiques l’on retrouve des investigations somatiques approfondies sans cause organique identifiée ainsi qu’un fort impact sur le fonctionnement l’adolescent dans ou plusieurs sphères sa vie.
No abstract available.