A5072648140- Vector-borne infectious diseases
- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- Rabies epidemiology and control
- Microbial infections and disease research
- Toxin Mechanisms and Immunotoxins
- Peptidase Inhibition and Analysis
- Plant Virus Research Studies
- Cardiac electrophysiology and arrhythmias
- Alzheimer's disease research and treatments
- Mosquito-borne diseases and control
- Protease and Inhibitor Mechanisms
- Insect and Pesticide Research
- DNA and Nucleic Acid Chemistry
- Cancer, Hypoxia, and Metabolism
- Virology and Viral Diseases
- Nuclear Receptors and Signaling
- Developmental Biology and Gene Regulation
- Pineapple and bromelain studies
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Pulmonary Hypertension Research and Treatments
- Congenital heart defects research
- Algal biology and biofuel production
École Nationale Vétérinaire d'Alfort
2020-2025
Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
2021-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2025
Département Santé Animale
2024
Bipar
2017-2024
Adaptation Biologique et Vieillissement
2014-2024
Paris-Est Sup
2018
Institut National de la Recherche Agronomique du Niger
2018
Sorbonne Université
2012-2015
Centre National de la Recherche Scientifique
2014-2015
Recent zoonotic disease emergences reveal the importance of studying wildlife parasite communities. As wild hosts frequently harbour diverse species, understanding drivers multiple infection patterns in free-ranging is critical for elucidating ecological and epidemiological dynamics In this study, we analysed co-infection European roe deer (Capreolus capreolus) inhabiting a fragmented rural landscape southwestern France. Using data from 130 GPS-tracked deer, examined influence proximity to...
Ticks transmit a variety of pathogens that affect both animal and human health, underscoring the importance understanding diversity transmission dynamics. The European hedgehog (Erinaceus europaeus) serves as host for ticks such Ixodes hexagonus ricinus, potentially playing role in enzootic cycle tick-borne diseases. This study aimed to evaluate use hedgehogs sentinels monitoring urban suburban areas. A total 251 were involved study, conducted between 2019 2021, with 144 examined 110...
Effects of a remarkably high overall lipid Tisochrysis lutea strain (T+) upon gross biochemical composition, fatty acid (FA), sterol and class composition Crassostrea gigas larvae were evaluated compared with normal (T) the diatom Chaetoceros neogracile (Cg). In first experiment, influence different single diets (T, T+ Cg) bispecific diet (TCg) was studied, whereas, effects monospecific (T T+) (TCg T+Cg) in second experiment. The very rich triglycerides (TAG: 93–95% total neutral lipids),...
The PGC-1 related coactivator (PRC), which shares structural and functional features with PGC-1alpha, is believed to regulate several metabolic pathways as well mitochondrial biogenesis. Its involvement in the early programming of cell proliferation suggests existence finely regulated crosstalk between functions cycle status.PRC-regulated were explored a cell-line model derived from mitochondrial-rich tumours an essentially oxidative metabolism specifically high PRC expression. status...
Cerebral amyloid angiopathy (CAA) is an important cause of intracerebral hemorrhages in the elderly, characterized by amyloid-β (Aβ) peptide accumulating central nervous system blood vessels. Within vessel walls, Aβ-peptide deposits [composed mainly wild-type (WT) Aβ(1-40) sporadic forms] induce impaired adhesion vascular smooth muscle cells (VSMCs) to extracellular matrix (ECM) associated with their degeneration. This process often results a loss wall integrity and ultimately translates...
Anaplasma phagocytophilum is a zoonotic tick-borne intracellular alpha-proteobacterium causing fever, which leads to significant economic losses in domestic ruminants Europe. Its epidemiological cycles are complex and reservoir host species of bovine strains have not yet been identified. Given that little genetic information available on circulating within defined environment, our objective was assess the diversity A. obtained from same farms over time. Blood samplings were performed several...
The causative agent of tick-borne fever and human granulocytic anaplasmosis, Anaplasma phagocytophilum, is transmitted by Ixodes ricinus, currently considered an emerging disease throughout Europe. In this study, we established a model A. phagocytophilum sheep infection I. ricinus transmission using the European Norway variant 2 ovine strain (NV2Os) propagated in both IDE8 ISE6 tick cells. Two were inoculated with cells infected NV2Os. Both developed as determined qPCR PCR, presence 4 days...
Neuropeptides are small signaling molecules expressed in the tick central nervous system, i.e., synganglion. The neuronal-like Ixodes scapularis embryonic cell line, ISE6, is an effective tool frequently used for examining tick–pathogen interactions. We detected 37 neuropeptide transcripts I. ISE6 line using silico methods, and six of these genes were experimental validation. Among genes, tachykinin-related peptide (TRP) cells varied transcript expression depending on infection strain...
Several studies have shown that the accumulation of β-amyloid peptides in brain parenchyma or vessel wall generates an inflammatory environment. Some even suggest there is a cause-and-effect relationship between inflammation and development Alzheimer's disease and/or cerebral amyloid angiopathy (CAA). Here, we studied ability wild-type Aβ1-40 -peptide (the main peptide accumulates sporadic forms CAA) to modulate phenotypic transition vascular smooth muscle cells (VSMCs) toward...
de niveau recherche, publiés ou non, émanant des établissements d'enseignement et recherche français étrangers, laboratoires publics privés.
Microvascular endothelial cells constitute potential targets for exogenous microorganisms, in particular vector-borne pathogens. Their phenotypic and functional variations according to the organs they are coming from provide an explanation of organ selectivity expressed vivo by In order make available relevant tools vitro studies infection mechanisms, our aim was immortalize bovine organospecific but also assess their permissivity viral infection. Using transfection with SV40 large T...
The high failure rate of the in vitro aptamer selection process by SELEX (Systematic Evolution Ligands EXponential enrichment) limits production these innovative oligonucleotides and, consequently, their potential applications. generation single-stranded DNA (ssDNA) is a critical step SELEX, directly affecting enrichment and binding sequences. main goal this study was to confirm best method for generating ssDNA comparing purification ssDNA, using streptavidin-coated beads, lambda exonuclease...
A. phagocytophilum is a zoonotic and tick-borne bacterium, threatening human animal health. Many questions persist concerning the variability of strains mechanisms governing interactions with its different hosts. These gaps can be explained by difficulty to cultivate study because strict intracellular location lack specific tools, in particular monoclonal antibodies, currently unavailable. The objective our was develop DNA aptamers against phagocytophilum, or molecules expressed during...
The sarco(endo) plasmic reticulum Ca2+ ATPases (SERCA) system is a key regulator of calcium cycling and signaling in cardiac vascular myocytes composed several isoforms. We aimed to characterize 1) the expression different SERCA isoforms normal mouse cardiovascular tissues 2) modulation isoform during pathologies (heart failure and/or atherosclerosis). Five - 2a, 2b, 3a, 3b 3c were detected by RT-PCR immunoblot heart thoracic aorta. Absolute mRNA quantification (Table) confirmed that SERCA2a...