A5090360945- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Medical Image Segmentation Techniques
- Neural and Behavioral Psychology Studies
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Mental Health Research Topics
- Medical Imaging Techniques and Applications
- Neurobiology of Language and Bilingualism
- Cardiovascular Health and Disease Prevention
- Neuroinflammation and Neurodegeneration Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Image Retrieval and Classification Techniques
- Heart Rate Variability and Autonomic Control
- Optical Imaging and Spectroscopy Techniques
- Folate and B Vitamins Research
- Nutritional Studies and Diet
- Visual perception and processing mechanisms
- Amyloidosis: Diagnosis, Treatment, Outcomes
Weill Cornell Medicine
2020-2025
Cornell University
2020-2025
Columbia University
2012-2024
The Graduate Center, CUNY
2020-2024
SUNY Downstate Health Sciences University
2020-2021
Columbia University Irving Medical Center
2015-2020
Hebrew Home
2020
Nathan Kline Institute for Psychiatric Research
2019
New York State Psychiatric Institute
2019
National and Kapodistrian University of Athens
2015
To determine whether higher adherence to a Mediterranean-type diet (MeDi) is related with larger MRI-measured brain volume or cortical thickness.In this cross-sectional study, high-resolution structural MRI was collected on 674 elderly (mean age 80.1 years) adults without dementia who participated in community-based, multiethnic cohort. Dietary information via food frequency questionnaire. Total (TBV), total gray matter (TGMV), white (TWMV), mean thickness (mCT), and regional CT were derived...
Recent studies have found a deleterious effect of age on wide variety measures functional connectivity, and some hints at relationship between connectivity rest cognitive functioning. However, few combined multiple methods, or examined them over range adult ages, to try uncover which metrics networks seem be particularly sensitive age-related decline across the lifespan. The present study utilized resting state methods in sample adults from 20-80 years old gain more complete understanding...
ObjectiveTo determine efficacy of aerobic exercise for cognitive function in younger healthy adults. MethodsIn a randomized, parallel-group, observer-masked, community-based clinical trial, 132 cognitively normal individuals aged 20-67 with below median capacity were randomly assigned to one two 6-month, 4-times-weekly conditions: and stretching/ toning.Efficacy measures included capacity; several domains (executive function, episodic memory, processing speed, language, attention), everyday...
Cognitive Reserve and Brain Maintenance have traditionally been understood as complementary concepts: captures the processes underlying structural preservation of brain with age, might be assessed relative to age-matched peers. Reserve, on other hand, refers how cognitive processing can performed regardless well structure has maintained. Thus, concerns "hardware," whereas "software," that is, functioning explained by factors beyond mere structure. We used data from 368 community-dwelling...
Abstract Background We previously demonstrated that parietal lobe white matter hyperintensities (WMH) increase the risk for Alzheimer's disease (AD). Here, we examined whether individuals with apolipoprotein E gene ( APOE ε4) have increased WMH volume. Methods Participants were from Washington Heights‐Inwood Columbia Aging Project (WHICAP; n = 694, 47 dementia) in northern Manhattan and Etude Santé Psychologique Prévalence Risques et Traitement study (ESPRIT; 539, 8 Montpellier. The...
Introduction After infection, herpes simplex virus-1 (HSV1) becomes latent in the trigeminal ganglion and can enter brain via retrograde axonal transport. Recurrent reactivation of HSV1 may lead to neurodegeneration Alzheimer’s disease (AD) pathology. (oral herpes) HSV2 (genital trigger amyloid beta-protein (Aβ) aggregation DNA is common plaques. Anti-HSV drugs reduce Aβ phosphorylated tau accumulation cell-culture models. Cognitive impairment greater patients with HSV seropositive,...
While amyloid-beta and tau are known to be the key neuropathological hallmarks of Alzheimers disease (AD), imaging postmortem studies highlight significant variability in severity progression even subjects with similar burdens amyloid-beta; accumulation. This uncertainty trajectory results substantial challenges for patients their families understanding prognosis, as well research community heterogeneity rate Aβ accumulation, cognitive decline, likelihood progressing dementia. In this study,...
<h3>ABSTRACT</h3> <h3>BACKGROUND AND PURPOSE:</h3> Accurate identification of cerebral beta-amyloid (Aβ) accumulation is crucial for diagnosing Alzheimer's disease (AD) and determining eligibility anti-Aβ therapies. The Centiloid (CL) scale has emerged as a standardized method to harmonize Aβ positron emission tomography (PET) quantification across different tracers sites. We aimed evaluate the concordance between CL visual interpretation in cohort cognitively impaired (CI) unimpaired (CU)...
Evidence suggests that individual variability in lifetime exposures influences how cognitive performance changes with advancing age. Brain maintenance and reserve are theories meant to account for preserved despite These differ their causal mechanisms. predicts more advantageous will reduce age-related neural differences. Cognitive not directly these differences but minimize impact on performance. The present work used moderated-mediation modeling investigate the contributions of mechanisms...
Abstract Studies of cognitive function that compare the blood oxygenation level dependent (BOLD) signal across age groups often require assumption neurovascular coupling does not change with age. Tests this have produced mixed results regarding strength and its relative time course. Using deconvolution, we found a significant effect on course hemodynamic impulse response or slope BOLD versus stimulus duration relationship. These suggest in studies healthy aging, group differences activation...
The role of the hippocampus in memory is dependent on its interaction with distributed brain areas. Anterior and posterior have different roles processing, are impacted differently by aging terms structural decline, however, functional connectivity these hippocampal regions not well understood. Young (age 17–30) 60–69) cognitively normal subjects underwent resting-state MRI revealing a shift from anterior dominant younger age group to subjects. We identified subset neocortical that connected...
Due to the nature of fMRI acquisition protocols, slices cannot be acquired simultaneously, and as a result, are temporally misaligned from each other. To correct this misalignment, preprocessing pipelines often incorporate slice timing correction (STC). However, evaluating benefits STC is challenging because it 1) dependent on parameters, 2) interacts with head movement in non-linear fashion, 3) significantly changes other steps, experimental design, parameters. Presently, interaction...
Research on the cognitive neuroscience of aging has identified myriad neurocognitive processes that are affected by process, with a focus identifying neural correlates function in aging. This study aimed to test whether internetwork connectivity among six networks is sensitive age-related changes efficiency and functioning. A factor analytic approach was used model network interactions during 11 tasks grouped into four primary domains: vocabulary, perceptual speed, fluid reasoning, episodic...
Early-life education (years of schooling) has been investigated in regards to cognition, health outcomes and mortality. It shown confer cognitive reserve that might lessen the impact brain pathology its on motor functioning a variety neurodegenerative diseases and, for instance, influence electrical activity [Begum, T., Reza, F., Ahmed, I., & Abdullah, J. M. (2014). Influence level design-induced N170 P300 components event related potentials human brain. J Integr Neurosci, 13(1), 71–88....
Abstract Background Amyloid deposition is a primary predictor of Alzheimer’s disease (AD) and related neurodegenerative disorders. Retinal changes involving the structure function ganglion cell layer are increasingly documented in both established prodromal AD. Visual event-related potentials (vERP) sensitive to dysfunction magno- parvocellular visual systems, which originate within retinal layer. The present study evaluates vERP as amyloid aging, mild cognitive impairment (MCI). Methods...