A5048546365- Nausea and vomiting management
- Anesthesia and Pain Management
- Gastrointestinal motility and disorders
- Neuropeptides and Animal Physiology
- Regulation of Appetite and Obesity
- Pharmacological Effects and Toxicity Studies
- Ion Channels and Receptors
- Pain Mechanisms and Treatments
- Sirtuins and Resveratrol in Medicine
- Acupuncture Treatment Research Studies
- Healthcare and Venom Research
- Complementary and Alternative Medicine Studies
- Neuroscience and Neuropharmacology Research
- Cancer Treatment and Pharmacology
- Receptor Mechanisms and Signaling
- Alzheimer's disease research and treatments
- Cardiac electrophysiology and arrhythmias
- Infant Health and Development
- Pituitary Gland Disorders and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Neuroendocrine regulation and behavior
- Chemotherapy-induced organ toxicity mitigation
- Neuroinflammation and Neurodegeneration Mechanisms
- Pediatric Pain Management Techniques
- Anesthesia and Sedative Agents
Chinese University of Hong Kong
2016-2025
Guy's and St Thomas' NHS Foundation Trust
2013-2022
Faculty (United Kingdom)
2015
Shatin Hospital
2015
King's College London
2013
Kings Health Partners
2013
Hong Kong Jockey Club
2010
Hong Kong University of Science and Technology
2009
University of Hong Kong
2005-2009
University of Applied Sciences Kaiserslautern
2009
Doxorubicin induced functional deteriorations and elevations of USP7-related apoptotic/catabolic signalling in the senescent heart Resveratrol protects against doxorubicin-induced alterations through restoration SIRT1 deacetylase activityA compromised cardiac function is often seen elderly cancer patients receiving doxorubicin therapy. The present study tested hypothesis that acute intervention with resveratrol, a natural anti-oxidant found grapes red wine, reduces cardiotoxicity sirtuin 1...
Alzheimer's disease (AD) patients and transgenic mice have beta-amyloid (Aβ) aggregation in the gastrointestinal (GI) tract. It is possible that Aβ from periphery contributes to load of brain, as has prion-like properties. The present investigations demonstrate injected into GI tract ICR internalised enteric cholinergic neurons; at 1 month, administration body stomach proximal colon was observed partly redistribute fundus jejunum; year, vagal cerebral β-amyloidosis present, exhibited...
An unusual polyprenylated acylphloroglucinol derivative unsubstituted at C-2 and C-6, garcicowin A (1), together with three other new (garcicowins B−D, 2−4) nine known analogues, was isolated characterized from the twigs of Garcinia cowa. The structures 1−4 were elucidated by interpretation their spectroscopic data. compounds evaluated for cytotoxicity against two cancer cell lines (HT-29 HCT116) normal colon cells (CCD-18Co), results demonstrated selective toxicity toward cells.
Elevations of cardiomyocyte apoptosis and fibrotic deposition are major characteristics the ageing heart. Resveratrol, a polyphenol in grapes red wine, is known to improve insulin resistance increase mitochondrial biogenesis through SIRT1-PGC-1α signalling axis. Recent studies attempted relate SIRT1 activation by resveratrol regulation various disease models cardiac muscle. In present study, we tested hypothesis that long-term (8-month) treatment would activate function senescent mice...
Abstract Blood pressure is maintained within a normal physiological range by sophisticated regulatory mechanism. Baroreceptors serve as frontline sensor to detect the change in blood pressure. Nerve signals are then sent cardiovascular control centre brain order stimulate baroreflex responses. Here, we identify TRPC5 channels mechanical aortic baroreceptors. In Trpc5 knockout mice, pressure-induced action potential firings afferent nerve and baroreflex-mediated heart rate reduction...
It has previously been demonstrated that ischemic stroke activates autophagy pathways; however, the mechanism remains unclear. The aim of this study is to further investigate role plays in cerebral ischemia. 2, 4‐diamino‐6‐hydroxy‐pyrimidine (DAHP), for its nitric oxide synthase (NOS) inhibiting neuroprotective effect, and triptolide (TP), anti‐inflammatory property, were selected administer pre middle artery occlusion (MCAO). drugs administered 12 hours prior MCAO. Both magnetic resonance...
Abstract Quantifying emesis in Suncus murinus ( S. ) has traditionally relied on direct observation or reviewing recorded behaviour, which are laborious, time-consuming processes that susceptible to operator error. With rapid advancements deep learning, automated animal behaviour quantification tools with high accuracy have emerged. In this study, we pioneere the use of both three-dimensional convolutional neural networks and self-attention mechanisms develop Automatic Emesis Detection (AED)...
1. The anti-emetic effects of the NK1 tachykinin receptor antagonist, CP 99,994 (10 mg kg-1) were investigated in ferret using a cisplatin-induced acute (day 1) and delayed 2 3) retching vomiting model. 2. With single cisplatin emetogenic challenge, i.p. administration given as injection immediately following first emetic episode, promptly abolished for 4 h period. was efficacious ondansetron (1.0 kg-1). general toxicity 10 kg-1 precluded its use studies emesis. 3. (5 either or episode...
Alzheimer's disease (AD) is a common form of dementia which characterized by the deposition amyloids in affected neurons and cholinergic neurotransmission deficit brain. The current therapeutic intervention for AD primarily based on inhibition brain acetylcholinesterase (AChE) to restore acetylcholine level. Cryptotanshinone (CT) diterpene extracted from root Salvia miltiorrhiza, herb that commonly prescribed Chinese medicine treat cardiovascular disease. In present study, we demonstrated CT...
Ketamine is a well-known anesthetic agent and drug of abuse. Despite its widespread use abuse, little known about long-term effects on the central nervous system. The present study was designed to evaluate effect (1- 3-month) ketamine administration learning memory associated gene expression levels in brain. Morris water maze used assess spatial changes were assayed using Affymetrix Genechips; focus GABAA receptors that mediate tonic inhibition brain, confirmed by quantitative real-time PCR...