A5050341411- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Autophagy in Disease and Therapy
- Chemotherapy-induced cardiotoxicity and mitigation
- Diet and metabolism studies
- Sirtuins and Resveratrol in Medicine
- Cardiovascular Disease and Adiposity
- Cardiovascular and exercise physiology
- Sports injuries and prevention
- Diabetic Foot Ulcer Assessment and Management
- Children's Physical and Motor Development
- Cancer Treatment and Pharmacology
- Calcium signaling and nucleotide metabolism
- Dietary Effects on Health
- Metabolism, Diabetes, and Cancer
- Telomeres, Telomerase, and Senescence
- Peroxisome Proliferator-Activated Receptors
- Hematological disorders and diagnostics
- Mentoring and Academic Development
- Growth Hormone and Insulin-like Growth Factors
- Parkinson's Disease Mechanisms and Treatments
- Physical Activity and Health
- Cardiac Fibrosis and Remodeling
- Extracellular vesicles in disease
Hong Kong Baptist University
2023-2025
Concordia University
2018-2025
University of Toronto
2024
University of North Carolina at Chapel Hill
2018-2023
Centre intégré universitaire de santé et de services sociaux du Nord-de-l’Île-de-Montréal
2020-2023
Hôpital du Sacré-Cœur de Montréal
2020-2023
The University of Texas MD Anderson Cancer Center
2019
Hong Kong Polytechnic University
2014-2018
Chinese University of Hong Kong
2010
Doxorubicin induced functional deteriorations and elevations of USP7-related apoptotic/catabolic signalling in the senescent heart Resveratrol protects against doxorubicin-induced alterations through restoration SIRT1 deacetylase activityA compromised cardiac function is often seen elderly cancer patients receiving doxorubicin therapy. The present study tested hypothesis that acute intervention with resveratrol, a natural anti-oxidant found grapes red wine, reduces cardiotoxicity sirtuin 1...
<h3>Importance</h3> Previous studies that have shown tai chi to improve sleep were mainly based on subjective assessments, which might produced results confounded by self-reporting bias. <h3>Objective</h3> To compare the effectiveness of for improving in older adults with insomnia conventional exercise and a passive control group using actigraphy-based objective measurements. <h3>Design, Setting, Participants</h3> This randomized, 3-arm, parallel group, assessor-masked clinical trial was...
Osteolytic lesions in multiple myeloma are caused by osteoclast-mediated bone resorption and reduced formation. A unique feature of is a failure healing after successful treatment. We observed adipocytes on trabecular near the resorbed area successfully treated patients. Normal marrow adipocytes, when cocultured with cells, were reprogrammed produced adipokines that activate osteoclastogenesis suppress osteoblastogenesis. These have expression peroxisome proliferator-activated receptor γ...
Metabolic syndrome (MetS) or prediabetes is a complex disorder that defined by clustering of cardiometabolic risk factors, including obesity, hypertriglyceridemia, reduced high-density lipoprotein (HDL) cholesterol, hypertension, and insulin resistance. Among central obesity plays key role in the development MetS through alterations secretion adipokines interacts with other factors to unfavorably influence overall risk. Obesity has grasped epidemic proportions Asia, which highest number...
Acute exercise is known to activate autophagy in skeletal muscle. However, little about how basal muscle adapts chronic exercise. In the current study we aim to, firstly, examine whether long-term habitual alters autophagic signalling plantaris and, secondly, association between and fibre-type shifting.Adult female Sprague-Dawley rats aged 2 months were randomly assigned control groups. Animals group kept cages equipped with free access running wheels perform for 5 months. caged absence of...
Study of the exacerbating effects chemotherapeutics, such as doxorubicin, on impairment insulin metabolic signaling in aged skeletal muscle is very limited. Here, we tested hypothesis that activation sirtuin 1 deacetylase activity by resveratrol would prevent disruption and augmentation catabolic markers induced doxorubicin muscle. Two- 10-month-old senescence-accelerated mice (prone 8) were randomized to receive saline, resveratrol, or a combination sirtinol EX527. Doxorubicin reduced...
Anti-cancer agent doxorubicin (DOX) has been demonstrated to worsen insulin signaling, engender muscle atrophy, trigger pro-inflammation, and induce a shift anaerobic glycolytic metabolism in skeletal muscle. The myotoxicity of DOX diabetic remains largely unclear. This study examined the effects on pro-/anti-inflammatory microenvironment, glycolysis metabolic regulation db/db db/+ non-diabetic mice. Non-diabetic mice were randomly assigned following groups: db/+CON, db/+DOX, db/dbCON,...
Abstract Objective The aim of this study was to determine the effect age obesity onset on senescence‐related markers in abdominal (AB) and femoral (FEM) subcutaneous adipose tissue (SAT) before after moderate (~10%) weight loss. Methods AB FEM SAT were collected from human females with childhood‐onset (CO) or adult‐onset (AO) diet‐ exercise‐induced Immunofluorescence analysis γH2AX/RAD51 (DNA damage/repair markers) p53/p21 (senescence conducted cultured preadipocytes, senescence‐associated...
Metabolic syndrome (MetS) contains a cluster of cardiovascular risk factors. People with MetS are more susceptible to disease, diabetes mellitus, and cancer. Endothelin-1 (ET-1) matrix metallopeptidase-9 (MMP-9) have been implicated in the development diseases, mellitus cancers. This cross-sectional study aimed examine association ET-1 MMP-9 middle-aged older Hong Kong Chinese adults.149 adults aged 50 92 (n = 75 for non-MetS group n 74 group) were examined. All subjects screened according...
Introduction: Metabolic syndrome (MetS) is a multiplex cardiometabolic manifestation associated with type 2 diabetes mellitus and cardiovascular diseases. Yoga training has been shown to alleviate MetS. Recently, circulatory ghrelin profile was demonstrated be This study examined the effects of 1 year yoga on β-cell function insulin resistance, involvement metabolic peptides, including unacylated (UnAG), acylated (AG), obestatin, growth hormone (GH), insulin, in beneficial centrally obese...
Cardiomyopathy is a clinical problem that occurs in the hearts of type 2 diabetic patients as well cancer undergoing doxorubicin chemotherapy. The number increasing but surprisingly cardiac damaging effects doxorubicin, commonly used chemotherapeutic drug, on have not been well-examined. As signaling mechanisms doxorubicin-induced cardiomyopathy heart are largely unknown, this study examined molecular pathways responsible for cardiotoxicity hearts. Male 14- to 18-week-old db/db mice were...
Unacylated ghrelin, the predominant form of circulating protects myotubes from cell death, which is a known attribute pressure ulcers. In this study, we investigated whether unacylated ghrelin skeletal muscle pressure-induced deep tissue injury by abolishing necroptosis and apoptosis signaling these effects were mediated SIRT1 pathway. Fifteen adult Sprague Dawley rats assigned to receive saline or with without EX527 (a inhibitor). Animals underwent two 6-h compression cycles 100 mmHg static...
This study aims to examine the comparative effects of 75 min volume-matched once-weekly and thrice-weekly high-intensity interval training (HIIT) on body adiposity in adults with central obesity. assessor-blinded, three-arm, randomized controlled trial will recruit 315 physically inactive obesity (aged ≥18 years, mass index ≥23, waist circumference ≥90 cm for men ≥80 women). Participants be randomly allocated HIIT, HIIT or usual care control group. groups receive weekly exercise sessions 16...
Abstract Objective We aimed to examine the effect of age obesity onset, sex, and their interaction on abdominal femoral subcutaneous adipose tissue (SAT) morphology (degree adipocyte hyperplasia or hypertrophy). Methods In this cross‐sectional study, we isolated adipocytes via collagenase digestion from SAT biopsies taken male female adults with childhood‐onset (CO; n = 8 males, 16 females) adult‐onset (AO; 13 females). Regional body composition was measured dual‐energy x‐ray absorptiometry...
Autophagy has been shown to be responsive physical exercise. However, the effects of prolonged habitual exercise on autophagy in cardiac muscle remain unknown. The present study aimed examine whether long-term alters basal autophagic signalling muscle. Female Sprague-Dawley rats aged 2 months were randomly assigned control and groups. Animals group kept cages with free access wheels perform for 5 months. placed without wheels. Ventricular tissues harvested analysis after Phosphorylation...