A5035781981- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Physical Activity and Health
- Sirtuins and Resveratrol in Medicine
- Sleep and related disorders
- Stroke Rehabilitation and Recovery
- Cardiovascular Disease and Adiposity
- Regulation of Appetite and Obesity
- Sleep and Wakefulness Research
- Dietary Effects on Health
- Diabetic Foot Ulcer Assessment and Management
- Cardiovascular and exercise physiology
- Calcium signaling and nucleotide metabolism
- Heart Rate Variability and Autonomic Control
- Autophagy in Disease and Therapy
- Obesity, Physical Activity, Diet
- Balance, Gait, and Falls Prevention
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chemotherapy-induced cardiotoxicity and mitigation
- Circadian rhythm and melatonin
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Cardiovascular Function and Risk Factors
- Cardiac Health and Mental Health
- Nutrition and Health in Aging
University of Hong Kong
2017-2024
UNSW Sydney
2021
Hong Kong Polytechnic University
2012-2015
<h3>Importance</h3> Previous studies that have shown tai chi to improve sleep were mainly based on subjective assessments, which might produced results confounded by self-reporting bias. <h3>Objective</h3> To compare the effectiveness of for improving in older adults with insomnia conventional exercise and a passive control group using actigraphy-based objective measurements. <h3>Design, Setting, Participants</h3> This randomized, 3-arm, parallel group, assessor-masked clinical trial was...
Background: Central obesity is a major manifestation of metabolic syndrome, which common health problem in middle-aged and older adults. Objective: To examine the therapeutic efficacy tai chi for management central obesity. Design: Randomized, controlled, assessor-blinded trial. (ClinicalTrials.gov: NCT03107741) Setting: A single research site Hong Kong between 27 February 2016 28 2019. Participants: Adults aged 50 years or with Intervention: 543 participants were randomly assigned 1:1:1...
Elevations of cardiomyocyte apoptosis and fibrotic deposition are major characteristics the ageing heart. Resveratrol, a polyphenol in grapes red wine, is known to improve insulin resistance increase mitochondrial biogenesis through SIRT1-PGC-1α signalling axis. Recent studies attempted relate SIRT1 activation by resveratrol regulation various disease models cardiac muscle. In present study, we tested hypothesis that long-term (8-month) treatment would activate function senescent mice...
Metabolic syndrome (MetS) is a clustering of cardiovascular risk factors, which associated with diabetes mellitus and disease. Lifestyle interventions applied to people MetS has considerable beneficial effects on disease preventive outcomes. This study aimed examine the 1-year yoga exercise factors including central obesity, hypertension, dyslipidemia hyperglycemia in middle-aged older Hong Kong Chinese adults MetS.Adults diagnosed using National Cholesterol Education Program criteria (n =...
Doxorubicin, a potent chemotherapeutic drug, has been demonstrated previously as an inducer of apoptosis in muscle cells. Extensive induction may cause excessive loss cells and subsequent functional decline skeletal muscle. This study examined the effects acylated ghrelin, potential agent for treating cancer cachexia, on inhibiting apoptotic signalling doxorubicin-treated Unacylated form ghrelin that does not bind to GHSR-1a, is also employed this examine GHSR-1a dependency ghrelin.Adult...
ABSTRACT Background The relationship between the frequency of high-intensity interval training (HIIT) and resultant adaptations is largely unclear. Purpose This study compared effects different frequencies HIIT with those moderate-intensity continuous (MICT) on body composition in overweight or obese adults. Methods Fifty-six (body mass index = 26.4 ± 2.9) men 18 30 yr old (age 22.8 3.1 yr) were randomly assigned to following groups: no-intervention control (CON; n 14), MICT performed thrice...
Abstract Studies have shown that Tai Chi and conventional exercise can modify the brain through distinct mechanisms, resulting in different adaptations. Therefore, it is conceivable to speculate these two modalities may effects on improving cognitive function. This study was a parallel group, assessor-blinded, pilot randomized controlled trial comparing of function older persons with mild impairment (MCI). A total 34 adults aged ≥ 50 years MCI were (1:1:1) group (TC, n = 10, 3 sessions...
Metabolic syndrome (MetS) or prediabetes is a complex disorder that defined by clustering of cardiometabolic risk factors, including obesity, hypertriglyceridemia, reduced high-density lipoprotein (HDL) cholesterol, hypertension, and insulin resistance. Among central obesity plays key role in the development MetS through alterations secretion adipokines interacts with other factors to unfavorably influence overall risk. Obesity has grasped epidemic proportions Asia, which highest number...
ABSTRACT The optimal intensity of physical activity for alleviating depression in middle‐aged and older adults remains unclear. World Health Organization (WHO) guidelines recommend to accumulate at least 150–300 minutes moderate or 75–150 vigorous aerobic‐type weekly an equivalent combination both health benefits including reduced risk depression. This parallel, assessor‐blinded, pilot randomized controlled trial preliminarily compared the effectiveness minimal volume different intensities...
Background: The World Health Organization physical activity guidelines recommend adults and older to accumulate at least 150-300 min of moderate or 75-150 vigorous aerobic-type weekly for health benefits including improvements cognitive performance. However, the optimal exercise intensity frequency maximizing remain unclear. Purpose: We conducted a parallel, assessor-blinded, pilot randomized controlled trial evaluate effectiveness different intensities frequencies WHO-recommended minimal...
Acute exercise is known to activate autophagy in skeletal muscle. However, little about how basal muscle adapts chronic exercise. In the current study we aim to, firstly, examine whether long-term habitual alters autophagic signalling plantaris and, secondly, association between and fibre-type shifting.Adult female Sprague-Dawley rats aged 2 months were randomly assigned control groups. Animals group kept cages equipped with free access running wheels perform for 5 months. caged absence of...
Study of the exacerbating effects chemotherapeutics, such as doxorubicin, on impairment insulin metabolic signaling in aged skeletal muscle is very limited. Here, we tested hypothesis that activation sirtuin 1 deacetylase activity by resveratrol would prevent disruption and augmentation catabolic markers induced doxorubicin muscle. Two- 10-month-old senescence-accelerated mice (prone 8) were randomized to receive saline, resveratrol, or a combination sirtinol EX527. Doxorubicin reduced...
Metabolic syndrome (MetS) is associated with diabetes mellitus and cardiovascular diseases. Our previous study indicated that people MetS showed a decrease in waist circumference decreasing trend blood pressure after 1-year yoga. This investigated the effect of yoga on high-normal by exploring modulations proinflammatory adipokines (leptin, chemerin, visfatin, plasminogen activator inhibitor-1 or PAI-1) an anti-inflammatory adipokine (adiponectin). A total 97 Hong Kong Chinese individuals...
Metabolic syndrome (MetS) contains a cluster of cardiovascular risk factors. People with MetS are more susceptible to disease, diabetes mellitus, and cancer. Endothelin-1 (ET-1) matrix metallopeptidase-9 (MMP-9) have been implicated in the development diseases, mellitus cancers. This cross-sectional study aimed examine association ET-1 MMP-9 middle-aged older Hong Kong Chinese adults.149 adults aged 50 92 (n = 75 for non-MetS group n 74 group) were examined. All subjects screened according...
Introduction: Metabolic syndrome (MetS) is a multiplex cardiometabolic manifestation associated with type 2 diabetes mellitus and cardiovascular diseases. Yoga training has been shown to alleviate MetS. Recently, circulatory ghrelin profile was demonstrated be This study examined the effects of 1 year yoga on β-cell function insulin resistance, involvement metabolic peptides, including unacylated (UnAG), acylated (AG), obestatin, growth hormone (GH), insulin, in beneficial centrally obese...
Insomnia and depression are prevalent mental disorders that often comorbid among older adults. Lifestyle intervention strategies incorporating Tai Chi or conventional exercise have been shown to alleviate symptoms of insomnia depression. However, the comparative efficacy these modalities in individuals with both has yet be determined. Therefore, aim this study is examine for reducing depressive adults chronic symptoms, when compared a health education control. This prospective,...
This study aims to examine the effects of one-year, once-weekly high-intensity interval training (HIIT) on body adiposity and liver fat in adults with central obesity.One-hundred twenty aged 18-60 years obesity (body mass index ≥25, waist circumference ≥90 cm for men ≥80 women). is an assessor-blinded randomized controlled trial. Participants will be randomly assigned HIIT group or usual care control group. Each session consist 4 × 4-min bouts at 85%-95% maximal heart rate, interspersed...
Unacylated ghrelin, the predominant form of circulating protects myotubes from cell death, which is a known attribute pressure ulcers. In this study, we investigated whether unacylated ghrelin skeletal muscle pressure-induced deep tissue injury by abolishing necroptosis and apoptosis signaling these effects were mediated SIRT1 pathway. Fifteen adult Sprague Dawley rats assigned to receive saline or with without EX527 (a inhibitor). Animals underwent two 6-h compression cycles 100 mmHg static...
This study aims to examine the comparative effects of 75 min volume-matched once-weekly and thrice-weekly high-intensity interval training (HIIT) on body adiposity in adults with central obesity. assessor-blinded, three-arm, randomized controlled trial will recruit 315 physically inactive obesity (aged ≥18 years, mass index ≥23, waist circumference ≥90 cm for men ≥80 women). Participants be randomly allocated HIIT, HIIT or usual care control group. groups receive weekly exercise sessions 16...
Pressure-induced injury (PI), such as a pressure ulcer, in patients with limited mobility is healthcare issue worldwide. PI an to skin and its underlying tissue skeletal muscle. Muscle compression, composed of mechanical deformation muscle external load, leads localized ischemia subsequent unloading reperfusion and, hence, ulcer bed-bound patients. Although the gross factors involved have been identified, little known about exact disease mechanism or links apoptosis, autophagy inflammation....