A5100755442- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Catalytic Alkyne Reactions
- Cyclopropane Reaction Mechanisms
- Oxidative Organic Chemistry Reactions
- Synthesis and Catalytic Reactions
- Acute Ischemic Stroke Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sulfur-Based Synthesis Techniques
- Neurogenetic and Muscular Disorders Research
- Chemical Synthesis and Reactions
- Chemical Synthesis and Analysis
- Asymmetric Hydrogenation and Catalysis
- Cancer Genomics and Diagnostics
- Winter Sports Injuries and Performance
- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- Organic and Inorganic Chemical Reactions
- Bone fractures and treatments
- Immune Response and Inflammation
- Anesthesia and Neurotoxicity Research
- Synthesis and Characterization of Heterocyclic Compounds
- Gastric Cancer Management and Outcomes
- Immune Cell Function and Interaction
- Head and Neck Cancer Studies
Fujian Medical University
2011-2024
Sun Yat-sen University Cancer Center
2007-2024
Sun Yat-sen University
2007-2024
First Affiliated Hospital of Fujian Medical University
2011-2024
State Key Laboratory of Oncology in South China
2013-2024
Binzhou University
2024
Binzhou Medical University
2024
Fudan University
2024
Xiangnan University
2023
Bridge University
2023
Keeping options open: The new and mild title reaction involving indoles selectively furnishes 1 2 with the aid of tert-butyl hydroperoxide (TBHP). method represents first example a copper-catalyzed α arylation α-amino carbonyl substrates leading to α-aryl α-imino α-oxo compounds using CH oxidation strategy.
Little is known about the role of association between ABO blood type and risk pancreatic cancer develops through effects on hepatitis B viral (HBV) infection. Our study aimed to determine whether joint HBV infection could increase for cancer. A total 645 patients with adenocarcinoma 711 age- sex-matched individuals who had nonmalignant diseases treated at Sun Yat-sen University Cancer Center in China were retrospectively analyzed. Blood samples tested surface antigen (HBsAg), antibody...
Osteolytic lesions in multiple myeloma are caused by osteoclast-mediated bone resorption and reduced formation. A unique feature of is a failure healing after successful treatment. We observed adipocytes on trabecular near the resorbed area successfully treated patients. Normal marrow adipocytes, when cocultured with cells, were reprogrammed produced adipokines that activate osteoclastogenesis suppress osteoblastogenesis. These have expression peroxisome proliferator-activated receptor γ...
The novel CuCl2-catalyzed title reaction of enynes has been developed for synthesizing substituted naphthoquinones (see scheme; DMA=dimethylacetamide). method represents the first example a copper-catalyzed enyne oxidative cyclization constructing 1,4-naphthoquinones by incorporation two oxygen atoms into organic framework from molecular and water. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or...
Background/Aims: A combination sevoflurane postconditioning (SPC) and remote ischemic preconditioning (RIPC) is proved effective in an ex vivo rat heart perfusion model. However, the combined effect of those two interventions not tested myocardial ischemia/reperfusion (I/R) model, underlying mechanisms remain to be elucidated. This study aimed investigate using a I/R model illuminate related mechanisms. Methods: Forty male Sprague-Dawley rats were randomly divided into following 5 groups: i)...
Objective Oculopharyngodistal myopathy (OPDM) is an adult‐onset neuromuscular disease characterized by progressive ptosis, dysarthria, ophthalmoplegia, and distal muscle weakness. Recent studies revealed that GGC repeat expansions in 5′‐UTR of LRP12 , GIPC1 NOTCH2NLC are associated with OPDM. Despite these advances, approximately 30% OPDM patients remain genetically undiagnosed. Herein, we aim to investigate the genetic basis for undiagnosed two unrelated Chinese Han families. Methods...
Several large studies have reported an extremely low incidence of MET gene amplification (GA) in patients with radically resected gastric cancer. This study was conducted to evaluate the prevalence and prognostic role recurrent=metastatic cancer who received chemotherapy.MET GA protein expression samples were evaluated by fluorescence situ hybridization immunohistochemistry (IHC), respectively.This retrospective included 232 strong expression(IHC31) observed 8.3% (19 230 samples) 9.6% (22...
The objective of this study was to examine whether the regional methylation levels at most distal D4Z4 repeat units (RU) in 4qA-permissive haplotype were associated with disease severity and progression facioscapulohumeral muscular dystrophy type 1 (FSHD1).This 21-year, retrospective, observational cohort conducted Fujian Neuromedical Center (FNMC) China. Methylation RU, including 10 CpGs, assessed all participants by bisulfite sequencing. Patients FSHD1 stratified into 4 groups based on...
BRD7 is a member of bromodomain-containing protein and was found to be cofactor P53. Down-regulation has been shown in nasopharyngeal carcinoma cell lines tissues. However, the clinical role colorectal cancer remains unknown.Real-time PCR, Western blotting analysis immunohistochemistry were employed examine expression CRC lines/tissues compared with normal epithelia cells/adjacent non-tumorous In addition, statistical analyses applied evaluate diagnostic value associations parameters patient...
Imino oder Oxo: Die Titelreaktion unter Verwendung von tert-Butylhydroperoxid (TBHP) überführt Indole selektiv und milden Bedingungen in die Produkte 1 2. Es handelt sich um erste kupferkatalysierte α-Arylierung α-Aminocarbonyl-Substraten zu α-Aryl-α-imino- α-Aryl-α-oxocarbonyl-Verbindungen über eine C-H-Oxidation. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made available...
Abstract Background Oxaliplatin, irinotecan, 5‐fluorouracil, and l ‐leucovorin (FOLFIRINOX) has become one of the first‐line treatment options for advanced pancreatic cancer (PC). However, relatively high rate grade 3 or 4 adverse events associated with standard dosage FOLFIRINOX limits its widespread use in clinical practice. In this study, we were to evaluate efficacy safety a modified regimen as chemotherapy Chinese patients metastatic PC. Methods Patients histologically confirmed primary...
Mollisols are globally distributed in grain-producing regions, and soil organic carbon (SOC) dynamics mollisol regions closely related to food security. Regional climate, land use cover, field management practice have massively changed since the 1980s region Northeast China, however, of topsoil profile SOC stocks their distribution not updated. To explore horizontal vertical distributions 1980s-2010s, we took China as an example location conduct profile-scale surveys. The situ surveys...
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, pathologically characterized by TDP-43 aggregates. Recent evidence has been indicated that phosphorylated (pTDP-43) present not only in motor neurons but also muscle tissues. However, it unclear whether testing pTDP-43 aggregation tissue would assist the diagnosis of ALS. We propose three key questions: (i) Is detectable routine biopsied muscles? (ii) Can detection discriminate between ALS and non-ALS patients?...
Substituierte Naphthochinone sind die Produkte der CuCl2-katalysierten Titelreaktion (siehe Schema; DMA=Dimethylacetamid). Bei dieser kupferkatalysierten oxidativen Enincyclisierung werden erstmalig 1,4-Naphthochinone unter Einführung zweier Sauerstoffatome aus molekularem Sauerstoff und Wasser in ein organisches Molekülgerüst aufgebaut. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset....
Abstract A series of ferrocenyl palladacycles with polydentate ligands were conveniently prepared by the Suzuki coupling reactions a halide‐containing palladacycle [PdCl({(η 5 ‐C H )}Fe{(η 3 )N 2 C 4 Cl})(PPh )] ( 1 ) andarylboronic acids without additional palladium catalysis. In absence base, amination also occurred in high yield. This new protocol was successfully applied to analogous )NC Br})(PPh 15 and Buchwald–Hartwig complex Br})(DCPAB)] 32 ), where DCPAB =...
Background and Purpose: Prehospital delay is the major factor limiting intravenous thrombolysis mechanical thrombectomy in acute ischemic stroke (AIS). This study aimed to: (1) identify factors related to prehospital (2) determine impact of recognition behavior family members on patient delay. Methods: A cross-sectional, multicenter was conducted at six teaching hospitals China between December 1, 2018 November 30, 2019. Patients who experienced AIS within 7 days onset were interviewed....
659 Background: Advanced pancreatic adenocarcinoma (PDAC) had poor survival and limited therapeutic options. Surufatinib is a potent, small-molecule tyrosine kinase inhibitor (TKI), selectively targeting VEGF receptors (VEGFR) 1, 2, 3, FGFR CSF-1R. Recent studies showed that small molecule anti-vascular combined with PD-1 exhibited encouraging efficacy in PDAC. This study to assess the safety of surufatinib plus sintilimab (an anti-PD-1 antibody),nab-paclitaxel gemcitabine(AG) as first-line...