A5080271134- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Zebrafish Biomedical Research Applications
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Adipose Tissue and Metabolism
- Genetics and Neurodevelopmental Disorders
- Diet and metabolism studies
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Biochemical effects in animals
- Neurogenesis and neuroplasticity mechanisms
- Alcoholism and Thiamine Deficiency
- Medicinal Plants and Bioactive Compounds
- Immune Response and Inflammation
- Attention Deficit Hyperactivity Disorder
- Amyotrophic Lateral Sclerosis Research
- Immune cells in cancer
- Treatment of Major Depression
- Glycosylation and Glycoproteins Research
Maastricht University
2016-2025
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences
2016-2025
Universitätsklinikum Würzburg
2017-2025
Peoples' Friendship University of Russia
2025
University of Würzburg
2017-2025
University of Oxford
2014-2024
Sechenov University
1995-2023
Institute of Molecular Medicine
2022
St Petersburg University
2021
European Graduate School of Neuroscience
2016-2017
The immediate early gene c-fos is part of the activator protein-1 transcription factor and has been postulated to participate in molecular mechanisms learning memory. To test this hypothesis vivo, we generated mice with a nervous system-specific knock-out using Cre-loxP system. Adult lacking c-Fos CNS (c-fosDeltaCNS) showed normal general emotional behavior but were specifically impaired hippocampus-dependent spatial associative tasks. These deficits correlated reduction long-term...
Chronic stress is broadly used to model anxiety and depression. However, in chronic models, anxiety- depression-like behaviors might be masked by unspecific effects of stress. We tested whether mice can induce changes locomotion, these interfere with the measurement forced-swimming behaviors. Also, we studied latter relation duration stress, lighting conditions during testing, after injection diazepam. employed a 4-week paradigm, adopted from stress-induced anhedonia 1-week subchronic both...
The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated human rodent brains, identified ZDHHC21 as a palmitoyl acyltransferase, whose depletion reduced palmitoylation consequently signaling functions of 5-HT1AR. Two models for depression-like behavior show brain expression attenuated palmitoylation. Moreover, selective knock-down the murine forebrain induced behavior. We also...
Abstract Cadherin-13 (CDH13), a unique glycosylphosphatidylinositol-anchored member of the cadherin family cell adhesion molecules, has been identified as risk gene for attention-deficit/hyperactivity disorder (ADHD) and various comorbid neurodevelopmental psychiatric conditions, including depression, substance abuse, autism spectrum violent behavior, while mechanism whereby CDH13 dysfunction influences pathogenesis neuropsychiatric disorders remains elusive. Here we explored potential role...
Aggression, hyperactivity, impulsivity, helplessness and anhedonia are all signs of depressive-like disorders in humans often reported to be present animal models depression induced by stress or inflammatory challenges. However, chronic mild (CMS) clinically silent inflammation, during the recovery period after an infection, for example, coincident, but comparison behavioural molecular changes that underpin CMS vs a challenge impact combined is largely unexplored. Here, we examined whether...
The process of macrophage polarisation is involved in many pathologies such as anti-cancer immunity and autoimmune diseases. Polarized macrophages exhibit various levels plasticity when M2/M(IL-4) are reprogrammed into an M1-like phenotype following treatment with IFNγ and/or LPS. At the same time, M1 resistant to reprogramming presence M2-like stimuli. molecular mechanisms responsible for polarization, M2 macrophages, lack remain unknown. Here, we explored role Egr2 induction maintenance...
Using specific polyclonal antisera against c‐Fos, JunB, c‐Jun and JunD, we tried to identify the candidate transcription factors of immediate early gene family which may contribute molecular processes during contextual memory reconsolidation. For that purpose analyzed expression these proteins in hippocampus after retrieval a mouse model fear conditioning. A single exposure foot shock 0.8 mA was sufficient induce robust conditioning C57Bl/6N mice. In mice context dependent evoked marked...
A stress-induced decrease in sucrose preference rodents is regarded as an analog of anhedonia, a key symptom depression. We investigated the effects citalopram, administrated via drinking water (15 mg/kg/day), mouse model anhedonia. In this model, chronic stress induces anhedonia subset C57BL/6N mice, while remaining animals do not show hedonic deficit or other depressive-like behaviors, although they are exposed to same stressors anhedonic mice. Pre-stress and post-stress treatment with...
While brain serotonin (5-HT) function is implicated in gene-by-environment interaction (GxE) impacting the vulnerability-resilience continuum neuropsychiatric disorders, it remains elusive how interplay of altered 5-HT synthesis and environmental stressors linked to failure emotion regulation. Here, we investigated effect constitutively impaired on behavioral neuroendocrine responses unpredictable chronic mild stress (CMS) using a mouse model deficiency resulting from targeted inactivation...
Environmental factors can significantly affect disease prevalence, including neuropsychiatric disorders such as depression. The ratio of deuterium to protium in water shows substantial geographical variation, which could susceptibility. Thus the link between content and depression was investigated, both epidemiologically, a mouse model chronic mild stress. We performed correlation analysis tap rates regions USA. Next, we used 10-day stress paradigm test whether 2-week deuterium-depleted...
Although it has been demonstrated that cAMP pathway affect both adaptive and innate cell functions, the role of this in regulation T-cell mediated central nervous system (CNS) autoimmune inflammation, such as experimental encephalomyelitis (EAE), remains unclear. It is also unclear how function CD4 T cells vivo at site inflammation. We found adenylyl-cyclase activator Forskolin besides inhibition functions upregulated miR-124 CNS during EAE, which associated with M2 phenotype...
Stress is a common cause of neuropsychiatric disorders, evoking multiple behavioral, endocrine and neuro-immune deficits. Animal models have been extensively used to understand the mechanisms stress-related disorders develop novel strategies for their treatment. Complementing rodent clinical studies, zebrafish (Danio rerio) one most important model organisms in biomedicine. Rapidly becoming popular species stress neuroscience research, are highly sensitive both acute chronic stress, show...
Stress response is essential for the organism to quickly restore physiological homeostasis disturbed by various environmental insults. In addition well-established cascades, stress also evokes brain and behavioral responses. Aquatic animal models, including zebrafish (Danio rerio), have been extensively used probe pathobiological mechanisms of stress-related disorders. Here, we critically discuss use models studying modeling its disorders experimentally, with a particular cross-taxon focus...