A5012485291- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Pancreatic function and diabetes
- Regulation of Appetite and Obesity
- Liver Disease Diagnosis and Treatment
- Chemical Reactions and Isotopes
- Fatty Acid Research and Health
- Treatment of Major Depression
- Maternal Mental Health During Pregnancy and Postpartum
- Thyroid Disorders and Treatments
- Cardiovascular Disease and Adiposity
- Olfactory and Sensory Function Studies
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Ion channel regulation and function
- Animal testing and alternatives
- Adipose Tissue and Metabolism
- Medicinal Plants and Bioactive Compounds
- Immune Response and Inflammation
University of Lisbon
2012-2025
University of Coimbra
2016-2023
Sechenov University
2018-2022
Universidade Nova de Lisboa
2013-2022
Maastricht University
2012-2020
Environmental factors can significantly affect disease prevalence, including neuropsychiatric disorders such as depression. The ratio of deuterium to protium in water shows substantial geographical variation, which could susceptibility. Thus the link between content and depression was investigated, both epidemiologically, a mouse model chronic mild stress. We performed correlation analysis tap rates regions USA. Next, we used 10-day stress paradigm test whether 2-week deuterium-depleted...
Post-translational modifications of proteins via palmitoylation, a thioester linkage 16-carbon fatty acid to cysteine residue, reversibly increases their affinity for cholesterol-rich lipid rafts in membranes, changing function. Little is known about how altered palmitoylation affects function at the systemic level and contributes CNS pathology. However, recent studies suggested role downregulation palmitoyl acetyltransferase (DHHC) 21 gene expression development Major Depressive Disorder...
N-Methyl-d-aspartate receptor (NMDAR)-mediated neurotransmission in the hippocampus is implicated cognitive and emotional disturbances during stress-related disorders. Here, using quantitative RT-PCR, we investigated hippocampal expression of NR2A, NR2B NR1 subunit mRNAs a mouse stress paradigm that mimics clinically relevant conditions simultaneously affected emotionality hippocampus-dependent functions. A 2-week procedure, which comprised ethologically valid stressors, exposure to rat...
Multiple models of human neuropsychiatric pathologies have been generated during the last decades which frequently use chronic dosing. Unfortunately, some drug administration methods may result in undesirable effects creating analysis confounds hampering model validity and preclinical assay outcomes. Here, automated floating behaviour, a sign depressive-like state, revealed that mice, subjected to three-week intraperitoneal injection regimen, had increased floating. In order probe an...
Central thyroid hormone signaling is important in brain function/dysfunction, including affective disorders and depression. In contrast to 3,3',5-triiodo-L-thyronine (T3), the role of 3,5-diiodo-L-thyronine (T2), which until recently was considered an inactive metabolite T3, has not been studied these pathologies. However, both T3 T2 stimulate mitochondrial respiration, a factor counteracting pathogenesis depressive disorder, but cellular origins CNS, mechanisms, kinetics action for two...
Central insulin receptor-mediated signalling is attracting the growing attention of researchers because rapidly accumulating evidence implicating it in mechanisms plasticity, stress response and neuropsychiatric disorders including depression. Dicholine succinate (DS), a mitochondrial complex II substrate, was shown to enhance insulin-receptor mediated signaling neurons regarded as sensitizer neuronal receptor. Compounds enhancing transmission exert an antidepressant-like effect several...
The modern lifestyle is associated with exposure to "psychological" or "emotional" stress. A growing portion of the population exposed emotional stress that results in a high incidence anxiety disorders, serious social problem. With this rise, there need for understanding neurobiological causes stress-induced and offer safe remedies condition. Side effects existing pharmaceuticals necessitate search alternatives. Having fewer adverse than classic remedies, natural extract-based therapies can...
The interaction between brain serotonin (5-HT) deficiency and environmental adversity may predispose females to excessive aggression. Specifically, complete inactivation of the gene encoding tryptophan hydroxylase-2 (Tph2) results in absence neuronal 5-HT synthesis aggressiveness both male female null mutant (Tph2−/−) mice. In heterozygous mice (Tph2+/−), there is a moderate reduction levels, when they are exposed stress, exhibit increased Here, we Tph2+/− five-day rat predation stress...
Objective We sought to investigate the efficacy of oral dosing in mice with imipramine (7mg/kg/day) via water or food pellets, and compare its effects paradigms learned helplessness, locomotion, hedonic state, anxiety. Methods Water consumption were measured determine daily dosage C57BL/6N mice. Next, baseline scores for O-maze, dark/light box, sucrose tests measured. Mice then subjected a 4-week treatment voluntary ingestion drinking pellets containing imipramine. Lastly, all groups novel...
Background: Cardiovascular diseases (CVD) are the number one cause of death worldwide. Oxidative stress has been associated with cell and cardiac remodelling, hallmarks type 2 diabetes (DM) heart failure. Epicardial adipose tissue (EAT) is metabolically dynamic, it in constant crosstalk surrounding tissue, potentially modulating its function metabolism. However, several important cellular molecular processes specific to EAT patients disease, have not yet evaluated.Aim: Investigate...