A5031636756- Zebrafish Biomedical Research Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Neonatal and fetal brain pathology
- Fatty Acid Research and Health
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- Psychedelics and Drug Studies
- Spinal Cord Injury Research
- Genetics, Aging, and Longevity in Model Organisms
- Lysosomal Storage Disorders Research
- Memory and Neural Mechanisms
- RNA Research and Splicing
- Neurobiology and Insect Physiology Research
- RNA and protein synthesis mechanisms
- Neuroendocrine regulation and behavior
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- Trypanosoma species research and implications
- Nicotinic Acetylcholine Receptors Study
Institute of Experimental Medicine
2021-2025
Ministry of Health of the Russian Federation
2020-2025
Federal Almazov North-West Medical Research Centre
2023-2025
St Petersburg University
2020-2025
Czech Academy of Sciences, Institute of Experimental Medicine
2024
Russian Scientific Center of Radiology and Surgical Technologies
2020-2023
Yerevan State Medical University
2023
Institute of Physiology and Basic Medicine
2020
Russian Academy of Sciences
2019-2020
Northern (Arctic) Federal University
2019-2020
Abstract Stress-related neuropsychiatric disorders are widespread, debilitating and often treatment-resistant illnesses that represent an urgent unmet biomedical problem. Animal models of these widely used to study stress pathogenesis. A more recent historically less utilized model organism, the zebrafish ( Danio rerio ), is a valuable tool in neuroscience research. Utilizing 5-week chronic unpredictable (CUS) model, here we examined brain transcriptomic profiles complex dynamic behavioral...
Hallucinogenic drugs potently affect brain and behavior have also recently emerged as potentially promising agents in pharmacotherapy. Complementing laboratory rodents, the zebrafish (Danio rerio) is a powerful animal model organism for screening neuroactive drugs, including hallucinogens. Here, we test battery of ten novel N-benzyl-2-phenylethylamine (NBPEA) derivatives with 2,4- 3,4-dimethoxy substitutions phenethylamine moiety −OCH3, −OCF3, −F, −Cl, −Br ortho position phenyl ring N-benzyl...
Abstract Long-term recurrent stress is a common cause of neuropsychiatric disorders. Animal models are widely used to study the pathogenesis stress-related psychiatric The zebrafish ( Danio rerio ) emerging as powerful tool chronic and its mechanisms. Here, we developed prolonged 11-week unpredictable (PCUS) model in more fully mimic human populations. We also examined behavioral neurochemical alterations zebrafish, attempted modulate these states by 3-week treatment with an antidepressant...
Traumatic brain injury (TBI) is a serious biomedical problem with high prevalence and mortality risks. Understanding TBI in traditional (e.g., rodent) animal models often presents challenges due to the complexity of their its limited regenerative capabilities. Here, we present novel data obtained using zebrafish model based on stab wound telencephalon, aiming investigate behavioral molecular consequences zebrafish. Four days following injury, adult displayed hypolocomotion seen tank test...
Potently affecting human and animal brain behavior, hallucinogenic drugs have recently emerged as potentially promising agents in psychopharmacotherapy. Complementing laboratory rodents, the zebrafish (Danio rerio) is a powerful model organism for screening neuroactive drugs, including hallucinogens. Here, we tested four novel N-benzyl-2-phenylethylamine (NBPEA) derivatives with 2,4- 3,4-dimethoxy substitutions phenethylamine moiety -F, -Cl, -OCF3 ortho position of phenyl ring N-benzyl...
<title>Abstract</title> The reproducibility crisis in bioscience, characterized by inconsistent study results, impedes our understanding of biological processes and global collaborative studies offer a unique solution. This is the first collaboration using zebrafish (Danio rerio) novel tank test, behavioral assay for anxiety-like responses. We analyzed data from 20 laboratories worldwide, focusing on housing conditions experimental setups. Our included 488 adult zebrafish, tested 5 min,...
Widespread, debilitating and often treatment-resistant, depression other stress-related neuropsychiatric disorders represent an urgent unmet biomedical societal problem. Although animal models of these are commonly used to study stress pathogenesis, they difficult translate across species into valuable meaningful clinically relevant data. To address this problem, here we utilized several cross-species/cross-taxon approaches identify potential evolutionarily conserved differentially expressed...