A5033242799- Zebrafish Biomedical Research Applications
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Regulation of Appetite and Obesity
- Neonatal and fetal brain pathology
- Fish biology, ecology, and behavior
- Adipose Tissue and Metabolism
- Retinal Development and Disorders
- Physiological and biochemical adaptations
- Neuroinflammation and Neurodegeneration Mechanisms
- CRISPR and Genetic Engineering
- Fish Biology and Ecology Studies
- Signaling Pathways in Disease
- Stress Responses and Cortisol
- Aquaculture Nutrition and Growth
- Apelin-related biomedical research
- Congenital heart defects research
- Coronary Artery Anomalies
- Cardiovascular Effects of Exercise
- Fish Ecology and Management Studies
- Fatty Acid Research and Health
- Science, Research, and Medicine
- Genetics, Aging, and Longevity in Model Organisms
- Birth, Development, and Health
- MicroRNA in disease regulation
Queen Mary University of London
2022-2024
University of Naples Federico II
2018-2022
Abstract RBFOX1 is a highly pleiotropic gene that contributes to several psychiatric and neurodevelopmental disorders. Both rare common variants in have been associated with conditions, but the mechanisms underlying effects of are not yet understood. Here we found that, zebrafish, rbfox1 expressed spinal cord, mid- hindbrain during developmental stages. In adults, expression restricted specific areas brain, including telencephalic diencephalic regions an important role receiving processing...
The development of effective neurological treatments remains a challenge due to the low permeation across blood-brain barrier (BBB). use nanoparticles for brain drug delivery is promising, but level BBB crossing low, typically around 0.5-3%. We report synthesis negatively charged N-isopropylacrylamide nanogels (diameter 10 nm) displaying in vitro human model nearly 5-fold higher than previously reported, and permeating parenchyma healthy zebrafish with fully formed BBB....
Abstract Nerve growth factor ( NGF ), a member of the neurotrophin family, was initially described as neuronal survival and factor, but successively has emerged an active mediator in many essential functions central nervous system mammals. is synthesized precursor pro‐ cleaved intracellularly into mature . However, recent evidence demonstrates that not simple inactive precursor, also secreted outside cells can exert multiple roles. Despite vast literature present mammals, studies devoted to...
Neurotrophins contribute to the complexity of vertebrate nervous system, being involved in cognition and memory. Abnormalities associated with neurotrophin synthesis may lead neuropathies, neurodegenerative disorders age-associated cognitive decline. The genome teleost fishes contains homologs some mammalian neurotrophins as well a gene coding for an additional (NT-6). In this study, we characterized specific short-lived fish Nothobranchius furzeri, relatively new model aging studies. Thus,...
<title>Abstract</title> The reproducibility crisis in bioscience, characterized by inconsistent study results, impedes our understanding of biological processes and global collaborative studies offer a unique solution. This is the first collaboration using zebrafish (Danio rerio) novel tank test, behavioral assay for anxiety-like responses. We analyzed data from 20 laboratories worldwide, focusing on housing conditions experimental setups. Our included 488 adult zebrafish, tested 5 min,...
Nesfatin-1 (Nesf-1) was identified as an anorexigenic and well conserved molecule in rodents fish. While tissue distribution of NUCB2 (Nucleobindin 2)/Nesf-1 is discretely known vertebrates, reports on ontogenetic expression are scarce. Here, we examine the age-related central peripheral NUCB2/Nesf-1 teleost African turquoise killifish Nothobranchius furzeri, a consolidated model organism for aging research. We focused our analysis brain areas responsible regulation food intake rostral...
Ankyrin repeat and kinase domain containing 1 (ANKK1) is a member of the receptor-interacting protein serine/threonine family, known to be involved in cell proliferation, differentiation activation transcription factors. Genetic variation within ANKK1 locus suggested play role vulnerability addictions. However, mechanism action still poorly understood. It has been that may affect development and/or functioning dopaminergic pathways. To test this hypothesis, we generated CRISPR-Cas9 loss...
Nesfatin-1(Nesf-1) is an anorexigenic peptide involved in the regulation of homeostatic feeding. Nesf-1 expressed central nervous system and other organs, including pancreas, where it promotes release insulin from β-cells. This raises possibility that Nesf-1dysfunction could be metabolic disorders, particularly type 2 diabetes mellitus (T2D). Recently, has been discovered dolphins can a natural animal model fully replicates human T2D, due to its prolonged glucose tolerance curve maintanaince...
Collagens are the most abundant proteins in vertebrates and constitute major components of extracellular matrix. play an important multifaceted role development functioning nervous system undergo structural remodeling quantitative modifications during aging. Here, we investigated age-dependent regulation col4a1 col25a1 brain short-lived vertebrate Nothobranchius furzeri, a powerful model organism for aging research due to its natural fast-aging process further characterized typical hallmarks...
ABSTRACT RBFOX1 is a highly pleiotropic gene that contributes to several psychiatric and neurodevelopmental disorders. Both rare common variants in have been associated with conditions, but the mechanisms underlying effects of are not yet understood. Here we found that, zebrafish, rbfox1 expressed spinal cord, mid- hindbrain during developmental stages. In adults, expression restricted specific areas brain, including telencephalic diencephalic regions an important role receiving processing...
Nerve growth factor (NGF) receptors are evolutionary conserved molecules, and in mammals considered necessary for ensuring the survival of cholinergic neurons. The age-dependent regulation NTRK1/NTRKA p75/NGFR mammalian brain results a reduced response neurons to neurotrophic factors is thought play role pathogenesis neurodegenerative diseases. Here, we study expression NGF (NTRK1/NTRKA p75/NGFR) short-lived teleost fish Nothobranchius furzeri. We observed that more expressed than young old...
ABSTRACT RBFOX1 regulates transcriptional networks linked to synaptic transmission and neurodevelopment. Mutations in the gene are associated with psychiatric disorders but how influences disorder vulnerability remains unclear. Recent studies showed that mediates alternative splicing of PAC1 , a critical HPA axis activator. Further, dysfunction is dysregulation BDNF/TrkB, pathway promoting neuroplasticity, neuronal survival, stress resilience. Hence, may increase via dysregulation, leading...
Abstract Inhibitors of DNA (Id) are key transcription factors (TFs) regulating neurogenic processes. They belong to the helix‐loop‐helix (HLH) TF family and dominant negative regulators basic HLH proteins (bHLHs). Specifically, they inhibit cell differentiation enhance proliferation motility. The Id includes four members, Id1 , Id2 Id3 Id4 which have been identified in nearly all vertebrates. transcript catalog African turquoise killifish, Nothobranchius furzeri contains TFs has evolved...
Abstract Disclosure: X. Wang: None. A. Leggieri: S. Anagianni: C.H. Brennan: M. Korbonits: Background: Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene account for 10% of cases with familial isolated pituitary adenoma (FIPA). The main features patients carrying heterozygous AIP mutations include young-onset, large and invasive growth hormone and/or prolactin-secreting tumours, although a milder spectrum presentation has been also described. In several animal models...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)