A5081667687- Zebrafish Biomedical Research Applications
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Parkinson's Disease Mechanisms and Treatments
- Hypothalamic control of reproductive hormones
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
- Autism Spectrum Disorder Research
- Hormonal and reproductive studies
- Autophagy in Disease and Therapy
- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Genetics and Neurodevelopmental Disorders
- Nanopore and Nanochannel Transport Studies
- Congenital heart defects research
- Phosphodiesterase function and regulation
- Neurological Disorders and Treatments
Scientific Research Institute of Biochemistry
2020-2025
Institute of Physiology and Basic Medicine
2014-2024
Institute of Cytology and Genetics
2005-2024
Novosibirsk State University
1997-2024
Siberian Branch of the Russian Academy of Sciences
2008-2024
Neuroscience Institute
2022
Clinical Research Consortium
2018-2021
Research Institute of Physiology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Medical Sciences
2003-2016
Russian Academy of Sciences
2001-2014
Academy of Medical Sciences
2004
Stress response is essential for the organism to quickly restore physiological homeostasis disturbed by various environmental insults. In addition well-established cascades, stress also evokes brain and behavioral responses. Aquatic animal models, including zebrafish (Danio rerio), have been extensively used probe pathobiological mechanisms of stress-related disorders. Here, we critically discuss use models studying modeling its disorders experimentally, with a particular cross-taxon focus...
ABSTRACT Inducing multiple neurobehavioural and neurochemical deficits, olfactory bulbectomy (OBX) has been developed as a rodent model of depression with potential for antidepressant drug screening. However, the generality this in other vertebrate taxa remains poorly understood. A small freshwater teleost fish, zebrafish ( Danio rerio ), is rapidly becoming common species neuroscience research. Capitalizing on recently noninvasive targeted laser ablation brain, here we report an OBX adult...
Functional foods enriched with plant polyphenols and anthocyanins in particular attract special attention due to multiple beneficial bioactive properties of the latter. We evaluated effects a grain diet rich mouse model Alzheimer’s disease induced by amyloid-beta (Aβ) transgenic Parkinson’s (PD) overexpression human alpha-synuclein. The mice were kept at that consisted wheat near isogenic lines differing anthocyanin content for five–six months. anthocyanin-rich was safe possessed positive on...
Abstract Stress-related neuropsychiatric disorders are widespread, debilitating and often treatment-resistant illnesses that represent an urgent unmet biomedical problem. Animal models of these widely used to study stress pathogenesis. A more recent historically less utilized model organism, the zebrafish ( Danio rerio ), is a valuable tool in neuroscience research. Utilizing 5-week chronic unpredictable (CUS) model, here we examined brain transcriptomic profiles complex dynamic behavioral...
Autophagy attenuation has been found in neurodegenerative diseases, aging, diabetes mellitus, and atherosclerosis. In experimental models of the correction autophagy brain reverses neuronal behavioral deficits hence seems to be a promising therapy for neuropathologies. Our aim was study effect an inducer, trehalose, on behavior genetic model with signs damage (db/db mice). A 2% trehalose solution administered as drinking water during 24 days experiment. Expressions markers (LC3-II),...