A5074080610- Autophagy in Disease and Therapy
- Lysosomal Storage Disorders Research
- Liver Disease Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Biomedical Research and Pathophysiology
- Alzheimer's disease research and treatments
- Retinoids in leukemia and cellular processes
- Mitochondrial Function and Pathology
- Cannabis and Cannabinoid Research
- Erythrocyte Function and Pathophysiology
- Advanced Glycation End Products research
- Neonatal Health and Biochemistry
- Drug-Induced Hepatotoxicity and Protection
- Toxin Mechanisms and Immunotoxins
- Sleep and Wakefulness Research
- Genetic Neurodegenerative Diseases
- Diet and metabolism studies
- Alkaline Phosphatase Research Studies
- Amyotrophic Lateral Sclerosis Research
- Endoplasmic Reticulum Stress and Disease
- Neurological disorders and treatments
- Neurological Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Chronic Kidney Disease and Diabetes
Scientific Research Institute of Biochemistry
2023
Institute of Physiology and Basic Medicine
2017-2020
Novosibirsk State Medical University
1981-2017
Ministry of Health of the Russian Federation
2016-2017
Research Institute of Physiology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Medical Sciences
2016
Central State Medical Academy
2002
Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in the majority lung cancer. This study aims at defining connections between STAT3 function malignant properties non-small cell carcinoma (NSCLC) cells. To address possible mechanisms by which influences invasiveness, expression matrix metalloproteinase-1 (MMP-1) was analyzed correlated with activity status. Studies on both surgical biopsies cancer lines revealed a coincidence activation strong MMP-1....
Autophagy attenuation has been found in neurodegenerative diseases, aging, diabetes mellitus, and atherosclerosis. In experimental models of the correction autophagy brain reverses neuronal behavioral deficits hence seems to be a promising therapy for neuropathologies. Our aim was study effect an inducer, trehalose, on behavior genetic model with signs damage (db/db mice). A 2% trehalose solution administered as drinking water during 24 days experiment. Expressions markers (LC3-II),...
In the treatment of experimental neurodegeneration with disaccharide trehalose, various regimens are used, predominantly a 2% solution, drunk for several weeks. We studied effects different dietary trehalose in an amyloid-β (Aβ) 25–35-induced murine model Alzheimer’s disease (AD). Aβ-treated mice received solution daily, 4% daily (continuous mode) or every other day (intermittent mode), to drink two revealed dose-dependent on autophagy activation frontal cortex and hippocampus, restoration...
Abstract Pathological aggregation and accumulation of α-synuclein in neurons play a core role Parkinson’s disease (PD) while its overexpression is common PD model. Autophagy-lysosomal pathways are general intraneural mechanisms protein clearance. Earlier suppressed autophagy the brain young transgenic mice overexpressing А53Т-mutant human (mut(PD)) was revealed. Previous studies have recognized that Cystatin C displays protective activity against neurodegeneration. This cysteine protease...
Autophagy is a dynamic cellular process involved in the turnover of proteins, protein complexes, and organelles through lysosomal degradation. It particularly important neurons, which do not have proliferative option for repair. has been shown to be suppressed striatum transgenic mouse model Parkinson’s disease. Cystatin C one potent regulators autophagy. Changes expression secretion cystatin brain amyotrophic lateral sclerosis, Alzheimer’s diseases, some animal models neurodegeneration,...
For the determining of role clinical data and integral laboratory indices in valuation endogenic intoxication (EI) chronic hepatitis B (HHB) 100 patients 20 healthy adults were examined. The present symptoms disease facts about character communication somatic diseases studied effective concentration albumin (ECA) reserve binding (RAB) defined by fluorescence method twice at 18—20 days interval. lowering average ECA RAB was revealed HHB comparison with control group (p < 0,05), this stable...