A5059577045- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neurological Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Schizophrenia research and treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neuroendocrine regulation and behavior
- Psychosomatic Disorders and Their Treatments
- Bipolar Disorder and Treatment
- Electroconvulsive Therapy Studies
- Diet and metabolism studies
- Mental Health and Psychiatry
- Human Health and Disease
- S100 Proteins and Annexins
- Autism Spectrum Disorder Research
- Inflammasome and immune disorders
- Long-Term Effects of COVID-19
- Health, psychology, and well-being
- GDF15 and Related Biomarkers
- Neurological Disease Mechanisms and Treatments
- Intensive Care Unit Cognitive Disorders
- Suicide and Self-Harm Studies
- Biomarkers in Disease Mechanisms
- COVID-19 and Mental Health
Mental Health Research Center of Russian Academy of Medical Sciences
2014-2024
Mental Health Research Institute
2022-2023
Russian Academy of Sciences
2013
Academy of Medical Sciences
2013
Importance No clinically applicable diagnostic test exists for severe mental disorders. Lipids harbor potential as disease markers. Objective To define a reproducible profile of lipid alterations in the blood plasma patients with schizophrenia (SCZ) independent demographic and environmental variables to investigate its specificity association other psychiatric disorders, ie, major depressive disorder (MDD) bipolar (BPD). Design, Setting, Participants This was multicohort case-control...
Background: according to the numerous data complement system (CS) is involved in many mental disorders pathological process development. However, results are contradictory and require new methodological approaches being established.One way of studying CS components impact on schizophrenia development elaborated by authors method assessing functional activity recording biological objects Tetrahymena pyriformis ciliates death serum/plasma solutions through cascade formation terminal component...
The objective : of the study was to present main provisions a new clinical and biological model schizophrenia, which establishes links between disorders in field processes formation positive negative general psychopathological space schizophrenia on basis analysis long-term results research Mental Health Research Centre. Material method: by keywords “schizophrenia”, “biological hypotheses schizophrenia”, “neuroinflammation”, “neurodegeneration”; “positive disorders”, “negative “neuroimmune...
In the treatment of experimental neurodegeneration with disaccharide trehalose, various regimens are used, predominantly a 2% solution, drunk for several weeks. We studied effects different dietary trehalose in an amyloid-β (Aβ) 25–35-induced murine model Alzheimer’s disease (AD). Aβ-treated mice received solution daily, 4% daily (continuous mode) or every other day (intermittent mode), to drink two revealed dose-dependent on autophagy activation frontal cortex and hippocampus, restoration...
<h3>ЦЕЛЬ ИССЛЕДОВАНИЯ</h3> Определение маркеров воспаления: энзиматической активности лейкоцитарной эластазы (ЛЭ); функциональной α1- протеиназного ингибитора (α1-ПИ); аутоантител к нейротрофину S100b и основному белку миелина (ОБМ) в плазме крови больных шизофренией пожилого молодого возраста сопоставлении с клиническими особенностями течения шизофренического процесса. <h3>МАТЕРИАЛ И МЕТОДЫ</h3> Обследованы больные двух возрастных групп: 1-ю группу вошли 19 женщин возрасте от 60 до 78 лет...
We investigated the associations of DRD3 rs6280, HTR1A rs6295, BDNF rs6265, SCL6A4 rs16965628, and 5HT2A rs7322347 with schizophrenia in a case–control study, these genetic variants several clinical features. also markers inflammatory response (C-reactive protein, IL-2, IL-6, IL-10), activity leukocytic elastase (LE) α1-proteinase inhibitor (a1-PI), antibodies to S100B myelin basic protein (MBP) schizophrenia. Clinical symptoms were assessed on three scales: Positive Negative Syndrome Scale,...
Background : insufficient study of heterogeneous delusional disorders in schizophrenia and the role inflammation development disease served as basis for this study. The aim to establish immune mechanisms processes interaction different forms symptom complexes schizophrenia. Patients 60 patients (mean age 38.4 ± 1.11 years) with diagnosis “paranoid schizophrenia, continuous progressive course” (F20.00, ICD-10) were included state was defined by persistent delusional/hallucinatory disorders....
The aim of the study was to assess impact coronavirus infection on clinical, neurophysiological and neuroimmunological parameters, as well their interrelations in young female depressive patients. Patients : a comparative analysis quantitative clinical (according HDRS-17 scale), (EEG) “Neuro-immuno-test” technology) parameters carried out two groups patients aged 16–25 years. first group included 46 who recovered from mild or asymptomatic (“COVID” group). second 40 were studied treated before...
To determine a complex of immune markers reflecting various links multicomponent inflammatory reactions in amnestic type mild cognitive impairment (aMCI) comparison with Alzheimer's disease (AD).Sixty-seven patients aMCI, aged 72 [63; 77] years, and 91 at the age 74 [68; 79] years were examined. The aMCI was diagnosed according to criteria R.S. Petersen et al. (1999) B. Dubois (2014). diagnosis AD established accordance ICD-10 NINCDS-ADRDA criteria. degree dementia severity determined by...
<h3>ЦЕЛЬ ИССЛЕДОВАНИЯ</h3> Изучение клинико-психопатологических и иммунологических особенностей становления ремиссии после первого психотического приступа в юношеском возрасте для определения закономерностей развития этого этапа возможности использования полученных результатов мониторинга, прогноза оптимизации проведенной терапии. <h3>МАТЕРИАЛ И МЕТОДЫ</h3> Обследованы 50 пациентов мужского пола юношеского возраста — от 16 до 25 лет (средний возраст 20,8±2,2 года), перенесших первый...
Relevance. Objective comparison of biological markers and real clinical presentation is especially difficult in mental disorders, which are classified according to a large number diagnostic criteria wide variety symptoms. Therefore, the development an effective system biochemical assessment their relationship optimize diagnosis treatment schizophrenia relevant. The aim study was develop statistical model that combines known tested for illnesses patients with schizophrenia. Materials methods....
To identify clinical, psychopathological, and immunological features of the asthenic symptom-complex in patients with schizophrenia to analyze possibility optimizing complex therapy these conditions using immunotropic drug bestim.Forty-three male patients, aged 20-55 years, were examined. Clinical examination (PANSS, MFI-20) was performed before, 5, 30 days after end treatment. The activity inflammatory markers (leukocyte elastase (LE) a1-proteinase inhibitor (a1-PI)) determined blood...
To assess the risk of thrombotic events in patients with schizophrenia and schizoaffective disorder based on 'fibrinodynamics' technology.A group 76 women, including 38 paranoid (F20.0), 18 (F25.1) acute stage, 20 healthy controls, participated study. The technology includes study coagulation fibrinolysis, Karmin author software, calculation peak time hemostasis potential spontaneous clots. Growth lysis fibrin clots were studied plasma purified from platelets. All preanalytic procedures...
The aim of the study was to investigate chronic inammation and genetic predisposition processes, involved in formation psychopathological dimensions schizophrenia spectrum disorders on catatonia model. Method: analysis PubMed/MEDLINE, RSCI other sources databases genetics immunology comparison with results our own clinical biological studies catatonic as a model heterogeneity positive disorders, well various mechanisms their formation. Results: obtained demonstrate involvement inammatory...
The aim of the study is to clinical features asthenic disorders in chronic heart failure (CHF) considering reaction disease.62 inpatients with CHF II-IV functional class (FC) according NYHA were examined. Research methods included somatic, psychopathological and pathopsychological examination using psychometric scales.According a Multidimensional Fatigue Inventory (MFI-20), discovered all examined patients, realized mainly by «general fatigue» (75.8%) «physical (72.6%), more rarely «mental...
Background: there is a two-way relationship between the gut microbiota (GM) and brain, both in normal pathological conditions. It has been suggested that disturbances GM composition function can lead to activation of (neuro) inflammation or its maintenance mental disorders. Objective: analysis scientific publications, including results our own research on microbiota, role modulation brain functions involvement (neuro)inflammation endogenous Material method: using keywords “gut–microbiota”...
Objective The comparison of inflammatory markers in different age groups patients with endogenous depression and correlation immunological parameters the clinical features depression. Material methods study included 140 (ED) (F21, F31-F34, ICD-10) aged 15 to 82 years (39.8±23 years), including 55 adolescent (18.9±2.8 30 middle-aged (38.7±10.3 years) elderly (69.1±7.1 years). total duration disease differed from 5 months 45 years. Psychometric assessment was carried out using HDRS. control...
Schizophrenia is a serious mental disorder requiring lifelong treatment. While medications are available that effective in treating some patients, individual treatment responses can vary, with patients exhibiting resistance to one or multiple drugs. Currently, little known about the causes of difference response observed among individuals schizophrenia, and satisfactory markers poor not for clinical practice. Here, we studied changes levels 322 blood plasma lipids between two time points...
The clinical and immunological study of the potential impact coronavirus infection on course endogenous psychosis.Thirty-three female patients, aged 16 to 48 years, with depressive-delusional conditions (ICD-10 F20.01, F21, F31) developed after infection, whom 15 people (group 1) had states 1-2 months COVID-19 18 2), who similar psychoses in later periods (2-6 months). severity psychopathologic symptoms was evaluated PANSS HDRS-21 scales. activity inflammatory markers - leukocyte elastase...
At present, at least two phenotypically different subpopulations of blood monocytes have been identified: "classical" with the phenotype CD14 ++ /CD16 - and "nonclassical" (pro-inflammatory) + . It has established that participate in latent or so-called systemic non-infectious inflammation human body along neutrophils microglial cells brain, which are analogue monocyte/macrophage system brain. Monocyte function disorders considered as one links neurodegenerative process underlying...
INTRODUCTION: Schizophrenia, although a debilitating mental illness, greatly affects individuals physical health as well. One of the leading somatic comorbidities associated with schizophrenia is cardiovascular disease, which has been estimated to be one causes excess mortality in patients diagnosed schizophrenia. Although shared susceptibility and disease well established, mechanisms linking these two disorders are not understood. Genetic studies have hinted toward lipid metabolism...
To determine the indicators of systemic inflammation in peripheral blood samples patients with organic non-psychotic disorders.The study included 60 patients, aged 56.9±7.7 years, a disease duration 7.3±5.55 verified ICD-10 diagnosis «Organic emotionally labile (asthenic) disorder» (F06.6) and Anxiety Disorder» (F06.4). Patients asthenic disorder were divided into two groups according to prevailing symptoms: 36 asthenic-cephalgic syndrome (AC); 10 astheno-dysthymic (AD); third group (n=14)...
To determine the levels of pro-inflammatory and anti-inflammatory cytokines inflammatory markers such as C-reactive protein, leukocyte elastase, α1-proteinase inhibitor, autoantibodies to neuroantigens in blood patients with adolescent depression clinical high risk for psychosis (CHR-P) study relation these biological features psychopathological symptomatology patients.Eighty young adults, aged 16-24 years, first depressive episode (F32.1-2, F32.38, F32.8) were studied. Based on presence...