A5102942537- Neurological Disorders and Treatments
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Healthcare Systems and Public Health
- Lymphoma Diagnosis and Treatment
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- CAR-T cell therapy research
- Neurological Disease Mechanisms and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Mental Health and Psychiatry
- Mental Health Research Topics
- RNA regulation and disease
- Cancer Immunotherapy and Biomarkers
- Aging, Elder Care, and Social Issues
- Stress Responses and Cortisol
- Aging and Gerontology Research
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Medicinal Plants and Neuroprotection
- RNA and protein synthesis mechanisms
- Health, psychology, and well-being
- Viral-associated cancers and disorders
- RNA Research and Splicing
- Technology and Human Factors in Education and Health
Mental Health Research Center of Russian Academy of Medical Sciences
2008-2024
First Pavlov State Medical University of St. Petersburg
2023
Abstract Objectives Dementia is a rapidly growing public health problem in low and middle income countries. There an urgent need, the absence of formal services, to develop interventions designed improve lives people with dementia, their families. This study tests effectiveness 10/66 caregiver intervention among carers. Design A single blind parallel group randomized controlled trial (ISRCTN41039907). Setting Moscow. Participants Sixty family caregivers aged 65 over dementia were receive...
Abstract PTCLs are aggressive hematologic malignancies often with poor prognoses; for patients R/R PTCL there is no standard-of-care therapy and novel treatments required. AFM13 a tetravalent, bispecific Innate Cell Engager (ICE ® ) that binds CD30 when expressed on cells, CD16A innate effector redirecting enhancing the immune response to CD30+ tumor cells. Phase 1 clinical studies of in Hodgkin lymphoma cutaneous lymphomas showed tolerable safety profile activity; early correlative science...
To determine a complex of immune markers reflecting various links multicomponent inflammatory reactions in amnestic type mild cognitive impairment (aMCI) comparison with Alzheimer's disease (AD).Sixty-seven patients aMCI, aged 72 [63; 77] years, and 91 at the age 74 [68; 79] years were examined. The aMCI was diagnosed according to criteria R.S. Petersen et al. (1999) B. Dubois (2014). diagnosis AD established accordance ICD-10 NINCDS-ADRDA criteria. degree dementia severity determined by...
Evaluation of the efficacy and safety drug Acatinol Memantine, 20 mg (once daily) in comparison with 10 (twice patients moderate to severe vascular dementia.
Topic: 19. Aggressive Non-Hodgkin lymphoma - Clinical Background: PTCLs are a group of aggressive hematologic malignancies with generally poor prognoses. No standard-of-care therapy is established for patients relapsed or refractory (R/R) PTCL and novel treatments required. AFM13, tetravalent, bispecific Innate Cell Engager (ICE®), has shown well-managed safety profile promising clinical efficacy in Phase 1 studies involving R/R Hodgkin (HL) cutaneous CD30‑positive (CD30+) lymphomas. ICE®...
To quantify the relationship of Alzheimer's disease with inflammatory markers: enzymatic activity leukocyte elastase (LE) and functional α1-proteinase inhibitor (α1-PI) on basis logistic regression model to build a predict probability AD in patients mild cognitive impairment (MCI).The object mathematical analysis was database, which included results assays LE α1-PI blood plasma 91 verified diagnosis inpatient or outpatient treatment 37 age-matched healthy people.The connecting is built. The...
Background: as the most common form of dementia, Alzheimer’s disease (AD) is characterized by cognitive deterioration and usually begins with loss memory recent events. It important to search for biological, sensitive affordable methods that could be used early diagnostics AD determine severity disease. Objective: develop machine learning algorithms based on such inflammatory markers enzymatic activity leukocyte elastase (LE) functional α1-proteinase inhibitor (α1-PI) diagnosing assessing...
Background: the role of sex factor in differences between manifestations normality and pathology is not limited to phenomenon sexual dimorphism. It known that prevalence certain diseases males females different, particular, there a multiple increase incidence dementia compared Alzheimer’s disease (AD). Taking into account neuroinflammation pathogenesis neurodegenerative diseases, reason assume gender inflammation indicators at different stages AD. The aim study was conduct comparative...
Background: the clinical experience testifies to fact, that increase of dementia severity in late age occurs quickly some cases and others it proceeds slowly, which is reflected total duration disease survival. One aspects dementias research study significant differences progression rates. The objective review was generalize obtained data on rates various genesis, first all due Alzheimer’s its associated disorders. Material methods: papers MedLine/PubMed bases from1990 2020 were selected...
Topic: 19. Aggressive Non-Hodgkin lymphoma - Clinical Background: Primary large B-cell of immune-privileged sites (PLBLIPS) encompass primary central nervous system (PLCNS) and testicular (PTL) which are characterized by alterations the 9p24 locus leading to increased PD-L1 expression on tumor cells. Chapuy et al. demonstrated that systemic diffuse (DLBCL) with involvement CNS (SLCNS) or testis is generally belonged C5 subtype has mutational profile similar PLCNS PTL. In all mentioned...
Background : It is well known, that old age dementias steadily grow progressively worse and inevitably lead to fatal outcome. Mortality indices in foreign research largely vary, they are practically absent domestic scientific studies, official statistical data on the prevalence of dementia cause death do not reflect real situation. The Objective study was perform analysis completed cases late from materials observations Alzheimer’s disease center Mental Health Research Center. Patients...
Research of the last decade established that inflammatory reactions are involved in pathogenesis Alzheimer's disease (AD) and schizophrenia (Sch). The aim this paper to carry out a comparative analysis some inflammation mediators [activity leukocyte elastase (LE) alpha 1- proteinase inhibitor (α1-PI), level CRP, IL-6 IL-10] blood serum patients with AD old aged comparison healthy control same age. There were significant increase activity α1-PI, IL-10 (p<0.0001, p<0.05, p<0.01, respectively)...
Background : steady progression of dementia is characterized with various rates, which specified clinical differentiation dementias rapid and slow increase cognitive decline severity. The search for factors, hypothetically responsible differences in late age rate, one the aspects investigation dementias. objective was to generalize results study separate factors effect on rate. Material methods papers MEDLINE/PubMed bases from 1990 2020 were selected analyzed according key words: “late age”,...
Introduction: PTCLs are aggressive hematologic malignancies often with poor prognoses; there is no standard of care therapy for patients R/R PTCL. AFM13, a tetravalent, bispecific innate cell engager, binds CD30 when expressed on PTCL cells, and CD16A effector augmenting the immune response to CD30+ tumor cells. Phase 1 clinical trials AFM13 in Hodgkin lymphoma (HL) cutaneous CD30+lymphomas showed tolerable safety profile activity; correlative science data small group AFM13-responsive HL...
The review of publications on an influence demographic changes in the population prevalence old age dementias and a scale burden modern society are presented. This paper is first part review. It presents necessity new forms out-patient care to aged with cognitive impairment. author reviews history creation memory clinics Alzheimer's disease centers.Представлен обзор научных публикаций о влиянии демографических изменений в населении на распространенность деменций позднего возраста и масштаб...
Introduction The creation of mathematical models for determining the risk Alzheimer’s disease in patients with mild cognitive impairment based on immune markers blood is important differential diagnosis AD, assessment clinical state at different stages disease, and optimization therapy. Objectives To assess AD amnestic type (aMCI) use such inflammation as enzymatic activity leukocyte elastase (LE) functional α1-proteinase inhibitor (α1-PI). Methods object analysis basis cluster logistic...
The aim of the paper was to provide an overview reports presented at congress on main problems clinical and biological psychiatry . Discussion conclusion : A representative forum domestic psychiatrists narcologists, psychotherapists psychologists, organizers psychiatric care leading scientists in fi eld held together with Regional Congress World Psychiatric Association (WPA). thematic diversity corresponded problem, refl ected title congress. opportunity review discuss achievements scientifi...