A5057947405- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Neurological Disorders and Treatments
- Mental Health and Psychiatry
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Digestive system and related health
- Human Health and Disease
- Stress Responses and Cortisol
- Electroconvulsive Therapy Studies
- Treatment of Major Depression
- Vibrio bacteria research studies
- Erythrocyte Function and Pathophysiology
- HIV, TB, and STIs Epidemiology
- Macrophage Migration Inhibitory Factor
- Obsessive-Compulsive Spectrum Disorders
- Social and Behavioral Studies
- Healthcare cost, quality, practices
- Stroke Rehabilitation and Recovery
- Atrial Fibrillation Management and Outcomes
- Protein purification and stability
- Nerve injury and regeneration
- Advanced Proteomics Techniques and Applications
- Mosquito-borne diseases and control
Mental Health Research Center of Russian Academy of Medical Sciences
2011-2021
Russian Academy of Sciences
1966-2019
Academy of Medical Sciences
2010
To detect blood plasma coagulability in children with mental diseases using a thrombodynamics test.The study included two groups of children. Group 1 11 patients infantile psychosis autism (F84.02) (4 girls and 7 boys). 2 8 childhood schizophrenia (F20.8xx3) 14 A test was performed T-2 Thrombodynamics analyzer (LLC Hemacore, Moscow, Russia).Thrombodynamic parameters, such as initial, steady-state velocity spontaneous clots adjusted (Vi, Vst V, μm/min, respectively) clot size at 30 minute (CS...
To assess the risk of thrombotic events in patients with schizophrenia and schizoaffective disorder based on 'fibrinodynamics' technology.A group 76 women, including 38 paranoid (F20.0), 18 (F25.1) acute stage, 20 healthy controls, participated study. The technology includes study coagulation fibrinolysis, Karmin author software, calculation peak time hemostasis potential spontaneous clots. Growth lysis fibrin clots were studied plasma purified from platelets. All preanalytic procedures...
To detect coagulability impairment of blood plasma in patients with schizophrenia or affective disease a state exacerbation using thrombodynamics test.The study included 46 women, 32 attack-like/shift-like/or continuous (ICD-10: F20.00, F20.01, F20.02), 7 schizotypal disorder F21.3-21.4) and F32.00, F32.3). Thrombodynamics tests were performed on T-2 analyzer ('Hemacore LLC', Moscow, Russia).For the first time, it was shown that patient population (n=46), thrombodynamic parameters clot...
Complement system is an important component of innate immunity, providing primary protection against pathogens invading the body. In addition, it was shown that complement associated with many diseases, not only autoimmune and infectious, but also mental disorders. this regard, necessary to develop affordable fast method measuring activity in real-time mode. We present a new semi-automated for assessment serum activity. The assay based on cytolytic action upon ciliate organism Tetrahymena...
To detect plasma procoagulant activity in patients with schizophrenia at admission to the hospital a state of exacerbation before (point 1) and after 2) pharmacotherapy evaluate platelet hemostasis abnormalities.The study included 80 women, aged from 16 57 years, median age 28 continuous, paroxysmal-progressive or paroxysmal course (F20.00, F20.01, F20.02 according ICD-10). In 42 patients, depressive disorders structure were observed. The thrombodynamic test (TD) was performed on T-2...
Introduction: currently, it is proved that the pathogenesis of schizophrenia associated with formation chronic foci aseptic inflammation (neuroinflammation) in brain patients. It also known neuroinflammation quickly turns into systemic inflammation. Permeability blood-brain barrier impaired. Proinflammatory cytokines and other inflammatory factors release blood. Systemic leads to activation all cells immune system blood platelets. Activation platelets accompanied by а generation a large...
OBJECTIVE To identify a possible correlation between parameters of thrombodynamic coagulation and negative syndromes in patients with schizophrenia. MATERIAL AND METHODS The study included 148 female inpatients, aged 16 to 57 years, the following mental disorders: schizophrenia attack-like/attack-progressive/continuous type course (F20.00-2), schizotypal disorder affective fluctuations (F21.3-4). thrombodynamics test (TD) was carried out on T-2 recorder (Hemacore LLC, Moscow, Russia)....
To show that the results of evaluation monocyte pro-inflammatory activity (PA) in patients with juvenile depression and healthy donors, obtained using a new method developed by us for counting relative number large monocytes on multifunctional counter cell analyzer, are similar to standard assessment level proinflammatory CD14+/CD16+ - flow cytofluorimeter.The PA monocytes, isolated from peripheral venous blood 18 12 mentally somatically age gender-matched persons was evaluated two ways:...
To study a correlation between the values of thrombodynamics parameters hypercoagulation measured by test and severity catatonia in children with infantile psychosis childhood autism (F84.02).Twenty-four patients (22 boys 2 girls) aged from 3 to 13 years, were studied. The was determined BFCRS. A thrombodynamic performed platelet-free plasma using analyzer T-2 Thrombodynamics Device (Hemacore LLC, Russia).Thrombodynamic (TD) clot growth rates activator (V, Vi Vst) statistically significantly...
S ummary The blood serum of schizophrenic patients differs from that normal people and with a number other mental diseases concerning its effect on glucose transformation chicken erythrocites in the experiments vitro causing an increase lactate/pyruvate coefficient. extent this is associated severity duration process. A biologically active factor responsible for described phenomenon instable, thermolabile, represents either substance protein nature or two‐component system consisting...
Objective To identify relationships between thrombodynamic values and the severity of condition in patients with schizophrenia spectrum disorders (SSD) before after treatment. Material methods The study included 92 an acute state or schizotypal disorder, aged 16 to 57 years (median age [Q1; Q3] - 25 years). All received complex psychopharmacotherapy adequate their psychopathological state. PANSS was used assess symptoms patients. coagulation parameters were determined by thrombodynamics...