A5101472493- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Pain Mechanisms and Treatments
- S100 Proteins and Annexins
- Neuroendocrine regulation and behavior
- Anesthesia and Neurotoxicity Research
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Ginkgo biloba and Cashew Applications
- Neurological Disease Mechanisms and Treatments
- Ion channel regulation and function
- Zebrafish Biomedical Research Applications
- Immune Response and Inflammation
- Neurotransmitter Receptor Influence on Behavior
- Botulinum Toxin and Related Neurological Disorders
- Neuropeptides and Animal Physiology
- Autophagy in Disease and Therapy
- Dementia and Cognitive Impairment Research
- Estrogen and related hormone effects
- Epigenetics and DNA Methylation
- Receptor Mechanisms and Signaling
- Sirtuins and Resveratrol in Medicine
National Taiwan Normal University
2014-2025
Emory University
2001-2002
National Cheng Kung University
1997-2001
Institute of Biomedical Sciences, Academia Sinica
1992
NMDA receptor antagonists block conditioned fear extinction when injected systemically and also infused directly into the amygdala. Here we evaluate ability of d -cycloserine (DCS), a partial agonist at strychnine-insensitive glycine-recognition site on complex, to facilitate after systemic administration or intra-amygdala infusions. Rats received 10 pairings 3.7 sec light 0.4 mA footshock (fear conditioning). Fear-potentiated startle (increased in presence vs absence light) was subsequently...
Previous results indicate that intra-amygdala infusions of NMDA receptor antagonists block the extinction conditioned fear. Mitogen-activated protein kinase (MAPK) can be activated by stimulation and is involved in excitatory fear conditioning. Here, we evaluate role MAPK within basolateral amygdala Rats received 10 light-shock pairings. After 24 hr, was assessed eliciting acoustic startle reflex presence stimulus (CS) (CS-noise trials) also its absence (noise-alone trials). subsequently an...
Resveratrol is a natural polyphenol and possesses many biological functions such as anti-inflammatory activity protection against atherosclerosis myocardial infraction. Parkinson's disease common progressive neurodegenerative disease. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) the most useful neurotoxin to induce Parkinsonism. The present study was carried out elucidate neuroprotective effect possible mechanism of resveratrol on MPTP-induced striatal neuron loss. Sixty adult Balb/c...
Interleukin-1 (IL-1) has many roles in the brain addition to mediating inflammatory processes glia, and also been implicated neurodegenerative disease. Traumatic injury (TBI) is one of most prevalent causes morbidity mortality young persons. We conducted a study assess effect IL-1 on TBI-induced death hippocampal neurons. After TBI was induced adult male Sprague-Dawley rats under anesthesia, we evaluated neuronal damage score through microscopic examination Pulsinelli's grading system....
Objective: Brain edema is one of the characteristic features patients with severe traumatic brain injury. The aim this study was to examine effects Na+-K+-2Cl− co-transporter on injury-induced and neuron damage elucidate relationship between mitogen-activated protein kinase (MAPK) cascade. Design: Laboratory investigation. Setting: University research laboratory. Subjects: Male Wistar rats weighing 350–400 g. Interventions: Anesthetized animals were subjected a weight-drop device (450-g...
Na+ -K+ -2Cl- co-transporter (NKCC1) plays an important role in traumatic brain injury (TBI)-induced edema via the MAPK cascade. The transient receptor potential vanilloid type 4 (TRPV4) channel participates neurogenic inflammation, pain transmission, and edema. In this study, we investigated relationship between NKCC1 TRPV4 related signaling pathways TBI-induced neuronal damage. TBI was induced by calibrated weight-drop device. Adult male Wistar rats were randomly assigned into sham...
Adult neurogenesis occurs in the subgranular zone of hippocampal dentate gyrus, and can be modulated by physiological pathological events. We examined effect vascular endothelial growth factor (VEGF), correlation between VEGF Raf/MEK/ERK cascade after traumatic brain injury (TBI). The expression phosphorylation level were analyzed Western blot, TBI-induced was determined immunofluorescence labeling confocal microscopic detection. Hippocampal began to increase 12 h, reached a peak at day 7....
Traumatic brain injury (TBI) is a major public health problem. Here, we developed novel model of non-invasive TBI induced by laser irradiation in the telencephalon adult zebrafish (Danio rerio) and assessed their behavior neuromorphology to validate evaluate potential targets for neuroreparative treatment. Overall, hypolocomotion anxiety-like tank test, strikingly recapitulating responses mammalian models, hence supporting face validity our model. NeuN-positive cell staining was markedly...
Fragile X syndrome (FXS) is a generally hereditary form of human mental retardation that caused by triplet repeat expansion (CGG) mutation in fragile 1 (fmr1) gene promoter and results the absence protein (FMRP) expression. The common symptoms FXS patients include learning disabilities, anxiety, autistic behaviors, as well other behavioral abnormalities. Our previous demonstrated abnormalities fmr1 knockout (KO) zebrafish such fear memory impairment autism-like behavior. Here, we studied...
Objective: To examine the effects of administration bumetanide, a specific NKCC1 inhibitor, on traumatic brain injury (TBI)-induced interleukin-1 (IL-1) expression. Methods: TBI model was induced by calibrated weight drop device (450 g in weight, 2.0 m height) adult rats based procedures previously reported. One hundred and sixty Wistar were divided into sham-control group experimental for time course works TBI. The expression IL-1β edema neuronal damage determined these animals after...
Recent studies have shown that opioid treatment can reduce pro-inflammatory cytokine production and counteract various neuropathic pain syndromes. Granulocyte colony-stimulating factor (G-CSF) promote immune cell differentiation by increasing leukocytes (mainly opioid-containing polymorphonuclear (PMN) cells), suggesting a potential beneficial role in treating chronic pain. This study shows the effectiveness of exogenous G-CSF (200 µg/kg) for alleviating thermal hyperalgesia mechanical...
Abstract Background Nogo-A is a member of the reticulon family membrane-associated proteins and plays an important role in axonal remodeling. The present study aimed to investigate alterations expression following traumatic brain injury (TBI)-induced inflammation neuronal damage. Methods A weight-drop device was used deliver standard impact rats. Western blot, RT-PCR ELISA were analyze IL-1β. antisense, irrelevant control oligonucleotide intracerebroventricularly infused. We also performed H...
Drugs in clinical use with indole structure exhibit side effects. Therefore, to search for compounds more efficacy and less effect cancer therapy, we developed a novel compound SK228 examined its effects mechanisms on antitumor growth invasion inhibition cell tumor xenografts nude mice models. significantly inhibited of different lung esophageal lines at sub-micromolar range, but not normal cells. induced DNA damages mainly by producing reactive oxygen species (ROS) resulting apoptosis....