A5102032710- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Sleep and Wakefulness Research
- Alzheimer's disease research and treatments
- EEG and Brain-Computer Interfaces
- Neurogenesis and neuroplasticity mechanisms
- Circadian rhythm and melatonin
- Neurological disorders and treatments
- Menstrual Health and Disorders
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Electromagnetic Fields and Biological Effects
- Diet and metabolism studies
- Neural dynamics and brain function
- Diet, Metabolism, and Disease
- Sleep and Work-Related Fatigue
- Gestational Diabetes Research and Management
- Seaweed-derived Bioactive Compounds
- Impact of Light on Environment and Health
- Healthcare Systems and Public Health
- Phytochemical and Pharmacological Studies
- Sleep and related disorders
- Machine Learning and Data Classification
- Non-Invasive Vital Sign Monitoring
- Phytochemical Studies and Bioactivities
Taipei City Hospital
2014-2023
National Chengchi University
2019-2021
Taipei Municipal YangMing Hospital
1993-2020
University of Wisconsin–Madison
2012-2013
Taipei Veterans General Hospital
2012
Loughborough University
2007
Prolonged wakefulness leads to a progressive increase in sleep pressure, reflected global slow wave activity (SWA, 0.5-4.5 Hz) the electroencephalogram (EEG). A wake theta (5-9 also occurs. Recently, it was shown that prolonged rodents signs of "local sleep" an otherwise awake brain, accompanied by slow/theta (2-6 local EEG occurs at different times cortical areas. Compelling evidence animals and humans indicates is locally regulated amount experience-dependent plasticity. Here, we asked...
The function of sleep in humans has been investigated using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging recordings to provide accurate scores with spatial precision. Recent studies have demonstrated that spontaneous brain oscillations connectivity dissociate during nonrapid eye movement (NREM) sleep; this leads cognitive processes, such as memory consolidation emotional modulation. However, variations network across the stages or between sleep/wake...
Dementia with Lewy bodies (DLB) is caused by accumulation of bodies, destruction mitochondria, and excess glutamate in synapses, which eventually leads to excitotoxicity, neurodegeneration, cognitive impairments. Ceftriaxone (CEF) reduces excitotoxicity increasing transporter 1 expression reuptake. We investigated whether CEF can prevent decline neurological deficits increase neurogenesis DLB rats. Male Wistar rats infused viral vector containing human alpha-synuclein (α-syn) gene, SNCA, the...
Dementia with Lewy bodies (DLB) is characterized by neuronal deficits and α-synuclein inclusions in the brain. Ceftriaxone (CEF), a β-lactam antibiotic, has been suggested as therapeutic agent several neurodegenerative disorders for its abilities to counteract glutamate-mediated toxicity block polymerization. By using manganese-enhanced magnetic resonance imaging (MEMRI) immunohistochemistry, we measured effects of CEF on activity accumulation brain DLB rat model. The data showed that...
New Findings What is the central question of this study? Imbalance activities between GABAergic and glutamatergic systems involved in epilepsy. It not known whether simultaneously increasing decreasing activity using valproic acid ceftriaxone, respectively, leads to better seizure control. Ceftriaxone suppressed cognitive deficits restored neuronal density number newborn cells hippocampus a rat model Combined treatment with ceftriaxone showed additive effects suppression. Abstract The...
Osteoporosis is a major disease associated with aging. We have previously demonstrated that diosgenin prevents osteoporosis in both menopause and D-galactose-induced aging rats. OXYS rats reveal an accelerated senescence are used as suitable model of osteoporosis. The aim the present study was to analyze microarchitecture morphological changes femur using tests microcomputed tomography scanning, evaluate effects oral administration at 10 50 mg/kg/day on result showed that, compared...
Epilepsy, which is caused by abnormal neuronal firing in the brain, a common neurological disease and affects motor cognitive functions. Excessive levels of glutamate insufficient inhibitory GABA are involved its pathophysiology. Valproic acid (Val), GABAergic agonist, one first-line antiepileptic drugs, but it shows many adverse side effects at clinical dose. Clavulanic (CA), β-lactamase inhibitor, has been demonstrated to increase transporter-1 expression. This study evaluated CA Val an...
Light can induce an alertness response in humans. The effects of exposure to bright light vs. dim on the levels during day, especially afternoon, as reported literature, are inconsistent. This study employed a multiple measurement strategy explore temporal variations regular office (1,200 lx 200 at eye level, 6,500 K) participants for 5 h afternoon. In this study, 20 healthy adults (11 female; mean age 23.25 ± 2.3 years) underwent Karolinska sleepiness scale (KSS), auditory psychomotor...
Biomedicine is a field rich in variety of heterogeneous, evolving, complex and unstructured massive data, coming from autonomous sources (i.e. HACE theorem). Big data mining has become the most fascinating fastest growing area which enables selection, exploring modeling vast amount medical to help clinical decision making, prevent medication error, enhance patients' outcomes. Given complexity nature biomedicine, it was acknowledged that there no single best method for all applications....
Recent EEG and fMRI studies showed that even just one night of sleeplessness tempers brain’s capacity to differentiate emotion neutrality. Dysmenorrheic women, who undertake recurrent menstrual pain stimulation, often show a higher sensitivity lower sleep quality throughout the menstruate cycle (Iacovides et al. 2009; Hung al., 2017). In view possible long-term effect loss on dysmenorrheic women’s cognitive control emotion, this study explored if women have proportion premenstrual symdromes...
Abstract Introduction Higher tumor necrosis factor-alpha (TNF-α) gene expression has been revealed in the peripheral blood monocytes across menstrual cycle patients with primary dysmenorrhea (PDM) than unaffected control. Sleep quality is affected by environmental factors, endocrine function abnormalities and genetic factors. The aim of this study was to evaluate effect TNF-α G308A polymorphism (rs1800629) on self-reported sleep, health, pain severity as well peri-ovulatory serum level women...
Abstract Introduction Although the relationships amongst sleep, pain and anxiety have been evidenced, underlying neurological mechanisms remain elusive. Primary dysmenorrhea is a good model of spontaneous with clear painful (menstruation, state) free (e.g., peri-ovulatory phase, trait) conditions. We sought to investigate state- trait-related neural signatures that link sleep in primary dysmenorrhea. Methods Thirty female subjects 30 healthy controls completed resting-state functional...