Abstract: Sleep disorders cause cognitive dysfunction in which impaired neuronal plasticity the hippocampus may underline molecular mechanisms of this deficiency. As sirtuin 1 (SIRT1) plays an important role maintaining metabolic homeostasis and plasticity, study is aimed to determine whether melatonin exerts beneficial effects on preserving SIRT1 activation following total sleep deprivation (TSD). TSD was performed by disc water method for five consecutive days. During period, animals daily...

In this study, five urethane acrylates (UAs), namely aliphatic hexa-acrylate (87A), aromatic (88A), UA (588), triacrylate diluted in 15% HDD (594), and high-functional (5812), were selected to formulate UA-based photopolymer resins for digital light processing (DLP)-based 3D printing. Each (40 wt%) was added blended homogenously with ethoxylated pentaerythritol tetraacrylate wt%), isobornyl acrylate (12 diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide (3 a pink acrylic (5 wt%). resin...

Abstract Periodontitis ( PD ) is an inflammatory disease characterized by gingival inflammation and resorption of alveolar bone. Impaired receptor activator nuclear factor‐kappa B ligand/osteoprotegerin RANKL / OPG signaling caused enhanced production pro‐inflammatory cytokines plays essential role in the pathogenesis . Considering melatonin possesses significant anti‐inflammatory property, this study aimed to determine whether prophylactic treatment with would effectively normalize...

Activation of proliferation Schwann cells is crucial for axonal guidance and successful nerve regeneration following peripheral injury (PNI). Considering melatonin plays an important role in proliferative regulation central glial cells, the present study determined whether can effectively promote cell improve after PNI. The spontaneous immortalized rat line (RSC 96 cells) was first analyzed by quantitative polymerase chain reaction (QPCR) to detect potential existence receptors....

The morphological peculiarities of receptor neurons and support cells in the olfactory epithelium male yellowfin sculpin (Cottocomephorus grewingkii; Dybowski, 1874) were studied during pre-spawning, spawning (when males do not feed have a higher sensitivity to female pheromones), guarding (the fertilized eggs) periods. This study was performed using electron transmission laser confocal microscopy. Structural changes fish are associated with shift signals from alimentary pheromonal. These...

Sleep disorders are associated with an increased rate of various metabolic disturbances, which may be related to oxidative stress and consequent lipid peroxidation. Since hepatic phosphatidylcholine plays important role in regulation, the aim present study was determine expression liver following total sleep deprivation. To effects deprivation, we used adult rats implanted for polygraphic recording. Phosphatidylcholine examined molecularly by use time-of-flight secondary ion mass...

Abstract: Acute bacterial meningitis caused by Klebsiella pneumoniae ( K. ) is a major health threat with high mortality rate and severe neuro‐cognitive sequelae. The intense pro‐inflammatory cytokine released from calcium‐mediated microglial activation plays an important role in eliciting neuronal damage the hippocampal region. Considering melatonin possesses anti‐inflammatory immuno‐modulatory properties, present study determined whether can effectively decrease inflammatory responses...

Abstract Prolonged exposure to gamma‐hydroxybutyric acid ( GHB ) would cause drug intoxication in which impaired cognitive function results from enhanced hippocampal oxidative stress may serve as a major symptom this deficiency. Considering melatonin possesses significant anti‐oxidative efficacy, study aimed determine whether successfully promote the nuclear factor erythroid 2‐related 2 and antioxidant responsive element (Nrf2‐ ARE signaling, depress stress, rescue bioenergetics following...

Abstract: Peripheral nerve injury (PNI) produces functional changes in lesioned neurons which oxidative stress is considered to be the main cause of neuronal damage. As superoxide dismutase (SOD) an important antioxidative enzyme involved redox regulation stress, present study determined whether melatonin would exert its beneficial effects by preserving SOD reactivity following PNI. Adult rats subjected hypoglossal transection were intraperitoneally injected with at ones for 3, 7, 14, 30 and...

Excessive production of nitric oxide (NO) may play a detrimental role in the process hypoxia‐related neuropathology. This study explored whether treatment with melatonin would attenuate neuropathological changes vagal ganglia following severe hypoxic insult. Thirty minutes prior to hypoxia treatment, young adult rats were pre‐treated at 5, 25 or 100 mg/kg injected intraperitoneally. Hypoxia was achieved by subjecting barometric pressure 0.2 atm ( P O 2 =43 Torr) for 4 hr an altitude chamber....

Abstract Sleep disorders are a form of stress associated with increased sympathetic activity, and they risk factor for the occurrence cardiovascular disease. Given that nitric oxide (NO) may play an inhibitory role in regulation tone, this study set out to determine NO synthase (NOS) reactivity primary afferent neurons (i.e. nodose neurons) following total sleep deprivation (TSD). TSD was performed by disc‐on‐water method. Following 5 days TSD, all experimental animals were investigated...

Porphyromonas gingivalis (P. gingivalis), a major periodontal pathogen, causes intrauterine infection/inflammation. Offspring exposed to infection/inflammation have an increased risk of neurological disorders, regardless gestational age. However, the relationship between maternal periodontitis and offspring functional/histological changes in brain has not yet been elucidated.In this study, we used mouse model investigate effects odontogenic infection P. on behavior tissue.The step-through...

This study aimed to elucidate whether melatonin would exert beneficial effects on the neuronal functions of nodose ganglion (NG) following acute hypoxic insult. The cytochrome oxidase (COX) and nicotinamine adenine dinucleotide phosphate diaphorase (NADPH-d) histochemistry along with nitric oxide synthase (NOS) immunofluorescence were used examine metabolic stage production in neurons respectively. Adult rats injected intraperitoneally at 5 or 100 mg/kg. Hypoxia was achieved by placing into...

Previous studies have shown that the plateau modulus Gp of wormlike micelles formed in water driven by hydrophobic interactions is a constant upon heating, similar to polymer solutions, and reverse worms oils hydrogen bonding decreases with increasing temperature. In this work, we investigated induced three chloride salts bind lecithin through different strengths electrostatic interactions, order LaCl3 > CaCl2 LiCl. We correlated interaction temperature-dependent rheological properties found...

Abstract Hsu, CC, Fong, TH, Chang, HM, Su, B, Chi, CP, Kan, NW, and MC. Low second-to-fourth digit ratio has high explosive power? A prepubertal study. J Strength Cond Res 32(7): 2091–2095, 2018—A recent study reported that lower limb power had no correlation with the index finger: ring finger (2D:4D) ratio. However, many studies hypothesized a 2D:4D (reflecting relative higher testosterone exposure) predicts physical fitness. The aim of this was to replicate in sample Taiwanese children....

Early-life sleep deprivation (ESD) is a serious condition with severe cognitive sequelae. Considering hippocampus plays an essential role in regulation, the present study aims to determine whether melatonin, neuroendocrine beard significant anti-oxidative activity, would greatly depress hippocampal oxidative stress, improves molecular machinery, and consequently exerts neuro-protective effects following ESD. Male weanling Wistar rats (postnatal day 21) were subjected ESD for three weeks....

The role of the hepato-protective agent plasmon-activated water (PAW) as an innovative anti-oxidant during chronic sleep deprivation (SD) is realized in this study. PAW possesses reduced hydrogen-bonded structure, higher chemical potential and significant anti-oxidative properties. In vitro tests using rat liver cell line (Clone-9) have demonstrated that non-cytotoxic does not change cellular migration capacity. vivo experiment on SD rats suffering from intense oxidative damage to liver,...