The main objective of this study was to evaluate the efficacy and safety Lactobacillus rhamnosus in children aged 4-48 months with atopic dermatitis.The design a two-center, double-blind, randomized, placebo-controlled two parallel groups profile L. dermatitis diagnosed using Hanifin Rajka criteria Scoring Atopic Dermatitis (SCORAD) ≥ 15 at enrollment. duration 8 weeks total five visits. enrolled patients were allocated into either treatment group (one ComProbi capsule containing day) or...

Early diagnosis and initiation of hypothermia therapy for neonatal hypoxic-ischemic encephalopathy (HIE) are critical within the first 6 h after birth. Collecting urine, especially from neonates with HIE, can be challenging time-consuming post-birth due to likelihood renal injury. We assessed whether urine protein levels, measured via a simple urinalysis on day, could correlate outcomes HIE. conducted analyses patients HIE day establish correlation between severity neurodevelopmental at ≥1...

Background: Cordyceps militaris is a well-known fungus with immunomodulatory activity.It generally used in traditional Chinese medicine to treat hemoptysis, bronchial or lung inflammation, and urogenital disorders.The purpose of our study was evaluate the effect cultivated C. on airway inflammation mouse asthma model.Methods: BALB/c mice were sensitized intraperitoneal ovalbumin (OVA) Days 0 14, then given intranasal OVA Day 14 25-27.Randomized treatment groups administered militaris,...

Abstract: Acute bacterial meningitis caused by Klebsiella pneumoniae ( K. ) is a major health threat with high mortality rate and severe neuro‐cognitive sequelae. The intense pro‐inflammatory cytokine released from calcium‐mediated microglial activation plays an important role in eliciting neuronal damage the hippocampal region. Considering melatonin possesses anti‐inflammatory immuno‐modulatory properties, present study determined whether can effectively decrease inflammatory responses...

Abstract Background: The association between neonatal jaundice and childhood asthma is a new finding of two reports. purpose the study was to verify their results. Methods: Data from 11,321 children were collected National Health Insurance Research Database. Their claims data evaluated birth 10 yr old. Children analyzed as case (those with jaundice) controls without jaundice). diagnostic criteria for follows: at least four diagnoses outpatient services emergency department (ED), or one...

Background A nationwide asthma survey on the effects of air pollution is lacking in Taiwan. The purpose this study was to evaluate time trend and relationship between health care services for Methods Health ambient data were obtained from National Insurance Research database Environmental Protection Administration 2000 through 2009, respectively. services, including those related outpatient inpatient visits compared according concentration pollutants. Results number asthma-patient...

Rotavirus and norovirus are the most common known causes of viral gastroenteritis in children. This study examined association between serum interleukin 6 (IL-6) 8 (IL-8) levels disease severity acute phase rotavirus children, it also explored role fecal cytokine children with bacterial gastroenteritis.This prospective enrolled patients aged 4 months to 14 years admitted a tertiary care center. Peripheral blood samples were collected for IL-6 IL-8 assays within first 3 days diarrhea. Stool...

Background: Interleukin (IL)-8 acts as a potent neutrophils chemoattractant responsible for the migration of into infected renal tissue to protect against invading pathogens. The aim this study was assess role IL-8 on acute-phase pyelonephritis and later scarring in children. Patients Methods: A total 124 children with first-time febrile urinary tract infection (UTI) were studied. diagnosis acute confirmed by 99mTc-dimercaptosuccinic acid (DMSA) scan. Serum urine samples obtained from UTI 20...

BackgroundThis study was designed to examine the capability of renal ultrasonography (US) for predicting vesicoureteral reflux (VUR) and scarring (RS), assess, using initial US, significant urologic abnormalities that impact on management children hospitalized with a first febrile urinary tract infection (UTI).MethodsHospitalized aged ≤ 2 years UTI were prospectively evaluated imaging studies, including 99mTc dimercaptosuccinic acid (DMSA) scan, voiding cystourethrography.ResultsOf 310...

Steroid-insensitive asthma-related airway inflammation is associated with the expression of epidermal growth factor receptor (EGFR) tyrosine kinase in asthmatic bronchial epithelium. Proinflammatory cytokines IL-6 and IL-8 are related to steroid-insensitive asthma. It currently unknown how EGFR-tyrosine inhibitors (EGFR-TKIs) affects house dust mite (HDM)-induced asthma terms inflammatory steroid-resistant further signaling pathway. Cytokine expressions EGFR pathway were performed by ELISA,...

Acute pyelonephritis is a common infectious disease in children and can result permanent renal damage. Interleukin-6 (IL-6) an important mediator of inflammation response to bacterial infection. This study investigated the potential relationship between acute-phase IL-6 subsequent scarring with first time febrile acute pyelonephritis.In total, 79 (age range 1-120 months) urinary tract infection (UTI) were included. The diagnosis was confirmed by (99m)Tc-dimercaptosuccinic acid (DMSA) scan....

There is growing evidence of positive correlations between asthma (AS) and obesity in adults children. Leptin an gene product secreted by white adipose tissue; elevated serum levels are found obese Recently, leptin has also been to be associated with allergic rhinitis (AR). However, the links leptin, atopic AS, AR remained undetermined. Because AS share common inflammatory mechanisms, our aim was determine if there were any differences asthmatic children nonasthmatic AR.We studied 114 (67...

Cite this as : M.‐S. Ku, H.‐L. Sun, K.‐H. Lu, J.‐N. Sheu, H.‐S. Lee, S.‐F. Yang and Lue, Clinical & Experimental Allergy , 2011 (41) 794–800. Summary Background Although asthma allergic rhinitis (AR) are considered to be one syndrome, many questions remain unanswered. Why do some AR patients develop but others not, which factors play a role in the development of that have so far not been clearly elucidated. Objective We hypothesize children with who Clara cell secretory protein ( CC16,...

Leigh syndrome is an early-onset progressive neurodegenerative disorder with a characteristic neuropathology consisting of focal, bilateral lesions in one or more areas the central nervous system. The brain images are characterized by markedly symmetrical involvement, most frequently putamen. We report 2-year-old girl manifested as acute onset altered level consciousness. Brain magnetic resonance showed abnormal signal intensity over basal ganglia and cerebellar dentate nuclei. Despite...