Background: Cordyceps militaris is a well-known fungus with immunomodulatory activity.It generally used in traditional Chinese medicine to treat hemoptysis, bronchial or lung inflammation, and urogenital disorders.The purpose of our study was evaluate the effect cultivated C. on airway inflammation mouse asthma model.Methods: BALB/c mice were sensitized intraperitoneal ovalbumin (OVA) Days 0 14, then given intranasal OVA Day 14 25-27.Randomized treatment groups administered militaris,...

Abstract Background: The association between neonatal jaundice and childhood asthma is a new finding of two reports. purpose the study was to verify their results. Methods: Data from 11,321 children were collected National Health Insurance Research Database. Their claims data evaluated birth 10 yr old. Children analyzed as case (those with jaundice) controls without jaundice). diagnostic criteria for follows: at least four diagnoses outpatient services emergency department (ED), or one...

Background A nationwide asthma survey on the effects of air pollution is lacking in Taiwan. The purpose this study was to evaluate time trend and relationship between health care services for Methods Health ambient data were obtained from National Insurance Research database Environmental Protection Administration 2000 through 2009, respectively. services, including those related outpatient inpatient visits compared according concentration pollutants. Results number asthma-patient...

House dust mite (HDM) is well known as one of the major indoor allergens that trigger allergic inflammation, especially asthma, and accounts for 85% all cases. So far, asthma has been thought a condition imbalance between T helper (Th)1 Th2. Fungal immunomodulatory protein-Flammulina velutipes (FIP-fve) seemingly demonstrated to modulate response Th1 cytokine production. The aim this study was investigate if oral administration FIP-fve can inhibit HDM-induced inflammation in mouse model. We...

Cetirizine (Zyrtec) is a potent and long‐acting second‐generation histamine H1‐ receptor antagonist for the treatment of allergic disease, such as rhinitis chronic idiopathic urticaria, in adult child. It racemic mixture levocetirizine (Xyzal) dextrocetirizine. The purpose this present study was to compare efficacy cetirizine, placebo pediatric perennial rhinitis. 74 patients, aged 6 12 years old, assigned 1 3 groups weeks randomly. effects three agents were compared with Pediatric...

Asthma is a heterogeneous inflammatory disorder of the airway. A Th2 response usually contributes to high levels allergen-specific IgE and eosinophilic airway inflammation. Several findings have demonstrated that neutrophils, not eosinophils, are major cells in chronic asthma patients with steroid-resistance. Lactobacillus rhammosus GG (LGG) exhibits anti-inflammatory properties on OVA-induced acute We hypothesized orally administrated LGG should reduce remodeling experimental models. Female...

The association between air pollution, allergic rhinitis (AR), and obesity has not been studied. From 2007 to 2011, 52 obese 152 non-obese children (7-17 years old) with AR were recruited. Pediatric-Rhinoconjunctivitis-Quality-of-Life Questionnaire (PRQLQ) nasal peak expiratory flow (NPEF) tested. Association the scores rates of two tests mean pollutant concentrations within 7 days before compared. When exposed higher CO, PM10, PM2.5, worse discomfort 39.4%, 44.4% 39.3% in children; 18.0%,...

There is growing evidence of positive correlations between asthma (AS) and obesity in adults children. Leptin an gene product secreted by white adipose tissue; elevated serum levels are found obese Recently, leptin has also been to be associated with allergic rhinitis (AR). However, the links leptin, atopic AS, AR remained undetermined. Because AS share common inflammatory mechanisms, our aim was determine if there were any differences asthmatic children nonasthmatic AR.We studied 114 (67...

The atopic march hypothesis suggests that allergy diseases often progress from dermatitis to allergic asthma, and rhinitis. How can the classic progression of be observed in pediatric patient population? This study aimed observe pattern progression, onset age, disease intervals, frequency march. Data National Health Insurance Research Database period 1996-2008 were used obtain a cohort children with disease. Physician's diagnosis was confirm based on international coding. age compared. There...

Abstract Background As children represent the future, ensuring that they receive proper health care should be a primary concern of our societies. Epidemiological research underpins importance effective child strategies, and highlights need for accurate data collection; such surveys are currently lacking in Taiwan. In descriptive studies, we compared differences ten most common diseases year 2000 2009 among Taiwanese children. Methods Data total 174,651 142,200 visits under eighteen years old...

Objectives The association between AS (asthma) and dental caries is controversial, while that allergic rhinitis (AR) has not been established. This study aimed to verify the relationship among AR, caries. Design Retrospective cohort study. Setting Data from Health Insurance Database of Taiwan's National Research Database. Participants Nine thousand thirty‐eight children born in 2004 were obtained. Their claims data evaluated birth age 9 years. Main outcome measures frequencies clinical...

Background This study evaluates the association between neonatal jaundice and childhood allergic rhinitis (AR). Methods Eleven thousand three hundred twenty-eight children were collected from National Health Insurance Research Database in Taiwan. Their claims data evaluated birth to 10 years of age, they assigned either (with jaundice) or control (without group. The diagnostic criteria for AR at least diagnoses outpatient services, one diagnosis during an admission, emergency department....

Although allergic asthma and rhinitis have recently been considered to be a single disease, many questions remain unanswered. Why do some atopic patients develop symptoms others symptoms? Which factors play role in the development of different phenotypes? We hypothesized that angiotensin-converting enzyme (ACE) gene polymorphism might phenotypes children with rhinitis. The study sample included 106 rhinitis, but no asthma, 105 age- gender-matched asthma. Subjects both groups exhibited same...

Background The association between asthma (AS), allergic rhinitis (AR) and oral diseases remains inconclusive in adults. AS AR often coexist. However, studies that investigate AS, together their with are scarce. Methods Data from 22,898 men 28,541 women, aged 21 to 25 years, were collected a national database Taiwan. Five common diseases: dental caries, periodontitis, pulpitis, gingivitis, stomatitis/aphthae studied. Differences the incidence of five vs. non-AR, non-AS groups compared. men/...

Airborne fine particulate matter (PM2.5) in air pollution has become a significant global public health concern related to allergic diseases. Previous research indicates that PM2.5 not only affects the respiratory system but may also induce systemic inflammation various tissues. Moreover, its impact vary among different populations, with potential consequences during pregnancy and newborns. However, precise mechanisms through which induces inflammatory reactions remain unclear. This study...

Preventing the development of allergic skin disease in children is best way to treat disease.Ultraviolet (UV)-free blue light phototherapy has been reported atopic eczema. We evaluated effect neonatal on children.We randomly recruited 117,041 from an insurance research database. Those with jaundice and receiving were classified as icteric-phototherapy group (n = 4,744), those not icteric-non-phototherapy 5,003), without non-icteric 107,294). reviewed claims birth age 5 years. The prevalence...