A5102334981- Malaria Research and Control
- Viral-associated cancers and disorders
- HIV Research and Treatment
- Urban Transport and Accessibility
- T-cell and B-cell Immunology
- Digital Marketing and Social Media
- Technology Adoption and User Behaviour
- Immune Cell Function and Interaction
- Physical Activity and Health
- Diverse Aspects of Tourism Research
- Recreation, Leisure, Wilderness Management
- Gene expression and cancer classification
- NF-κB Signaling Pathways
- Herpesvirus Infections and Treatments
- Ear and Head Tumors
- Economic and Environmental Valuation
- RNA Research and Splicing
- Environmental Sustainability in Business
- Obesity, Physical Activity, Diet
- interferon and immune responses
- Angiogenesis and VEGF in Cancer
- Sharing Economy and Platforms
- Pharmacological Effects of Natural Compounds
- Phosphorus and nutrient management
- Algorithms and Data Compression
National Taiwan Normal University
2016-2025
National Taiwan University
2024-2025
National Kaohsiung University of Science and Technology
2024
Janssen (United States)
2024
University of Science and Technology
2024
National Taiwan University Hospital
2023
Keelung Chang Gung Memorial Hospital
2022-2023
The Tavistock and Portman NHS Foundation Trust
2022
Ensemble Therapeutics (United States)
2022
Royal College of Psychiatrists
2022
Infection of interleukin-10 (IL-10)-nonexpressing (IL-10(-/-)) mice with Plasmodium chabaudi (AS) leads to exacerbated pathology in female and death a proportion them. Hypoglycemia, hypothermia, loss body weight were significantly greater IL-10(-/-) than male knockout all wild-type (WT) during the acute phase infection. At this time, both produced more gamma interferon (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), IL-12p40 mRNA their respective WT counterparts. Inactivation IFN-gamma...
B cell knockout mice are unable to clear a primary erythrocytic infection of Plasmodium chabaudi . However, the early acute is controlled some extent, giving rise chronic relapsing parasitemia that can be reduced either by drug treatment or adoptive transfer cells. Similar rendered B-cell deficient lifelong with anti-μ antibodies, (μMT) retain predominant CD4 + Th1-like response malarial antigens throughout infection. This contrasts seen in control C57BL/6 which T-cell has switched...
ABSTRACT Interleukin-10 (IL-10)-deficient (IL-10 −/− ) mice infected with Plasmodium chabaudi (AS) suffer a more severe disease and exhibit higher rate of mortality than control C57BL/6 mice. Here, we show that drop in body temperature to below 28°C pronounced hypoglycemia 3 mM are reliable indicators lethal infection. Elevated inflammatory responses have been shown accompany pathology IL-10 We neutralization tumor necrosis factor alpha (TNF-α) abolishes ameliorates the hypothermia, weight...
P38α is a protein kinase that regulates the expression of inflammatory cytokines, suggesting role in pathogenesis diseases such as rheumatoid arthritis (RA) or systemic lupus erythematosus. Here, we describe preclinical pharmacology pamapimod, novel p38 mitogen-activated inhibitor. Pamapimod inhibited p38α and p38β enzymatic activity, with IC<sub>50</sub> values 0.014 ± 0.002 0.48 0.04 μM, respectively. There was no activity against p38δ p38γ isoforms. When profiled across 350 kinases,...
The purpose of the study is to identify a set key indicators with weightings for health tourism destinations by using an advanced analytic hierarchy process (AHP) method, derived from official, academic, and professional opinions experts. AHP method allocated evaluation criteria selected fifteen After expert evaluations were conducted, three dimensions eleven sub-dimensions initial destination obtained as follows: (1) special demands indications—medical care, promotion, leisure; (2) natural...
Polymorphisms in the CCR2 gene (CCR2-64I) and CCR5 promoter (pCCR5-59029G) have been correlated with slower HIV-1 disease progression. How these polymorphisms influence rate of AIDS progression has remained unclear. We therefore investigated whether nucleotide will reduce expression levels surface CXCR4, thus lead to For this, a cohort Chinese volunteers Taiwan was subjected determination pCCR5 genotypes followed by analysis CXCR4 on five cell types derived from peripheral blood mononuclear...
During a Plasmodium chabaudi infection in interleukin-10 (IL-10) knockout mice, there is greater parasite sequestration, more severe cerebral edema, and high frequency of hemorrhage compared with C57BL/6 mice. Anti-tumor necrosis factor alpha treatment ameliorated both edema hemorrhages, suggesting that proinflammatory responses contributed to complications infected IL-10(-/-)
The structural genes for the large and small subunits of Desulfovibrio gigas periplasmic [NiFe]hydrogenase were identified isolated by immunological oligonucleotide screening. gene subunit codes a 266-amino-acid, 28,724-dalton polypeptide which is separated 63 nucleotides from that 560-amino-acid, 61,707-dalton polypeptide. A putative signal peptide precedes coding region, may direct transport enzyme into compartment. Comparison amino acid sequence this with those two other classes...
This study investigates the influence of consumers’ alignment with Sustainable Development Goals (SDGs) on their participation in agricultural product subscription services. A two-step cluster analysis was employed to classify consumer behaviors into distinct groups, followed by discriminant and one-way ANOVA examine differences behavior SDG across these clusters. The findings identified three key subscriber categories: General, Price-Oriented, Quality-Oriented Subscribers. critical factor...
A review of the global history tourism development reveals a strong connection between government involvement and growth industry. In China, authorities are increasingly emphasizing role service websites in advancing digital governance within sector. Drawing on theories public administration, resource dependence, regional innovation systems, this study constructs an analytical framework to investigate influencing mechanisms development. Using data from 31 Chinese provinces, systematically...
Previously we described a system whereby human peripheral blood T cells stimulated for 8 days in cytokine cocktail acquired effector function contact-dependent induction of proinflammatory cytokines from monocytes. We termed these cytokine-activated (Tck) and found that the signalling pathways elicited responding monocytes were identical whether they placed contact with Tck or isolated rheumatoid arthritis (RA) synovial tissue. Here, using magnetic beads fluorescence-activated cell sorting,...
Epstein‐Barr virus is known to cause nasopharyngeal carcinoma. Although oral cavity located close the nasal pharynx, pathogenetic role of (EBV) in cancers unclear. This molecular epidemiology study uses EBV genomic microarray (EBV‐chip) simultaneously detect prevalent rate and viral gene expression patterns 57 squamous cell carcinoma biopsies (OSCC) collected from patients Taiwan. The majority specimens (82.5%) were EBV‐positive that probably expressed coincidently genes for EBNAs, LMP2A 2B,...
dTMP kinase (E.C.2.7.4.9.) catalyzes the phosphorylation of to corresponding diphosphate. This enzyme is essential for DNA synthesis in vivo and an important intermediate pathway many pyrimidine analog drugs. In this report, we describe isolation human gene by functional complementation a Saccharomyces cerevisiae cell cycle mutant, cdc8. The cDNA sequence revealed open reading frame that encodes protein with molecular weight 23,806. deduced was compared known sequences from different...
The 19 kDa C-terminal fragment of the malaria parasite merozoite surface protein 1 (MSP1(19)) is a leading vaccine candidate. In rodents, high antibody levels to this confer protective immunity, and can be generated by immunization with antigen in adjuvants. natural human infections, however, MSP1(19)-specific responses short-lived comparatively low, despite repeated exposure infection. tightly folded structure MSP1(19) stabilized five or six disulfide bonds. These bonds impede processing...
Maintaining physical activity is necessary to promote health in our daily lives. The Ecological Model of Active Living was proposed examine whether individuals participate active living. purpose this study understand the determinants and create a predictive path model intrapersonal, perceived environment, behavior settings, policy environment domains. Data were obtained from open government data questionnaires, including International Physical Activity Questionnaire, Health Belief Inventory,...
The Chinese medicinal herbs Radix Isatidis and Viola yedoensis Makino have been suggested to possess antiviral activity. This study tests whether these other Western herbal formulas can modulate the immune functions involving virus-suppression in BALB/c mouse. We first confirmed extract from Makino, but not Isatidis, traditional medicine (TCM) formula Chui-Uren-Chien (CUC), or a homeopathic drink Método Canova, could inhibit replications of herpes simplex virus-1 enterovirus 71 human...
Abstract Previously, we demonstrated that spontaneous TNF-α production by macrophages in rheumatoid arthritis (RA) synovial tissue is largely driven contact-dependent activation with T cells tissue. Whereas abundant IL-10 present these RA cultures, it does not adequately control the of TNF-α. In this study, have compared mechanisms involved IL-10–mediated regulation LPS-stimulated stimulated activated cells. We confirm 3′ enhancer region tnf essential for transcription, and its dominated a...