A5041289344- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Polyamine Metabolism and Applications
- T-cell and B-cell Immunology
- Parvovirus B19 Infection Studies
- Blood properties and coagulation
- Systemic Sclerosis and Related Diseases
- Monoclonal and Polyclonal Antibodies Research
- Phagocytosis and Immune Regulation
- Erythrocyte Function and Pathophysiology
- Dermatological and COVID-19 studies
- Amino Acid Enzymes and Metabolism
- Cell Adhesion Molecules Research
- Salivary Gland Disorders and Functions
- Gout, Hyperuricemia, Uric Acid
- Blood groups and transfusion
- Bone Metabolism and Diseases
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Hepatitis C virus research
- Pancreatitis Pathology and Treatment
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- Polyomavirus and related diseases
China Medical University
2015-2024
China Medical University Hospital
2015-2024
China Medical University
2023-2024
National Yang Ming Chiao Tung University
2015-2022
Chung Shan Medical University
2007-2016
National Health Research Institutes
2015
Chung Shan Medical University Hospital
2004-2014
Taipei Institute of Pathology
2014
Czech Academy of Sciences, Institute of Microbiology
2013
Institute of Immunology
2002-2007
Abstract The coronavirus SARS-CoV-2 is the causative agent of ongoing severe acute respiratory disease pandemic COVID-19. Tissue and cellular tropism one key to understanding pathogenesis SARS-CoV-2. We investigate expression subcellular localization receptor, angiotensin-converting enzyme 2 (ACE2), within upper (nasal) lower (pulmonary) tracts human donors using a diverse panel banked tissues. Here, we report our discovery that ACE2 receptor protein robustly localizes motile cilia airway...
6-Gingerol, a natural component of ginger, has been widely reported to possess antiinflammatory and antitumorigenic activities. Despite its potential efficacy against cancer, the anti-tumor mechanisms 6-gingerol are complicated remain sketchy. In present study, we aimed investigate effects on colon cancer cells. Our results revealed that treatment significantly reduced cell viability human cell, LoVo, in dose-dependent manner. Further flow cytometric analysis showed induced significant G2/M...
Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that catalyzes Ca(2+)-dependent protein modifications. In addition to being enzyme, TG2 also serves as a G for several seven transmembrane receptors and acts co-receptor integrin β1 β3 integrins distinguishing it from other members of the transglutaminase family. ubiquitously expressed in almost all cell types compartments, present on surface gets secreted extracellular matrix via non-classical mechanisms. has been...
Serum samples from 94 patients with systemic lupus erythematosus (SLE) a medical unit in Singapore were analysed for autoantibodies of 10 different specificities. The prevalence antibodies to the following antigens was as follows: double stranded (ds) DNA (43%), histone (81%), Sm (26%), nuclear ribonuclear protein (nRNP) (32%), SS-A(Ro) (63%), SS-B(La) (12%), SL/Ki (9%), ribosomal RNP (rRNP) (16%), p70/p80 (5%), proliferating cell antigen (PCNA) (3%). Except higher anti-SS-A(Ro), other...
Objective. To examine (1) the risk of death from cardiovascular disease (CVD) and all causes in patients with gout who do not undergo urate-lowering therapy (ULT), (2) effect ULT on mortality gout. Methods. In this prospective case-matched cohort study, 40,623 Taiwanese individuals aged ≥ 17 years were followed for 6.5 years. Mortality rate was compared between 1189 did receive reference subjects (no gout, no ULT) matched age, sex, index date diagnosis (1:3 gout/reference subjects), 764...
Background/Aim: The programmed death 1 (PD-1) receptor and its ligand (PD-L1) play pivotal roles in regulating host immune responses. However, the inhibitory effects of this pathway on function tumor infiltrating T lymphocytes gastric adenocarcinoma patients are not well-defined. Materials Methods: We characterized expression PD-1 PD-L1 peripheral blood cells analyzed association between PD-1/PD-L1 disease progression a cohort 60 with Helicobacter pylori infection, including 18...
Methods. Sera from 72 patients with systemic lupus erythematosus (SLE), 23 rheumatoid arthritis (RA), 18 Sjögren's syndrome (SS), eight Raynaud's phenomenon (RP), five primary biliary cirrhosis (PBC), polymyositis (PM), four erythema infectiosum (EI) and 22 normal controls were examined for parvovirus B19 (B19) infection by serological assays, nested PCR Southern blotting.
Objectives An increased risk of mortality in patients with hyperuricemia has been reported. We examined (1) the all-cause and cardiovascular disease (CVD) untreated hyperuricemic who did not receive urate-lowering therapy (ULT), (2) impact ULT on hyperuricemia. Methods In this retrospective case-matched cohort study during a mean follow-up 6.4 years, 40,118 Taiwanese individuals aged ≥17 years had never used gout were examined. The rate was compared between 3,088 reference subjects (no...
Gastric cancer is one of the most common malignant cancers with a poor prognosis and high mortality rate worldwide. Current treatment gastric includes surgery chemotherapy as main modalities, but potentially severe side-effects present considerable challenge. Gallic acid trihydroxybenzoic found to exert an anticancer effect against variety cells. The purpose this study was determine anti-cancer activity Galla chinensis its component gallic on human adenocarcinoma cells.MTT assay cell death...
We investigated the expression and subcellular localization of SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within upper (nasal) lower (pulmonary) respiratory tracts healthy human donors. detected ACE2 protein cilia organelle ciliated airway epithelial cells, which likely represents initial or early site viral entry during transmission. further determined whether in cells was influenced by patient demographics, clinical characteristics, co-morbidities, medication use, found...
Hepatitis C virus (HCV) infection has been found to be strikingly associated with autoimmune phenomena. The aim of the present study was investigate presence various autoantibodies in patients HCV infection. Anti-neutrophil cytoplamic antibody (ANCA), anti-dihydrolipoamide dehydrogenase (anti-E3), rheumatoid factor (RF), acetyltransferase (anti-E2), anti-SS-A/Ro (60 kD), (52 anti-SS-B/La, anti-topoisomerase II (anti-topo II), anti-cardiolipin (aCL), anti-dsDNA, anti-ssDNA, anti-nuclear...
Human parvovirus B19 has been found in various tissues addition to erythroid lineage cells, and non-structural protein (NS1) is reported induce cytotoxicity apoptosis but the mechanism non-permissive cells still unclear. To address this issue, we have constructed NS1 gene a cytomegalovirus episomal vector, pEGFP-C1 transfected it into monkey epithelial COS-7. EGFP-NS1 expression was monitored assessed by fluorescence microscopy, RT-PCR Western blot. The flow cytometric analysis showed that...
SUMMARY: Aim: Acute pyelonephritis is a common infectious disease in children and can result permanent renal damage. Interleukin (IL)‐1β an important inflammatory mediator that appears early during bacterial infection. This prospective study examined urine IL‐1β levels with acute documented by 99m Tc‐dimercaptosuccinic acid (DMSA) scan, also evaluated whether this cytokine correlated scarring. Methods: A total of 75 aged 1–121 months diagnosis first‐time febrile urinary tract infection (UTI)...