A5103108016- Medical and Biological Sciences
- Nasal Surgery and Airway Studies
- Sinusitis and nasal conditions
- Respiratory viral infections research
- Autophagy in Disease and Therapy
- Photodynamic Therapy Research Studies
- Dental Implant Techniques and Outcomes
- Long-Term Effects of COVID-19
- RNA Interference and Gene Delivery
- Photoacoustic and Ultrasonic Imaging
- Healthcare and Environmental Waste Management
- Animal Disease Management and Epidemiology
- Photochromic and Fluorescence Chemistry
- Nanoplatforms for cancer theranostics
- Virus-based gene therapy research
- Advanced Biosensing Techniques and Applications
- COVID-19 and healthcare impacts
- Nanoparticle-Based Drug Delivery
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Head and Neck Surgical Oncology
- COVID-19 Clinical Research Studies
- Polyamine Metabolism and Applications
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
National Taiwan University Hospital
2016-2024
National Taiwan University
2013-2015
We investigated the expression and subcellular localization of SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within upper (nasal) lower (pulmonary) respiratory tracts healthy human donors. detected ACE2 protein cilia organelle ciliated airway epithelial cells, which likely represents initial or early site viral entry during transmission. further determined whether in cells was influenced by patient demographics, clinical characteristics, co-morbidities, medication use, found...
To elucidate the interaction between hypoxia-induced autophagy and glycolysis in nasal polyp fibroblasts, regulatory role of Sirtuin 6 (SIRT6) pathogenesis polyp.Through examining expressions lactate dehydrogenase (LDH), microtubule-associated protein II light chain 3 (LC3II) (an marker), production under hypoxia, was investigated. The SIRT6 on also examined.Nasal specimens were used to examine hypoxia-inducible factor (HIF) 1α, LDH, LC3II by Western blot analysis, primary cultures...
Background Olfactory dysfunction significantly influences patients’ quality of life. Chitosan has been reported to support neuron and Schwann cell growth even leads orient axonal growth. However, researchers have yet explore whether chitosan solution can promote differentiation olfactory receptor neurons the neuroepithelium be used for treating dysfunction. Objective To evaluate effect on neuroepithelial cells. Method cells were isolated from embryonic day 17 Wistar rats then cultured with...
The purpose of this study was to investigate the efficacy targeting peptides chemotherapy overcome adverse event in conventional for human hepatocellular carcinoma. Previously we reported several cancer-targeting that bind specifically cancer cells and their vascular endothelia: L-peptide (anti-cancer cell membrane), RLLDTNRPLLPY; SP-94-peptide (anti-hepatoma SFSHHTPILP; PC5-52-peptide (anti-tumor endothelia), SVSVGMKPSPRP; control peptide, RLLDTNRGGGGG. In study, these were linked liposomal...
The influenza A virus (IAV) is an important zoonotic pathogen with infections also reported in dogs. IAV can be detected through the presence of antibodies using enzyme-linked immunosorbent assay (ELISA). Serum only standard sample source; however, there no information on availability other sources for antibody detection Compared serum, plasma more widely employed most animal hospitals. object this study to investigate whether collected ethylenediaminetetraacetic acid (EDTA) tubes (EDTA...
Abstract Background The ethmoid sinus (ES) is a three-dimensional (3D) complex structure, clear understanding of the ES anatomy helpful to plan intranasal surgery. However, most prior studies use 2D measurements, which may not accurately depict 3D structure. current study measured gender differences in morphology based on reconstruction computed tomography (CT) images. Methods models were reconstructed using CT Twenty-one males and 15 females enrolled study. dimensions, including width,...
Oral cancer is one of the most frequently diagnosed human cancers and leading causes death all over world, but prognosis overall survival rate are still poor because delay in diagnosis lack early intervention. The failure due to insufficiency proper diagnostic screening tools patients reluctant undergo biopsy. Optical virtual biopsy techniques, for imaging cells tissues at microscopic details capable differentiating benign from malignant lesions non-invasively, thus highly desirable. A novel...
Background/Aim: Nosocomial infection is a substantial clinical, societal and economic burden, especially during the COVID-19 pandemic. Patients with cancer are required to change into patient gowns before receiving radiotherapy. To improve efficiency control, we designed novel intelligent devices for both gown distribution recycling. We conducted pilot study provide evidence device in healthcare quality improvement. Materials Methods: set up machines an infrared sensor The performance of...
It is generally accepted that oral cancer arises in the presence of precancerous lesions. However, clinical courses these lesions are quite unpredictable, and a fundamental enigma remains when how turn to malignant growth. Characterization potentially thus important could serve as early indicators this neoplastic transformation process, facilitates treatment outcome improves survival rate. Higher harmonic generation microscope (HGM), providing images with <500nm lateral resolution at...