A5058019120- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Nasal Surgery and Airway Studies
- Head and Neck Cancer Studies
- Ear Surgery and Otitis Media
- Obstructive Sleep Apnea Research
- Infectious Diseases and Mycology
- COVID-19 Clinical Research Studies
- Oral and Maxillofacial Pathology
- SARS-CoV-2 and COVID-19 Research
- Respiratory and Cough-Related Research
- Tracheal and airway disorders
- Long-Term Effects of COVID-19
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Medical Imaging and Pathology Studies
- Olfactory and Sensory Function Studies
- Radiopharmaceutical Chemistry and Applications
- Multiple Myeloma Research and Treatments
- Voice and Speech Disorders
- Emotional Labor in Professions
- Problem and Project Based Learning
- Otolaryngology and Infectious Diseases
China Medical University
2014-2025
China Medical University Hospital
2014-2025
National Yang Ming Chiao Tung University
2014-2024
Royal Free London NHS Foundation Trust
2024
Ministry of Health and Welfare
2021
China Medical University
2019
Frimley Park Hospital
2003
Cathay General Hospital
2002
Abstract The coronavirus SARS-CoV-2 is the causative agent of ongoing severe acute respiratory disease pandemic COVID-19. Tissue and cellular tropism one key to understanding pathogenesis SARS-CoV-2. We investigate expression subcellular localization receptor, angiotensin-converting enzyme 2 (ACE2), within upper (nasal) lower (pulmonary) tracts human donors using a diverse panel banked tissues. Here, we report our discovery that ACE2 receptor protein robustly localizes motile cilia airway...
Background/Aim: Studies have demonstrated that patients with HIV are at a higher risk of <i>Pneumocystis jirovecii</i> pneumonia (PJP). Epidemiological knowledge the PJP among infection is lacking. This study aimed to assess HIV. Patients and Methods: cross-sectional was conducted using National Health Insurance Research Database Taiwan. The participants were 18,929 new-onset from 2002 2015. Each patient matched four HIV-negative for age, sex, insured salary, urbanization status, Charlson...
Background: Solid organ transplant (SOT) recipients have an elevated risk of diabetes mellitus (DM). This study investigated the posttransplant DM (PTDM) in a retrospective cohort study. Methods: We analyzed patients aged over 18 years who received SOT between 2002 and 2013. Each patient was matched with four control individuals by age, sex, insured salary, urbanization level, Charlson's comorbidity index (CCI), year inclusion After matching, comprised 6874 underwent 27,496 general as...
In this era of ubiquitous information, patient record exchange among hospitals still has technological and individual barriers including resistance to information sharing. Most research on user attitudes been limited one type or aspect. Because few analyses toward electronic records (EPRs) have conducted, understanding the different users in multiple aspects is crucial acceptance. This proof-of-concept study investigated inter-hospital EPR system implemented nationwide focused discrepant...
We investigated the expression and subcellular localization of SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within upper (nasal) lower (pulmonary) respiratory tracts healthy human donors. detected ACE2 protein cilia organelle ciliated airway epithelial cells, which likely represents initial or early site viral entry during transmission. further determined whether in cells was influenced by patient demographics, clinical characteristics, co-morbidities, medication use, found...
Understanding viral tropism is an essential step toward reducing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, decreasing mortality from disease 2019 (COVID-19) and limiting opportunities for mutant strains to arise. Currently, little known about the extent which distinct tissue sites in human head neck region proximal tract selectively permit SARS-CoV-2 infection replication. In this translational study, we discover key variabilities expression of...
The characteristics and surgical outcomes of central compartment atopic disease (CCAD) vary by region race. Therefore, we aimed to identify the risk factors, symptom severity, prognosis CCAD in Asian population.This case-control study recruited patients diagnosed with chronic rhinosinusitis nasal polyps who underwent functional endoscopic sinus surgery (FESS) at a tertiary hospital Taiwan. Patients were classified into lateral-dominant polyp (LDNP) groups based on computed tomography imaging...
Abstract Evidence shows that chronic rhinosinusitis (CRS) is associated with prior presence of autoimmune diseases; however, large-scale population-based studies in the literature are limited. We conducted a case–control study investigating association between CRS and premorbid diseases by using National Health Insurance Research Database Taiwan. The group included adult patients newly diagnosed 2001 2013. date diagnosis was defined as index date. comparison individuals without CRS, 1:4...
We studied the use of autologous pre-donatedblood transfusion in surgery for scoliosis 45 patients who were divided into two groups; 27 pre-donated blood (group 1) and 18 planned recipients allogenic 2). Normovolaemic haemodilution intra-operative salvage was used six group 1 three 2. The groups did not differ significantly with respect to age, American Society Anaesthesiologists score, mean operative time, number vertebral segments fused, total loss, length stay intensive care hospital....
Our findings suggest that, in Asian patients with severe obstructive sleep apnea (OSA), obesity is a better predictor of uvulopalatopharyngoplasty (UPPP) failure than Friedman stage III.This study evaluated UPPP success rates obese and non-obese treated for OSA.Records who underwent treatment OSA were retrospectively reviewed. Preoperative postoperative apnea/hypopnea index (AHI) Epworth Sleepiness Scale (ESS) score, compared (body mass (BMI) <27 kg/m(2)) (BMI ≥27 patients. Treatment was...
Our study was designed to ascertain the outcomes of functional endoscopic sinus surgery (FESS) combined with submucosal resection (SMR)/septoplasty in reducing FESS revision rates. Retrospective population-based study. Academic tertiary medical center. By using Taiwan Longitudinal Health Insurance Database, we obtained patients who underwent for chronic rhinosinusitis. These were divided into 2 groups: control group (FESS alone) and SMR). The primary outcome operative rate. In total, 4484...
The outcomes management of endoscopic sinus surgery (ESS) is a major effort to improve the quality chronic sinusitis treatment. objective this study was investigate factors that may predict variety ESS.Two hundred and thirty consecutive patients who underwent ESS were prospectively evaluated by computerized axial tomography scan validated survey (CSS) before surgery. effects prognostic then investigated.Extent disease consistent predictor (P < 0.05) for bleeding, complication occurrence,...
The recurrent sinonasal inverted papilloma (IP) could be transformed to squamous cell carcinoma. We use protein expression patterns by immunohistochemical method see whether the of p53, p16, p21, and p27 belongs cell-cycle-regulators PCNA (proliferating nuclear antigen) Ki-67 proliferation markers in sixty patients with papilloma, 10 them carcinoma transformation. Significantly elevated levels Ki-67, p27, IP transformation tract compared were revealed. No variation PLUNC (palate, lung, nasal...
Coronavirus Disease 2019 (COVID-19) is rapidly transmitted from person to person, causing global pandemic since December 2019. Instantly detecting COVID-19 crucial for epidemic prevention. In this study, olfactory dysfunction a significant symptom in mild moderate patients but relatively rare other respiratory viral infections. The Taiwan smell identification test (TWSIT) speedy and inexpensive option accurately distinguishing anosmia that also quantifies the degree of anosmia. Using TWSIT...
Background The efficacy of adjuvant sublingual immunotherapy (SLIT) in correcting structural problems patients with allergic rhinitis (AR) caused by mite who have undergone septomeatoplasty (SMP) has not been studied. Methods This non‐randomized controlled study recruited AR (caused mite) and concurrent septal deviation inferior turbinate hypertrophy, at a tertiary hospital Taiwan. SMP was performed on all as surgical intervention. were then divided into two groups: the control group, which...
Gout is the most common inflammatory arthritis in adult males. Patients with gout are at a higher risk of coronary heart disease (CHD). This study aimed to investigate correlation between and CHD.This was retrospective cohort that used data from Longitudinal Health Insurance Database Taiwan. The subjects were 46,140 patients new-onset during 2003-2010. To avoid selection bias, we propensity score matching. A Cox proportional hazard model analyze differences CHD without after controlling for...
Background: Various diseases involving the cavernous sinus can cause a condition called syndrome (CSS), which is characterized by ophthalmoplegia or sensory deficits over face resulting from compression effect of internal structure. While tumor most reported CSS, statistical data on CSS caused infections are limited. Its risk factors, treatment methods, and clinical outcomes not well-documented. Methods: In this retrospective study, we reviewed patients admitted to tertiary medical center...
OBJECTIVE To undertake cost‐utility analysis for endoscopic sinus surgery (ESS) in order to analyze the cost‐effectiveness of different chronic sinusitis severity groups. METHODS One hundred ninety‐two patients with were evaluated a Chronic Sinusitis Survey (CSS) before and 1‐year after ESS. Direct health care cost data during first year operation retrieved. The utility gain is defined as change CSS total score. ratio was per gain. Patients are stratified by disease using Harvard Staging...
The Chronic Ear Survey (CES) is a valid, disease-specific measure for the evaluation of health status and treatment effectiveness adults with chronic suppurative otitis media (CSOM). This study compares validation properties English Chinese versions CES. CES was translated into Mandarin by means parallel model. version (CCES) administered to 103 patients in prospective manner, then validated according established criteria reliability, validity, longitudinal sensitivity. CCES demonstrated...
Solitary extramedullary plasmacytoma (SEP) is a rare, malignant plasma-cell tumor, which mainly occurs in the head and neck regions. Globally disease has been rarely happening up to 2019, with only about ten papers focused on SEP cases reported English. Thus, literature collectively reviewing characteristics of patients would be valuable.We enrolled 10 patients, recorded their primary sites treatment modality, analyzed survival rates outcomes. We also reviewed previous studies compared...
Most patients with Parkinson’s disease (PD) gradually develop oropharyngeal dysphagia which is often associated pneumonia risk. The possible association of benzodiazepine (BZD) and related drugs (BZRD) use risk has received increasing attention but remains controversial. We investigated the BZDs BZRDs in older adult PD. This case-control study analyzed data 551,975 PD between 2001 2018 Taiwan. To minimize potential confounding, we used 1:4 propensity score matching to include without as...
Abstract Background The prevalence of eosinophilic chronic rhinosinusitis (ECRS) has increased in Taiwan with a higher recurrence rate nasal polyps after surgery. Therefore, we aimed to formulate the pre‐operative diagnostic criteria for patients ECRS Taiwan. Methods This case–control study included diagnosed CRS (CRSwNP) who underwent functional endoscopic sinus surgery (FESS) at tertiary hospital were classified into and non‐eosinophilic (NECRS) groups based on their histopathology....