A5101937696- Bone Metabolism and Diseases
- Connective Tissue Growth Factor Research
- Endodontics and Root Canal Treatments
- Inflammatory mediators and NSAID effects
- Cytokine Signaling Pathways and Interactions
- Oral and Maxillofacial Pathology
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Cancer, Hypoxia, and Metabolism
- Oral and gingival health research
- Bone and Dental Protein Studies
- Biomarkers in Disease Mechanisms
- Cancer Research and Treatments
- TGF-β signaling in diseases
- Protease and Inhibitor Mechanisms
- Oral Health Pathology and Treatment
- Bone Tissue Engineering Materials
- Sirtuins and Resveratrol in Medicine
- Heme Oxygenase-1 and Carbon Monoxide
- interferon and immune responses
- Beetle Biology and Toxicology Studies
- Periodontal Regeneration and Treatments
- dental development and anomalies
- Head and Neck Surgical Oncology
- Otitis Media and Relapsing Polychondritis
National Taiwan University
2011-2025
National Taiwan University Hospital
2012-2024
National Central University
2022
Taipei City Hospital
2012
Far Eastern Memorial Hospital
2012
Taipei Municipal YangMing Hospital
2012
American Association of Endodontists
2010
Rutgers Cancer Institute of New Jersey
2008
Rutgers, The State University of New Jersey
2008
Kaohsiung Medical University
2008
Background: The role of lipopolysaccharide (LPS) in periapical lesion‐induced bone resorption was investigated. Polymyxin B (PMB), a specific inhibitor LPS, evaluated to treat the apical lesion. Methods: Lipopolysaccharide isolated from two common endodontic pathogens, Fusobacterium nucleatum and Porphyromonas endodontalis , stimulated mouse macrophage (J774) release interleukin‐1α (IL‐1α) tumor necrosis factor‐α (TNF‐α) time‐dependent manner. Results: Combination LPS further enhanced...
Mechanical forces have profound effects on endothelial cells. This study was undertaken to examine the hypothesis that tumor necrosis factor-alpha (TNF-alpha) is a potential mediator of stretch-induced matrix metalloproteinase (MMP).Human umbilical vein cells (HUVECs) grown flexible membrane base were stretched by vacuum 20% maximum elongation, at 60 cycles/min. We used TNF-alpha monoclonal antibody and c-Jun N-terminal kinase (JNK) inhibitor, SP600125, investigate cyclical expression MMP-14...
To examine the role of sirtuin-1 (SIRT-1)/FoxO3a in expression cysteine-rich protein 61 (CYR-61) rheumatoid arthritis synovial fibroblasts (RASFs) and influence simvastatin on this pathway, to determine relationship between disease progression FoxO3a/CYR-61 signaling vivo using a rat model collagen-induced (CIA).In RASFs, CYR-61 SIRT-1, localization FoxO3a nucleus/cytoplasm, phosphorylation/acetylation were examined by Western blotting. Secretion CCL20 was assessed enzyme-linked...
Periodontitis is associated with various systemic diseases, potentially facilitated by the passage of Porphyromonas gingivalis outer membrane vesicles (Pg-OMVs). Several recent studies have suggested a connection between Pg-OMVs and neuroinflammation neurodegeneration, but precise causal relationship remains unclear. This study aimed to investigate mechanisms underlying these associations using in vitro models. Isolated were characterized morphology, size, gingipain activity. We exposed...
Abstract Background Vortioxetine, a newer serotonergic antidepressant, has been used to treat adult depressive patients. It reported enhance cognitive functions in While the precise mechanism of action remains unknown, it’ s believed share similarities with selective serotonin reuptake inhibitors (SSRIs). Since previous studies have indicated that SSRIs could alter gut microbial composition, and considering correlation between severity function microbiota through gut-brain axis, we aimed...
Abstract Objective To assess the effects of epigallocatechin‐3‐gallate (EGCG) on oncostatin M (OSM)–induced CCL2 synthesis and associated signaling pathways in human osteoblastic cells. The therapeutic effect EGCG collagen‐induced arthritis (CIA) rats was also studied. Methods c‐Fos messenger RNA expression analyzed by Northern blotting. modulating activation Raf‐1, Akt, phosphatidylinositol 3‐kinase (PI 3‐kinase) were examined coimmunoprecipitation, Western blotting, PI activity assay....
CCN family protein 2 (CCN2), also known as connective tissue growth factor, is a secreting that modulates multiple cellular events. We previously demonstrated the metastasis-suppressive effect of CCN2 in lung cancer cells. In this study, we investigate role anoikis, form programmed cell death critical suppressing metastasis. binds to epidermal factor receptor (EGFR) and triggers ubiquitination by inhibiting formation β-pix/Cbl complex, resulting degradation EGFR. Binding EGFR suppresses...
Elevated glycolytic activity and redox imbalance induced by tissue hypoxia are common phenomena of chronic inflammation, including inflammatory bone diseases such as arthritis. However, relation between glycolysis signaling in the milieu is unclear. The histone deacetylase sirtuin 6 (SIRT6) a crucial modulator inflammation glucose metabolism, it also involved cellular protection against oxidative injury. aims study were to examine connection reactive oxygen species (ROS) production human...
B etel quid chewing is a popular oral habit in India, South Africa, and many Southeast Asian countries. The effects of areca nut (AN) extract on the growth, attachment, protein synthesis healthy human gingival fibroblasts (GF) were investigated to determine why betel (BQ) chewers have higher prevalence periodontal disease than non‐chewers. Twenty‐four hour exposure GF AN (> 200 μg/ml) culture led formation numerous intracellular vacuoles. As analyzed by modified MTT...
To elucidate the pathogenesis of periapical lesion-associated bone resorption, a disease model Wistar rat molar was employed. After lesion induction, mRNAs encoding for matrix metalloproteinase-1 (MMP-1), tissue inhibitor (TIMP-1), interleukin-6 (IL-6), and cyclooxygenase-2 (COX-2) in developing lesions were detected by situ hybridization at day 5, 10, 15 20, respectively. At MMP-1, IL-6 COX-2 appeared predominantly macrophages. During to increased expressions these mediators also found...