A5079896613- Oral Health Pathology and Treatment
- Head and Neck Cancer Studies
- Oral and Maxillofacial Pathology
- Bone health and treatments
- Bone and Joint Diseases
- Bone Tumor Diagnosis and Treatments
- Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Tracheal and airway disorders
- NF-κB Signaling Pathways
- Proteoglycans and glycosaminoglycans research
- Oral and gingival health research
- Fibroblast Growth Factor Research
- Salivary Gland Tumors Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Dysphagia Assessment and Management
- Immunotherapy and Immune Responses
- Tuberculosis Research and Epidemiology
- dental development and anomalies
- Oral and Craniofacial Lesions
- Beetle Biology and Toxicology Studies
- Dental Research and COVID-19
- Dental Anxiety and Anesthesia Techniques
- Inflammatory mediators and NSAID effects
- Endodontics and Root Canal Treatments
National Taiwan University Hospital
2015-2025
National Taiwan University
2014-2025
Mackay Memorial Hospital
2020
Tzu Chi University
2009-2016
China Medical University Hospital
2016
China Medical University
2016
Kaohsiung Chang Gung Memorial Hospital
2008
Kyungpook National University Hospital
2006
Chang Gung Memorial Hospital
2003
Institute of Clinical Research
2001
Betel quid (BQ) chewing is an etiologic factor of oral cancer and submucus fibrosis (OSF). Keratinocyte inflammation crucial for the pathogenesis tissue fibrosis. We found that areca nut (AN) extract (100–400 µg/ml) induced PGE 2 production by KB cells 2.34- to 23.1-fold also TNF-α gingival keratinocytes (GK). Arecoline (0.2–1.2 mM) elevated 2.5- 6.1-fold. AN (200–400 IL-6 GK (7.5- 8.4-fold) cells. In contrast, arecoline (0.1–1.2 suppressed cells, with 42–81 41–63% inhibition, respectively....
The intrusion of an overerupted maxillary molar using traditional orthodontic treatment is a real challenge. aim this study was to investigate the envelope intrusive movements in cases mini-implants as anchorage with partial or full-mouth fixed edgewise appliances. cusp tips pretreatment and postintrusion dental casts were recorded by three-dimensional (3D) digitizer. 3D data serial analyzed distinguish direction magnitude individual tooth movement. mean movement first molars three four mm,...
There are about 200–600 million betel quid (BQ) chewers in the world. BQ chewing is one of major risk factor hepatocarcinoma, oropharyngeal, and esophagus cancers Taiwan, India, Southeast Asian countries. Thus, precise molecular mechanisms deserve investigation. We used cultured primary keratinocytes KB cells, RT-PCR, flow cytometry, Western blotting, ELISA to evaluate whether alterations early gene expression crucial carcinogenic processes BQ. observed induction c-Fos mRNA human gingival...
// Mei-Chi Chang 1, 2 , Jang-Jaer Lee 3, * Yi-Jane Chen 3 Szu-I Lin 4 Li-Deh Eric Jein-Wen Liou Wei-Ling Huang 5 Chiu-Po Chan 2, Chi-Chia 6 and Jiiang-Huei Jeng 1 Biomedical Science Team, Gung University of Technology, Kwei-Shan, Taoyuan City, Taiwan Department Dentistry, Memorial Hospital, Taipei, School Dentistry National Medical College Municipal Kaohsiung, Cardinal Tien New Taipei These authors contributed equally to this work Correspondence to: Jeng, email: jhjeng@ntu.edu.tw Keywords:...
The management of bisphosphonate-related osteonecrosis the jaws (BRONJ) is challenging and controversial. At present, there no established medication treatment for disease.A 78-year-old osteoporotic woman with mandible related to alendronate therapy was referred treatment. disease unresponsive conservative therapy, including antibacterial mouth rinse, antibiotics, minor surgical debridement. Teriparatide, a human recombinant pararthyroid hormone peptide 1-34, then used treatment.The oral...
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS2) is the rate-limiting enzyme of ketogenesis. Growing evidence indicates that HMGCS2 may be involved in cancer progression, but its exact role largely unknown. In this study, we demonstrate mRNA expression associated with poor clinical prognosis and outcomes patients colorectal (CRC) oral squamous cell carcinoma (OSCC). vitro, ectopic enhanced motility a ketogenesis-independent manner. Moreover, promoted Src activity by directly...
Hydroxychavicol (HC; 10 - 50 microM), a betel leaf component, was found to suppress the 2% H(2)O(2)-induced lucigenin chemiluminescence for 53 75%. HC (0.02 2 microM) also able trap superoxide radicals generated by xanthine/xanthine oxidase system with 38 94% of inhibition. Hydroxyl radicals-induced PUC18 plasmid DNA breaks prevented (1.6 16 microM). A 24-h exposure KB cells (0.5, 1 mM) resulted in 54 74% cell death as analysed 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide...
To evaluate postextubation swallowing dysfunction (PSD) 21 days after endotracheal extubation and to examine whether PSD is time-limited age matters. For this prospective cohort study, we evaluated 151 adult critical care patients (≥20 years) who were intubated for at least 48 hours had no pre-existing neuromuscular disease or dysfunction. Participants assessed time (days) pass bedside swallow evaluations (swallow 50 mL of water without difficulty) resume total oral intake. Outcomes compared...
This study aimed to explore the possible association between osteonecrosis of jaws (ONJ) and oral alendronate or raloxifene used for osteoporosis estimate its absolute attributable risks in Taiwanese population.Using an electronic medical records system manual confirmation ONJ, we identified patients who began taking developed ONJ January 2000 April 2012.The incidence associated with management after 1 year drug exposure progressively increased longer durations therapy, specifically from...
Abstract Background Effective biomarkers for oral cancer screening are important early diagnosis and treatment of cancer. Methods Oral epithelial cell samples collected by mouth rinse were obtained from 65 normal control subjects, 108 patients with potentially malignant disorders, 94 squamous carcinoma (OSCC). Methylation levels zinc‐finger protein 582 ( ZNF582 ) paired‐box 1 PAX1 genes quantified real‐time methylation‐specific polymerase chain reaction after bisulfite conversion. Results An...