A5076267056- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Diabetes and associated disorders
- Inflammasome and immune disorders
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- Spondyloarthritis Studies and Treatments
- Curcumin's Biomedical Applications
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Endoplasmic Reticulum Stress and Disease
- Pharmacological Effects of Natural Compounds
- Autophagy in Disease and Therapy
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Retinoids in leukemia and cellular processes
- Cell Adhesion Molecules Research
- Cholesterol and Lipid Metabolism
- Regulation of Appetite and Obesity
- Genomics, phytochemicals, and oxidative stress
- Protease and Inhibitor Mechanisms
- Muscle Physiology and Disorders
The 180th Hospital of PLA
2023-2025
National Cheng Kung University
2025
Huaqiao University
2021-2023
National Yang Ming Chiao Tung University
2018-2023
Shenzhen Luohu People's Hospital
2023
National Chung Hsing University
2006-2010
Type 2 diabetes mellitus (T2DM), with dysregulated hepatic gluconeogenesis as the major cause of fasting hyperglycemia, is closely associated chronic inflammation. We previously demonstrated interleukin‐4 (IL‐4) improves insulin sensitivity and glucose tolerance while reducing lipid deposits. The present study examined in vitro effects IL‐4 on signaling molecules, uptake, metabolism hepatocytes, well vivo adiposity, for elucidating roles energy metabolism. Potential interaction between...
Anti-inflammatory cytokine interleukin-4 (IL-4) promotes glucose tolerance and insulin sensitivity while reduces lipid deposits. However, the effects of IL-4 on energy metabolism in muscle, largest insulin-targeting organ, remain obscure. The study aimed at addressing roles myocyte differentiation (myogenesis) muscle cells. Effects myogenesis, interaction between C2C12 myoblasts terminal differentiated myocytes were analyzed. improved GLUT4 translocation tended to elevate uptake by boosting...
Cytokines, costimulatory and counter-regulatory molecules play important roles in the regulation of inflammatory response, are good candidates involved development ankylosing spondylitis (AS). This study investigated genotypic distribution proinflammatory cytokines T-cell negative regulator cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) healthy subjects AS patients. Genomic DNA was extracted from 143 patients 166 ethnic-matched subjects. Nine polymorphisms within genes interleukin-4...
1. Abenavoli, L., Larussa, T., Corea, A., Procopio, A.C., Boccuto, Dallio, M., Federico, Luzza, F. (2021). Dietary polyphenols and non-alcoholic fatty liver disease. Nutrients, 13(2), art. no. 494. https://doi.org/10.3390/nu1302.... CrossRef Google Scholar
The antioxidant activity of curcumin has been extensively investigated for years. However, its molecular function mechanism remained unclear. Our preliminary study showed that downregulated miR-22-3p expression. This aimed to address whether mediated the and possible action mechanism. results repression increased total cellular capacity enhanced endogenous enzyme system LO2 cells. In addition, miR-22-3p-deteriorated was prevented by pretreatment. Moreover, inhibition significantly improved...
Abstract Human leukocyte antigen (HLA) polymorphism is hypothesized to be associated with diverse immune responses toward infectious diseases. Herein, by comparing against multiple subpopulation groups as control, we confirmed that HLA-B*15:27 and HLA-DRB1*04:06 were coronavirus disease 2019 susceptibility in China. Both alleles predicted have weak binding affinities viral proteins.
Objective: Oxidative stress represents a characteristic of neurodegenerative diseases, which may be alleviated by the functional food component—curcumin. However, underlying mechanism remains unclear. The current study aimed to address how curcumin protects variant differentiated pheochromocytoma (PC12) cells against hydrogen peroxide (H 2 O )-induced cell stress, using low- and high-differentiated PC12 cells, validated in old-aged mice. Methods: MTT assay was first carried out test...
Type 2 diabetes mellitus (T2DM) is associated with chronic inflammation, suggesting the metabolic abnormalities are originated from or exacerbated by cytokine overproduction. Cytokines and counter-regulatory molecules crucial in keeping balance of immune responses and, therefore, potential candidates involved T2DM etiology, development complications. Our previous reports identify several significant associations between genotypes genes and/or clinical lipid parameters, which strongly suggest...
Elevated resistin levels and the polymorphisms located at gene encoding (<em>RETN</em>) are associated with diabetic pathogenesis. However, correlation between <em>RETN</em> genotypes T2DM is controversial due to discrepancies among reports. This study aimed investigating clarifying putative association of in Taiwanese population. The -420C>G 244 control 305 subjects were examined. Meanwhile, genetic polymorphism levels, as well subjects' clinical characteristics was statistically...
Obesity often increases the risk of cancer and worsens prognosis. Unlike most types cancer, several studies concluded that obesity had an inverse influence on LUAD survival. Increasing evidence showed obesity-related adipocyte-derived lncRNAs were associated with initiation, progression, drug resistance, tumor microenvironment in lung cancer. In present study, we identified two BMI-associated (LINC01500 lnc-MAFB-1) could potentially regulate progression LUAD. Both downregulated significantly...
Abstract Background: Obesity often increases the risk of cancer and worsens prognosis. Unlike most types cancer, obesity lung displayed a mixed relationship. Several studies concluded that had an inverse impact on incidents benefited overall survival, with few underlying mechanisms understood. Obesity-related adipocytes-derived lncRNAs been reported to deregulate cancer-associated pathways. Here we conducted this study identify potential BMI-associated their roles in cancer. Methods: We...