A5049271629- Bone Tissue Engineering Materials
- Oral microbiology and periodontitis research
- Dental Implant Techniques and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Oral and gingival health research
- Immune Response and Inflammation
- Advanced machining processes and optimization
- Acute Kidney Injury Research
- Neonatal Respiratory Health Research
- Cell Adhesion Molecules Research
- Hydrogels: synthesis, properties, applications
- Mesenchymal stem cell research
- Genomics and Phylogenetic Studies
- 3D Printing in Biomedical Research
- Urticaria and Related Conditions
- Phagocytosis and Immune Regulation
- Advanced Numerical Analysis Techniques
- Orthopaedic implants and arthroplasty
- Vascular Malformations and Hemangiomas
- Salivary Gland Disorders and Functions
- Additive Manufacturing and 3D Printing Technologies
- Infective Endocarditis Diagnosis and Management
- Hedgehog Signaling Pathway Studies
- Dental materials and restorations
- Protease and Inhibitor Mechanisms
Taipei Medical University
2000-2022
Wan Fang Hospital
2002-2022
Taipei Medical University Hospital
2007
National Taiwan University
2007
Boston University
2002
ABSTRACT Porphyromonas gingivalis is an oral pathogen that has recently been associated with chronic inflammatory diseases such as atherosclerosis. The strength of the epidemiological associations P. atherosclerosis can be increased by demonstration initiate and sustain growth in human vascular cells. We previously established invade aortic, heart, umbilical vein endothelial cells (HUVEC), fimbriae are required for invasion cells, fimbrillin peptides induce expression chemokines interleukin...
ABSTRACT Recent cross-sectional and prospective epidemiological studies have demonstrated an association between periodontal disease atherosclerosis human coronary heart disease. Previously, we established that the pathogen Porphyromonas gingivalis is capable of invading aortic, heart, umbilical vein endothelial cells (HUVEC). Since a chronic inflammatory response initiated at vascular wall, interactions P. with subsequent host cell to infection may be important in pathogenesis...
Tumor necrosis factor-alpha (TNF-alpha) exerts its functions by binding two different receptors (TNFR55 and TNFR75). Both TNFR55 TNFR75 exist in cell-associated soluble forms. Soluble TNF (sTNFR), sTNFR55 sTNFR75, are proteolytically shed upon inflammatory stimuli then modulate various TNF-alpha bioactivities. As human gingival fibroblasts (HGF) can be potential targets for inflamed gingiva, we hypothesized that HGF partially the cellular responses to regulating their own TNFR. In this...
The purpose of this study was to clarify the main contributory factor nifedipine-induced gingival overgrowth either by Porphyromonas gingivalis lipopolysaccharide ( Pg-LPS) or interleukin-1beta (IL-1β). Human fibroblasts from healthy tissues and were stimulated with nifedipine, IL-1β, Escherichia coli Ec-LPS), Pg-LPS, gene expressions analyzed RT-PCR. Analysis data showed no strong evidence a synergistic effect nifedipine Pg-LPS on IL-6, connective tissue growth (CTGF), type 1 collagen...
This study aimed to elucidate the local effect and micro-computed tomographic (μ-CT) assessment following bone implantation of an innovative bioceramic (α-calcium sulfate hemihydrate; α-CSH) on femur lateral condyle cortical rabbit models. The α-CSH was synthesized through a green processing technology (microwave irradiation treatment). bilateral model performed among 24 New Zealand White rabbits which were divided into three groups based type filling materials: α-CSH, control, blank....
The ability of Pluronic F127 (PF127) conjugated with tetrapeptide Gly-Arg-Gly-Asp (GRGD) as a sequence Arg-Gly-Asp (RGD) peptide to form the investigated potential hydrogel (hereafter referred 3DG bioformer (3BE)) produce spheroid, biocompatibility, and cell invasion ability, was assessed in this study. fibroblast line (NIH 3T3), osteoblast (MG-63), human breast cancer (MCF-7) were cultured 3BE commercial product (Matrigel) for comparison. morphology spheroid formation evaluated via optical...
In the original publication, there was a mistake in Figure 2a as published [...]
This study examined the uniformity of illuminance field distributions light guide plates (LGPs). First, authors designed microstructural patterns on surface an LGP. Then, a mold LGP with optimal design was fabricated by photolithography method. Micro-injection molding (μIM) used to manufacture molded LGPs. μIM technology can simultaneously large-sized wedge-shaped LGPs and micro-scale microstructures. Finally, values various microstructures were obtained through optical measurements....
The present study aimed to synthesize biphasic calcium phosphate ceramics (CaPs) composed of β-tricalcium (β-TCP) and hydroxyapatite (HAp) from the propagated Scleractinian coral dicalcium anhydrous using a solid-state reaction followed by heat treatment at temperature 1100 °C for 1 h 7 days. as-prepared coral-derived CaPs samples were characterized through scanning electron microscopy, X-ray diffractometry, Fourier transform infrared spectroscopy, Raman spectroscopy. cell response was...
Abstract not Available.
Objective: Long exposure of argon plasma coagulation (APC) causes thermal damage and apoptosis in tissues. However, whether the APC-induced tissues involves expression NF-κB caspase-3 remains undetermined. In this study, we compared effect APC on liver at two different time tested hypothesis that injuries induced by are accompanied induction rat liver.Material Methods: Liver were rats an device with pulse mode for 2 or 4 seconds under same frequency power (40W). The animals sacrificed 0, 3,...
Micro-arc oxidation (MAO) is one of the most potential methods to generate hybrid micro/nanostructural surfaces on Ti dental implant because its simplicity, high efficiency and low cost. The MAO surface-treated (MST-Ti) implants have also been shown good biocompatibility by in vitro vivo evaluation interfacial behaviors bone tissue. From a clinical point view, it would be desirable if traditional could developed as osseointegration accompany with elastic modulus avoid stress-shielding...
DNAプローブを用いたコロニーハイブリダイゼーション法による細菌同定は, 簡便性と定量性に優れ, 病原性細菌の検出・同定法として用いられている。本研究では, 歯周病細菌同定により特異性を持たせるために, この方法を応用して, 近年, 細菌の系統分類に用いられるようになった細菌16SリボソームRNA rRNA) 遺伝子をDNAプローブとして利用した。歯周病細菌のActinobacillzas actinomycetemcomitans, (Por-phyromonas gingivalisおよびPrevotella intermediaの16SrRNA遺伝子塩基配列から菌種特異的な可変領域を検索し, DNAプローブを作成した。このDNAプローブの上記3菌種16SrRNAに対する特異性をノーザンハイブリダイゼーション法で確認した。また, これらのDNAプローブが他の口腔細菌種に対して交差反応性がないことをドットプロットハイブリダイゼーション法で確認した。そこで, これらのDNAプローブを, 上記3菌種の標準菌株を用いたコロニーハイブリダイゼーション法による細菌同定に取り入れ,...
In this study, we proposed an innovative three-dimensional (3D) printed porous (termed as 3DPP) scaffold composed of bioceramic (beta-tricalcium phosphate (β-TCP)) and thermoreversible biopolymer (pluronic F-127 (PF127)) that can provide bone tissue ingrowth loading support for defect treatment. Three types 3DPP scaffolds were in different line spaces comparison (3DPP-1: 0.7 mm, 3DPP-2: 0.8 3DPP-3: 0.9 mm). The material properties the characterized using scanning electron microscopy, X-ray...