A5080432188- Pharmacological Effects and Toxicity Studies
- Neurosurgical Procedures and Complications
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Cerebral Venous Sinus Thrombosis
- Lipoproteins and Cardiovascular Health
- Moyamoya disease diagnosis and treatment
- Neurological disorders and treatments
- Cerebrospinal fluid and hydrocephalus
- Pharmacogenetics and Drug Metabolism
- Meta-analysis and systematic reviews
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and genetic disorders
- Pharmaceutical studies and practices
- BRCA gene mutations in cancer
- Autoimmune Neurological Disorders and Treatments
- Protein Tyrosine Phosphatases
- Traditional Chinese Medicine Studies
- Genetic Associations and Epidemiology
- Atherosclerosis and Cardiovascular Diseases
- Ginkgo biloba and Cashew Applications
- Advanced Glycation End Products research
- Optical Imaging and Spectroscopy Techniques
Taichung Veterans General Hospital
2013-2025
National Chung Hsing University
2022-2025
Taipei Veterans General Hospital
2024
National Taipei University
2024
National Taiwan University
2024
National Yang Ming Chiao Tung University
2015-2022
University of Kentucky
1978
This case describes asymmetrical dystonia and hypokinesia in anti-Ma2 encephalitis, where interictal ictal occurred contralaterally to the side with more frequent epileptic activity. In August 2018, a 22-year-old right-handed male presented diurnal double vision. Four months later, he developed severe psychosis, disinhibited behavior, memory impairment, leading diagnosis of schizophrenia. Two years experienced focal impaired awareness seizures (FIAS) accompanied by intermittent left-hand...
Objective The objective of this article is to elucidate the outcome, prognostic predictors and timing surgical intervention for subdural hematoma (SDH) in patients with spontaneous intracranial hypotension (SIH). Methods Patients SDH were identified retrospectively from 227 consecutive SIH patients. Data collected on demographics, clinical courses, neuroimaging findings, treatment SDH, which was later divided into conservative treatment, epidural blood patches (EBP), intervention. Poor...
Brain cortico-subcortical connectivity has been investigated in epilepsy using the functional MRI (MRI). Although structural images cannot demonstrate dynamic changes, they provide higher spatial resolution, which allows exploration of organization brain greater detail. We used high-resolution to study hippocampal-thalamic-cortical networks temporal lobe (TLE) a volume-based morphometric method. enrolled 22 right-TLE, 33 left-TLE, and 28 age/gender-matched controls retrospectively....
Background Most diagnostic tools for spontaneous intracranial hypotension (SIH) are either invasive or occasionally inconsistent with the clinical condition. In this study, we examined cerebrospinal fluid (CSF) dynamics in SIH using phase-contrast magnetic resonance (PC-MR) imaging. Materials and method Seventeen patients 32 healthy individuals, matched by sex age, were recruited. Each person underwent brain PC-MR imaging 3-Tesla MRI. We evaluated differences image parameters among during...
Abstract The Taiwan Precision Medicine Initiative (TPMI), a project initiated by the Academia Sinica in collaboration with 16 major medical centers around Taiwan, has recruited 565,390 participants who consented to provide DNA samples for genetic profiling and grant access their electronic records (EMR) studies develop precision medicine. Access EMR is both retrospective prospective, allowing researchers conduct prospective over time. Genetic done population-optimized SNP arrays Han Chinese...
Background Spontaneous intracranial hypotension (SIH) is often misdiagnosed, and can lead to severe complications. Conventional MR sequences show a limited ability aid in this diagnosis. MR‐based pressure (MR‐ICP) may be able detect changes of elastance pressure. Purpose To determine whether MR‐ICP differentiate SIH patients from normal subjects, improve diagnostic sensitivity, provide an insight into the pathophysiology. Study Type Prospective. Subjects Twenty‐eight cases with orthostatic...
New Findings What is the central question of this study? Imbalance activities between GABAergic and glutamatergic systems involved in epilepsy. It not known whether simultaneously increasing decreasing activity using valproic acid ceftriaxone, respectively, leads to better seizure control. Ceftriaxone suppressed cognitive deficits restored neuronal density number newborn cells hippocampus a rat model Combined treatment with ceftriaxone showed additive effects suppression. Abstract The...
Objectives: Statins have anti–inflammatory effects on several neurological diseases. However, their post-stroke epilepsy and mortality not been well studied.Method: This is a retrospective cohort study, based the one-million random data from National Health Insurance Research Database (NHIRD) of Taiwan. We identified stroke inpatients during 2000–2009. They were grouped into statin users non-users, followed up to 2010. Excluded those with in-hospital mortality, seizure(s), epileptic history,...
This is the first study to use functional near-infrared spectroscopy (fNIRS) investigate how lateralization of epileptogenic zone affects reconfiguration task-related network patterns. Eleven left fronto-temporal epilepsy (L-FTE) and 11 right (R-FTE), as well 22 age- gender-matched controls, were enrolled. Signals from 52-channel fNIRS recorded while subject was undertaking verbal fluency tasks (VFTs), which included categorical (CFT) letter (LFT) tasks. Three analytic methods used topology:...
Epilepsy, which is caused by abnormal neuronal firing in the brain, a common neurological disease and affects motor cognitive functions. Excessive levels of glutamate insufficient inhibitory GABA are involved its pathophysiology. Valproic acid (Val), GABAergic agonist, one first-line antiepileptic drugs, but it shows many adverse side effects at clinical dose. Clavulanic (CA), β-lactamase inhibitor, has been demonstrated to increase transporter-1 expression. This study evaluated CA Val an...
Familial hypercholesterolemia (FH) is a common genetic disorder characterized by lifelong elevated low-density lipoprotein cholesterol (LDL-C) level. The relationship between FH and ischemic stroke still controversial. We enrolled patients prospectively in our neurological ward, divided them into two groups according to LDL-C levels with threshold of 130 mg/dl. Targeted sequencing was performed all for LDLR, APOB, PCSK9 genes. fifty-eight high-LDL subjects were older, prevalence previous...
Background: Familial hypercholesterolemia (FH) has been associated with early coronary artery disease (CAD) and increased risk of atherosclerotic cardiovascular disease. However, the prevalence FH its long-term outcomes in a CAD-high-risk cohort, defined as patients hypercholesteremia who underwent angiography, remains unknown. Besides, studies regarding impact genetic variations on (CV) are scarce. Methods Results: In total, 285 hospitalized for angiography blood low-density lipoprotein...
Letter fluency task (LFT) is a tool that measures memory, executive function, and language function but lacks definite cutoff value to define abnormalities. We used the optical signals of functional near-infrared spectroscopy (fNIRS) study differences in power connectivity between high-functioning low-functioning participants while performing three successive LFTs, as well relationships brain network/power LFT performance. found most differentiating factor these two groups was network...
Introduction Dementia is associated with many comorbidities while being related to Apolipoprotein E ( ApoE ) polymorphism. However, it unclear how these clinical illnesses and genetic factors modify the dementia risk. Methods We enrolled 600 cases 6000 matched non-dementia controls, identified genotype (ε4/ε4, ε4/ε3, ε3/ε3). Eight were selected by medical records, counted if occurring within 3 years of enrollment. Results The group had a higher ratio carrying ε4 allele prevalence than group....
The patient, a manic depressive who was treated with lithium for three years, suddenly developed severe neurotoxicity and glomerulonephritis-like syndrome. author believes that the toxicity facilitated by hot weather excessive sweating, gall bladder pathology fever, decreased water salt intake. patient improved except persistent hypertension. Propranolol not only hypertension but alleviated lithium-induced tremor as well.
Dementia is a global public health concern. This study focuses on the genetic factors underlying dementia. We analyzed electronic medical records (EMR) from Taichung Veterans General Hospital, Taiwan, to confirm differences between dementia and non-dementia patients. work was supported by Taipei Medical University [TMU111-AE1-B45].
pathologic variants cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), which presents stroke dementia is characterized by white matter hyperintensities (WMHs) on brain MRI. The R544C variant a common in Taiwan, but not all carriers exhibit significant symptoms. We investigated whether WMHs occur before clinical symptoms pathogenic variants, examined factors associated WMHs, explored their relationship cognitive functions.
ABSTRACT Incorporating pharmacogenetics into clinical practice promises to improve therapeutic outcome by choosing the medication and dosage optimized for a patient based on genetic factors that affect drug response 1 . One of most promising benefits PGx-guided therapy is avoidance adverse reactions 2 To evaluate impact PGx risk variants outcomes, we performed retrospective study analyzed data from largest Han Chinese cohort assembled Taiwan Precision Medicine Initiative. We found nearly all...
DNA sequencing of patients with rare disorders has been highly successful in identifying "causal variants" for numerous conditions. However, there are many reports healthy individuals who harbor these deleterious variants, leading to the concept incomplete penetrance and doubt about utility genetic testing clinical practice population screening. As variants rare, is largely unknown. We analyzed data from 486,956 participants Taiwan Precision Medicine Initiative (TPMI) determine risk...
<title>Abstract</title> DNA sequencing of patients with rare disorders has been highly successful in identifying ''causal variants'' for numerous conditions. However, there are many reports healthy individuals who harbor these deleterious variants, leading to the concept incomplete penetrance and doubt about utility genetic testing clinical practice population screening. As variants rare, is largely unknown. We analyzed data from 486,956 participants Taiwan Precision Medicine Initiative...
<title>Abstract</title> Incorporating pharmacogenetics into clinical practice promises to improve therapeutic outcome by choosing the medication and dosage optimized for a patient based on genetic factors that affect drug response<sup>1</sup>. One of most promising benefits PGx-guided therapy is avoidance adverse reactions<sup>2</sup>. To evaluate impact PGx risk variants outcomes, we performed retrospective study analyzed data from largest Han Chinese cohort assembled Taiwan Precision...