A5102937164- Aquaculture disease management and microbiota
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Aquaculture Nutrition and Growth
- Autophagy in Disease and Therapy
- Protein Hydrolysis and Bioactive Peptides
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Mosquito-borne diseases and control
- Meta-analysis and systematic reviews
- Physiological and biochemical adaptations
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Cellular transport and secretion
- Reproductive biology and impacts on aquatic species
- Neurobiology and Insect Physiology Research
- Microbial Metabolism and Applications
- melanin and skin pigmentation
- Traditional Chinese Medicine Analysis
- T-cell and B-cell Immunology
- Studies on Chitinases and Chitosanases
- Erythrocyte Function and Pathophysiology
- Antimicrobial Peptides and Activities
- Developmental Biology and Gene Regulation
- Lipid Membrane Structure and Behavior
Institute of Biomedical Sciences, Academia Sinica
2024
Nagoya University
2022-2023
Fujita Health University
2022-2023
Fujita Health University Hospital
2023
Capital Medical University
2021-2023
Fujian Agriculture and Forestry University
2019-2022
Ocean University of China
2017-2021
IL-2 is a pleiotropic cytokine that critical for T cell immunity. Although the IL-2-mediated regulation of immunity in mammals relatively well understood, it remains largely unknown whether and how regulates lower vertebrates. To address this knowledge gap, we investigated role played by response, as associated underlying mechanisms teleost fish, large yellow croaker (Larimichthys crocea). We found (L. crocea) (LcIL-2) significantly promoted proliferation both vivo vitro; induced...
Hadal environments (depths below 6,000 m) are characterized by extremely high hydrostatic pressures, low temperatures, a scarce food supply, and little light. The evolutionary adaptations that allow vertebrates to survive in this extreme environment poorly understood. Here, we constructed high-quality reference genome for Yap hadal snailfish (YHS), which was captured at depth of ~7,000 m the Trench. final YHS assembly 731.75 Mb, with contig N50 0.75 Mb scaffold 1.26 Mb. We predicted 24,329...
During reward-based learning tasks, animals make orofacial movements that globally influence brain activity at the timings of reward expectation and acquisition. These are not explicitly instructed typically appear along with goal-directed behaviors. Here, we show reinforcing optogenetic stimulation dopamine neurons in ventral tegmental area (oDAS) mice is sufficient to induce whiskers nose without accompanying Pavlovian conditioning a sensory cue oDAS elicited cue-locked oDAS-aligned...
Neuropeptides play essential roles in regulation of reproduction and growth marine molluscs. But their function bivalves - a group animals commercial importance is largely unexplored due to the lack systematic identification these molecules. In this study, we sequenced analyzed transcriptome nerve ganglia Yesso scallop Patinopecten yessoensis, from which 63 neuropeptide genes were identified based on BLAST de novo prediction approaches, 31 confirmed by proteomic analysis using liquid...
Simultaneous or functional hermaphrodites possessing both ovary and testis at the same time are good materials for studying sexual development. However, previous research on sex determination differentiation was mainly conducted in gonochoristic species studies simultaneous still limited. In this study, we a combined morphological, endocrine molecular study gonadal development of hermaphroditic scallop Argopecten irradians aged 2–10 month old. Morphological analysis showed that occurred 6...
Abstract β‐defensin (BD) is a cysteine‐rich cationic antibacterial peptide that active against wide range of bacteria. Here, homolog ( Lc BD2) was identified in large yellow croaker Larimichthys crocea ). The open reading frame BD2 contains 195 nucleotides, encoding protein 64 amino acids possesses typical arrangement six conserved cysteine residues (C 31 , C 37 41 53 59 and 60 transcripts were constitutively expressed all examined tissues significantly increased head kidney, spleen gills by...
Abstract Recent work has revealed that spontaneous release plays critical roles in the central nervous system, but how it is regulated remains elusive. Here, we report synaptotagmin‐11 (Syt11), a Ca 2+ ‐independent Syt isoform associated with schizophrenia and Parkinson's disease, suppressed release. Syt11‐knockout hippocampal neurons showed an increased frequency of miniature excitatory post‐synaptic currents while over‐expression Syt11 inversely decreased frequency. Neither knockout nor...
Synaptic vesicle (SV) endocytosis is a critical and well-regulated process for the maintenance of neurotransmission. We previously reported that synaptotagmin-11 (Syt11), an essential non-Ca 2+ -binding Syt associated with brain diseases, inhibits neuronal (Wang et al., 2016). Here, we found Syt11 deficiency caused accelerated SV recycling under sustained stimulation led to abnormal membrane partition synaptic proteins in mouse hippocampal boutons either sex. Furthermore, our study revealed...
Body movements influence brain-wide neuronal activities. In the sensory cortex, thalamocortical bottom-up inputs and motor-sensory top-down are thought to affect dynamics of membrane potentials ( V m ) neurons change their processing information during movements. However, direct perturbation axons projecting cortex from other remote areas has remained unassessed, therefore interareal circuits generating motor-related signals in cortices remain unclear. Using a G i/o -coupled opsin, eOPN3, we...
DNA sequencing of patients with rare disorders has been highly successful in identifying "causal variants" for numerous conditions. However, there are many reports healthy individuals who harbor these deleterious variants, leading to the concept incomplete penetrance and doubt about utility genetic testing clinical practice population screening. As variants rare, is largely unknown. We analyzed data from 486,956 participants Taiwan Precision Medicine Initiative (TPMI) determine risk...
<title>Abstract</title> DNA sequencing of patients with rare disorders has been highly successful in identifying ''causal variants'' for numerous conditions. However, there are many reports healthy individuals who harbor these deleterious variants, leading to the concept incomplete penetrance and doubt about utility genetic testing clinical practice population screening. As variants rare, is largely unknown. We analyzed data from 486,956 participants Taiwan Precision Medicine Initiative...
ABSTRACT During reward-based learning tasks, animals make orofacial movements that globally influence brain activity at the timings of reward expectation and acquisition. These are not explicitly instructed typically appear along with goal-directed behaviors. Here we show reinforcing optogenetic stimulation midbrain dopamine neurons (oDAS) in mice is sufficient to induce whiskers nose without accompanying Pavlovian conditioning a sensory cue oDAS elicited cue-locked aligned movements, which...
Abstract Body movements, especially orofacial are known to influence brain-wide neuronal activity. In the sensory cortex, thalamocortical bottom-up inputs and motor-sensory top-down thought affect dynamics of membrane potentials (V m ) neurons change their processing information during movements. However, direct perturbation axons projecting cortex from other remote areas movements has remained unassessed, therefore interareal circuits generating motor-related signals in cortices still...
Abstract Membrane trafficking pathways mediate key microglial activities such as cell migration, cytokine secretion, and phagocytosis. However, the underlying molecular mechanism remains poorly understood. Previously, we found that synaptotagmin‐11 (Syt11), a non‐Ca 2+ ‐binding Syt associated with Parkinson's disease (PD) schizophrenia, inhibits release phagocytosis in primary microglia. Here reported vivo function of Syt11 immune responses using an inducible microglia‐specific...