Lii-Jia Yang
A5067116978- Heart Failure Treatment and Management
- Hepatitis B Virus Studies
- Pharmaceutical studies and practices
- Pharmacogenetics and Drug Metabolism
- Potassium and Related Disorders
- Liver Disease Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Pharmacological Effects and Toxicity Studies
- Traditional Chinese Medicine Studies
- Blood Pressure and Hypertension Studies
- Immune Response and Inflammation
- Hepatitis C virus research
- BRCA gene mutations in cancer
- HIV, Drug Use, Sexual Risk
- Hormonal Regulation and Hypertension
- Muscle and Compartmental Disorders
- Hepatitis Viruses Studies and Epidemiology
- Renal function and acid-base balance
- Immune Cell Function and Interaction
- Electrolyte and hormonal disorders
- Immunotherapy and Immune Responses
Kaohsiung Medical University
2018-2024
Kaohsiung Medical University Chung-Ho Memorial Hospital
2018-2024
Digoxin is commonly prescribed for heart failure and atrial fibrillation, but there limited data on its safety in patients with chronic kidney disease (CKD). We conducted a population-based cohort study using the pre-end stage renal (ESRD) care program registry National Health Insurance Research Database Taiwan. Of advanced CKD patient (N = 31,933), we identified digoxin user group 400) matched age sex non-user 2,220). Multivariable Cox proportional hazards sub-distribution models were used...
Background Thiazide, a first-line therapy for hypertension, lowers blood pressure, increases bone mineral density, and reduces the risk of fractures. However, hyponatremia, an adverse effect thiazide, is associated with increased osteoporosis It currently unclear whether thiazide-associated hyponatremia (TAH) outweighs protective effects thiazide. Methods Using data from Taiwan's National Health Insurance Research Database, we identified patients who were prescribed thiazide between 1998...
Hepatitis B virus (HBV), hepatitis C (HCV), and tuberculosis (TB) infections affect patient morbidity mortality challenge infection control procedures within dialysis facilities. Thus, updated information on the yearly trends in population is pivotal to preventing improving management of these infectious diseases. This study used reimbursement data from Taiwan National Health Insurance Research Database. Long-term hemodialysis (HD) patients were defined as those receiving regular HD for more...
ABSTRACT Though it is well established that gamma interferon (IFN-γ) crucial to the early innate defense of murine listeriosis, its sources remain controversial. In this study, intracellular cytokine staining IFN-γ-expressing splenocytes after Listeria monocytogenes infection revealed NK1.1 + , CD11c CD8 T, and CD4 T cells expressed IFN-γ 24 h infection. Contrary previous report, most dendritic (DC) were CD8α − DC. Unexpectedly, almost all also NK1.1. These represented primary situ studies...
The management of the coexistence heart disease and kidney is increasingly challenging for clinicians. Chronic (CKD) not only a prevalent comorbidity patients with failure but has also been identified as noteworthy risk factor all-cause mortality poor clinical outcomes. Digoxin one commonest treatments disease. There are few trials investigating role digoxin in cardiorenal syndrome (CRS). This study aims to examine association between usage outcomes CRS nationwide cohort.We conducted...
ABSTRACT Incorporating pharmacogenetics into clinical practice promises to improve therapeutic outcome by choosing the medication and dosage optimized for a patient based on genetic factors that affect drug response 1 . One of most promising benefits PGx-guided therapy is avoidance adverse reactions 2 To evaluate impact PGx risk variants outcomes, we performed retrospective study analyzed data from largest Han Chinese cohort assembled Taiwan Precision Medicine Initiative. We found nearly all...
<title>Abstract</title> Incorporating pharmacogenetics into clinical practice promises to improve therapeutic outcome by choosing the medication and dosage optimized for a patient based on genetic factors that affect drug response<sup>1</sup>. One of most promising benefits PGx-guided therapy is avoidance adverse reactions<sup>2</sup>. To evaluate impact PGx risk variants outcomes, we performed retrospective study analyzed data from largest Han Chinese cohort assembled Taiwan Precision...
A high ultrafiltration rate (UFR) is associated with increased mortality in hemodialysis patients. However, whether a UFR itself or heart failure fluid overload followed by causes remains unknown. In this study, 2615 incident patients were categorized according to their initial cardiothoracic ratios (CTRs) assess was low CTRs. total, 1317 (50.4%) women and 1261 (48.2%) diabetic. During 2246 (1087−3596) days of follow-up, 1247 (47.7%) cases all-cause noted. quintiles 4 5 higher risks than...