Background and objectives Fluid overload is a common characteristic associated with renal progression in CKD. Additionally, fluid an independent predictor of all-cause or cardiovascular mortality patients on dialysis, but its influence not dialysis uncertain. The aim the study was to assess relationship between severity status clinical outcomes advanced CKD cohort. Design, setting, participants, & measurements In total, 478 predialysis stages 4 5 integrated care program were enrolled from...

Hyperuricemia is an independent risk factor for mortality, cardiovascular disease, and renal disease in general population. However, the relationship between hyperuricemia with clinical outcomes CKD remains controversial.The study investigated association uric acid all-cause events, replacement therapy, rapid progression (the slope of estimated GFR was less than -6 ml/min per 1.73 m(2)/y) 3303 stages 3-5 patients that were integrated care system one medical center regional hospital southern...

Dyslipidemia is highly prevalent in patients with chronic kidney disease (CKD) and the relationship between dyslipidemia renal outcomes moderate to advanced CKD remains controversial. Hence, our objective determine whether independently associated rapid progression replacement therapy (RRT) patients. The study analyzed association lipid profile, RRT, (estimated glomerular filtration rate [eGFR] slope <-6 ml/min/1.73 m(2)/yr) 3303 stages 3 5 CKD. During a median 2.8-year follow-up, 1080...

Abstract Context Type 2 diabetes (T2D) is the major contributor to chronic kidney disease and end-stage (ESKD). The influence of trimethylamine N-oxide (TMAO) on outcomes in T2D remains unclear. Objective To examine association between fasting serum TMAO levels adverse patients with T2D. Methods Between October 2016 June 2020, were recruited monitored every 3 months until December 2021. Serum assessed using liquid chromatography-mass spectrometry. primary doubling creatinine or progression...

Background: Amyotrophic lateral sclerosis (ALS) is a rare disease in Taiwan; thus, estimation of ALS mortality difficult. We evaluated factors associated with survival Taiwan.Methods: The study enrolled 1149 Taiwanese primary diagnosis during 1999–2008. Follow-up information was available for all patients; mean (SD) duration follow-up 2.91 (2.62) years. Medical interventions, including noninvasive positive pressure ventilation (NIPPV), tracheotomy, gastrostomy, and riluzole, were included...

Patients with chronic kidney disease (CKD) are more readily prone to have impaired physical activity than the general population. The aim of this study is examine relationship between and adverse clinical outcomes quality life (QOL) in CKD. One hundred sixty-one patients CKD stages 1-5 was enrolled from February 2013 September followed up until June 2016. Physical measured using high handgrip strength, 30-second chair stand, 2-minute step. QOL assessed Taiwan version World Health...

Background/Objectives: Autosomal dominant polycystic kidney disease (ADPKD) is a progressive genetic disorder marked by bilateral renal cysts and extrarenal manifestations, ultimately resulting in failure. Emerging research indicates that metformin might influence the intracellular mechanisms of ADPKD, though its clinical significance remains uncertain. Methods: We applied Taiwan National Health Insurance Database (NHIRD) to investigate impact utilization ADPKD patients real-world practice....

Background Cognitive decline causes disability and dependence in older people, affecting the individuals, families society. This study aimed to use a gamified smart test, CogMate™, measure cognitive function of community-dwelling people compare test with Mini-Mental State Examination (MMSE). Methods We recruited 150 for testing two assessment tools, MMSE CogMate™. After completing data collection, we conducted descriptive inferential statistical analyses. Results The results showed that only...

Abstract Objective Machine learning (ML) algorithms are promising tools for managing anemia in hemodialysis (HD) patients. However, their efficacy predicting erythropoiesis-stimulating agents (ESAs) doses remains uncertain. This study aimed to evaluate the effectiveness of a contemporary artificial intelligence (AI) model prescribing ESA compared physicians HD Materials and Methods double-blinded control trial randomized participants into traditional doctor (Dr) AI groups. In Dr group, were...

Summary Background and objectives The risk factors for CKD in different age groups remain unknown. This community-based study aimed to identify the elderly nonelderly patients. Design, setting, participants, &amp; measurements A multistage sampling survey was conducted 2007 Kaohsiung County, an area with highest prevalence of dialysis world. defined as proteinuria at least microalbuminuric stage or estimated GFR (eGFR) &lt;60 ml/min per 1.73 m 2 . patient were identified (with 60 years a...

Abstract Glomerulosclerosis and tubulointerstitial fibrosis are associated with lower renal parenchymal elasticity. This study was designed to evaluate the predictive ability of elasticity in patients chronic kidney disease (CKD). 148 non-CKD 227 CKD were recruited. 145 (38.7%) female, 166 (73.1%) had diabetes, mean estimated glomerular filtration rate (eGFR) 33.9 ± 15.8 ml/min/1.73 m 2 median urinary protein-to-creatinine ratio (UPCR) 502 (122–1491) mg/g. Patients later stages values,...

Inadequate care of chronic kidney disease (CKD) is common and may be associated with adverse outcomes after dialysis. The nationwide pre-end-stage renal pay for performance program (P4P) has been implemented in Taiwan to improve quality CKD care. However, the effectiveness P4P improving pre-dialysis dialysis uncertain. We conducted a longitudinal cohort study. Patients who newly underwent long-term (≥3 mo) between 2007 2009 were identified from National Health Insurance Research Database....

Background: The National Health Insurance Administration in Taiwan initiated a nationwide pre-end-stage renal disease (ESRD) pay-for-performance (P4P) programme at the end of 2006 to improve quality care for chronic kidney (CKD) patients. This study aimed examine this programme's effect on patients' clinical outcomes and its cost-effectiveness among advanced CKD Methods: We conducted longitudinal observational matched cohort using two population-based datasets. major interests were incidence...

Abstract Diabetes duration, diabetic retinopathy (DR), and a diagnostic model have been proposed as clinical parameters favoring the presence of nephropathy (DN) in biopsied patients with kidney disease. DN, compared non-diabetic renal disease, had poorer outcomes. We tested whether these DN are associated outcomes non-biopsied patients. In this study, 1330 type 2 diabetes chronic disease stages 1–4 were included divided according to mellitus (DM) duration &gt;8 years, DR, or for DN. These...

Peritoneal dialysis (PD)-related infection is a serious complication of patients with PD. Refractory peritonitis may lead to failure PD, shift hemodialysis (HD) or death. Besides, microbiologic resistance increased worldwide that might impact the treatment choice for such infections. Investigating causative pathogens and risk factors PD-related infections in Taiwan was warranted.This retrospective study involving PD from 2007 2016 southern hospital. Patient characteristics, microbiological...

The association between body composition and gut microbiota in type 2 diabetes mellitus (DM) remains unknown.To elucidate the correlation of microbiota, we conducted a clinical study to enroll 179 patients with DM.Body lean tissue index (LTI) fat was measured by Body Composition Monitor.Eight pairs 16S rRNA gene primers specific Firmicutes, Bacteroidetes, Clostridium leptum group, Bacteroides, Bifidobacterium, Akkermansia muciniphila, Escherichia coli, Faecalibacterium prausnitzii were used...

Abstract Multidisciplinary care can improve the outcomes of chronic kidney disease (CKD), however contribution self-care behavior and knowledge about CKD is unclear. This study enrolled 454 participants with stages 1–5 not on dialysis. Structured questionnaires were used to evaluate knowledge. Rapid decline in renal function was defined as estimated filtration rate &gt; 3 ml/min per 1.73 m 2 /year within 1-year prior enrollment. The mean age all 65.8 ± 12.1 years 55.9% male. elderly had...

Chronic kidney disease is related to neurodegeneration and structural changes in the brain which might lead cognitive decline. The Fazekas scale used for assessing white matter hyperintensities (WMHs) was associated with poor performance. Therefore, this study investigated associations between mini-mental status examination (MMSE), Montreal assessment (MoCA), abilities screening instrument (CASI), patients under hemodialysis (HD).

Abstract Angiopoietins (Angpt) and vascular endothelial growth factor (VEGF) have been associated with cardiovascular disease. The study enrolled 270 pre-dialysis stage 3–5 CKD patients to assess the link between circulating Angpt2, Angpt1 VEGF-A subclinical measures of structure function. Serum markers angiogenesis were measured using commercial enzyme-linked immunosorbent assays. Cardiac function examined by echocardiography. Brachial-ankle pulse wave velocity (baPWV) was ankle-brachial...

Abstract A robust methodology is established to predict the critical bending radius of a flexible AMOLED. According methodology, display manufactured by same process could be reduced from 7 mm 4 modulating layer stack thickness.