A5024338074- Diabetes Treatment and Management
- Retinal Diseases and Treatments
- Retinoids in leukemia and cellular processes
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Helicobacter pylori-related gastroenterology studies
- Diabetes Management and Research
- Liver Disease Diagnosis and Treatment
- Diabetic Foot Ulcer Assessment and Management
- Peroxisome Proliferator-Activated Receptors
- Tuberculosis Research and Epidemiology
- Diabetes and associated disorders
- Oral microbiology and periodontitis research
- Dental Health and Care Utilization
- Chronic Kidney Disease and Diabetes
- Systemic Lupus Erythematosus Research
- Pancreatic function and diabetes
- Galectins and Cancer Biology
- Lipoproteins and Cardiovascular Health
- Non-Invasive Vital Sign Monitoring
- Eosinophilic Esophagitis
- SARS-CoV-2 and COVID-19 Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Nutritional Studies and Diet
- Parkinson's Disease Mechanisms and Treatments
Shanghai Children's Medical Center
2024-2025
Shanghai Jiao Tong University
2024-2025
Kaohsiung Medical University
2015-2024
Kaohsiung Medical University Chung-Ho Memorial Hospital
2015-2024
White Clinic
2023
Kaohsiung Municipal Ta-Tung Hospital
2015-2022
Texas Medical Center
2019
National Academy of Medicine
2014
Introduction Concerns have been raised regarding the potential association between proton pump inhibitor (PPI) use and dementia. Objective This study aimed to examine this in an Asian population. Methods Patients initiating PPI therapy January 1, 2000 December 31, 2003 without a prior history of dementia were identified from Taiwan’s National Health Insurance Research Database. The outcome interest was all-cause Cox regression models applied estimate hazard ratio (HR) cumulative dosage...
Patients with type 2 diabetes mellitus (DM) may experience chronic microvascular complications such as diabetic retinopathy (DR) and nephropathy (DN) during their lifetime. In clinical studies, serum uric acid concentration has been found to be associated DR DN. The goal of this study was evaluate the relationship between increases in level severity albuminuria Taiwanese patients DM. We recorded concentration, DR, by calculating urinary albumin-to-creatinine ratio (UACR) 385 multivariate...
Diabetes mellitus (DM) is a major risk factor for tuberculosis (TB). Evidence has linked the DM-related dysbiosis of gut microbiota to modifiable host immunity Mycobacterium infection. However, crosslinks between composition and immunological effects on development latent TB infection (LTBI) in DM patients remain uncertain.We prospectively obtained stool, blood samples, medical records from 130 with poorly-controlled (pDM), defined as ever having an HbA1c > 9.0% within previous 1 year. Among...
Abstract Background/Aims Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the best policies to control COVID-19 pandemic. The serological response vaccination in Taiwanese patients with different comorbidities elusive. Methods Uninfected subjects who received 3 doses mRNA vaccines (BNT162b2 [Pfizer-BioNTech, BNT] and mRNA-1273 [Moderna]), viral vector-based (ChAdOx1-S (AZD1222, AZ) or protein subunit (Medigen vaccine) were prospectively enrolled....
Abstract Glomerulosclerosis and tubulointerstitial fibrosis are associated with lower renal parenchymal elasticity. This study was designed to evaluate the predictive ability of elasticity in patients chronic kidney disease (CKD). 148 non-CKD 227 CKD were recruited. 145 (38.7%) female, 166 (73.1%) had diabetes, mean estimated glomerular filtration rate (eGFR) 33.9 ± 15.8 ml/min/1.73 m 2 median urinary protein-to-creatinine ratio (UPCR) 502 (122–1491) mg/g. Patients later stages values,...
Objective We studied the association between statin dosage and risk of Parkinson disease (PD) in diabetic patients Taiwan. Methods One million were randomly sampled from a National Health Insurance (NHI) database followed 2001 to 2008. Diabetic screened by diagnosis International Classification Diseases, Ninth Revision, Clinical Modification (ICD‐9‐CM) codes, was determined according NHI pharmacy database. PD diagnosed on basis ICD‐9‐CM codes anti‐Parkinson medication use. Statin users...
Patients with diabetes mellitus can experience hyperglycemia, which affects brain function and produces cognitive impairment or neurodegeneration. Neuroinflammation is an important cause of dysfunction. Sodium-glucose cotransporter 2 (SGLT2) inhibitors are antihyperglycemic agents that reportedly possess anti-inflammatory properties may produce beneficial effects. We hypothesized SGLT2 alleviate hyperglycemia-related inflammation in immune cells. Cultured BV-2 microglia were exposed to high...
Background: It is well known that diabetes mellitus impairs immunity and therefore an independent risk factor for tuberculosis. However, the influence of associated metabolic factors, such as hypertension, dyslipidemia gout has yet to be confirmed. This study aimed investigate whether strong association between tuberculosis from hypertension dyslipidemia, its treatment in elderly Taiwanese patients. Methods: A total 27,958 patients aged more than 65 years were identified National Health...
Patients with diabetes have a higher risk of developing chronic complications and cause huge burden to the public health care system as well on patients their families. We studied these diabetic about kidney, eye peripheral vascular diseases understand prevalence distributions in national survey.We analyzed using National-Health-Insurance claims filed from 2005 2014. used this database evaluate developments eye, according International-Classification-of-Diseases, Ninth Revision clinical...
Background and purpose The pharmacologic effects of pioglitazone on the incidence Parkinson disease (PD) are not clear. No study has examined interaction between statin treatment prevention PD. This analyzed associations pioglitazone, statins, PD in patients with diabetes mellitus (DM) Taiwan. Methods We used National Health Insurance database from 1996 to 2013. DM were diagnosed according International Classification Diseases , Ninth Revision Clinical Modification codes. propensity...
Abstract Background Poor control of diabetes mellitus (DM) increases active tuberculosis (TB) risk. Understanding risk factors for latent TB infection (LTBI) in this population and intervention completion rates is crucial policy making. Methods Under a collaborative multidisciplinary team consisting public health professionals, endocrinologists, pulmonologists, patients aged >45 years with poorly controlled DM (pDM), defined as having glycated hemoglobin level ≥9% within the preceding...
Abstract Obesity can augment insulin resistance (IR), leading to increased risk of diabetes and heart disease. Leptin, ghrelin, various fatty acids present in the cell membrane may modulate IR. In this study, we aimed investigate impact weight loss on IR, serum leptin/ghrelin levels, erythrocyte acids, studied associations between changes these variables. A total 35 obese (body mass index ≥ 27) adults participated a program for 3 months. IR was assessed using homeostasis model assessment...
Although α-glucosidase inhibitors (AGIs) have been shown to reduce the risk of myocardial infarction in patients with impaired glucose tolerance, cardiovascular benefits AGIs those type 2 diabetes (T2D) remains unclear. We compared clinical outcomes adding acarbose vs sulfonylureas metformin therapy T2D. The study population was drawn from database Diabetes Pay-for-Performance program Taiwan. Sulfonylureas and were prescribed 196,143 14,306 T2D, respectively, 2004 2015, who had treated...
Background: Diabetes mellitus is known to exacerbate bacterial infection, but its effect on the severity of viral infection has not been well studied. The thrombocytopenia an indicator dengue virus infection. We investigated whether diabetes associated with in dengue-infected patients. Methods: studied clinical characteristics 644 patients at a university hospital during epidemic 1 June 2002 31 December Taiwan. Platelet counts and biochemical data were compared between without diabetes....