A5003401750- Pregnancy and preeclampsia studies
- Cellular transport and secretion
- Natural Compounds in Disease Treatment
- Hippo pathway signaling and YAP/TAZ
- Gestational Diabetes Research and Management
- Hormonal Regulation and Hypertension
- Virus-based gene therapy research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Microtubule and mitosis dynamics
- Cardiovascular Issues in Pregnancy
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Research on Leishmaniasis Studies
- Liver Disease Diagnosis and Treatment
- Nutrition and Health in Aging
- Birth, Development, and Health
- Fetal and Pediatric Neurological Disorders
- Plant Molecular Biology Research
- Viral Infectious Diseases and Gene Expression in Insects
- Prenatal Screening and Diagnostics
- Liver Disease and Transplantation
- Phytochemistry and Bioactivity Studies
- Ginkgo biloba and Cashew Applications
- Lipid metabolism and biosynthesis
- Herpesvirus Infections and Treatments
- Neurological Complications and Syndromes
National Taiwan University
2013-2020
National Taiwan University Hospital
2012
Kaohsiung Medical University
1998-2011
Lanzhou Veterinary Research Institute
2008
Chang Gung University
2005
Abstract A large number of residents on the southwest coast Taiwan suffer from an endemic peripheral vascular disease called blackfoot disease. Although etiology has been investigated since 1958, cause remains unknown. Certain substances contained in artesian well water have implicated as causal factors, including arsenic predominant element. Data this study demonstrated that collected regions there was a marked increase total concentrations, with species being inorganic arsenical compounds....
Abstract O‐linked N ‐acetylglucosamine (O‐GlcNAc) protein modification has been implicated in the regulation of signaling pathways, cell function, and gene expression. Glutamine:fructose‐6‐phosphate amidotransferase‐1 (GFAT‐1) is rate‐limiting enzyme hexosamine biosynthetic pathway (HBP), which generates sugar nucleotide UDP‐GlcNAc, where this acts as donor for O‐GlcNAc modification. In study, we determined whether GFAT‐1 regulates adipogenesis adipocytes. 3T3‐L1 preadipocytes were...
ABSTRACT Osteoarthritis (OA) is a degenerative joint disease involving combination of cartilage degradation and inflammation. EGb761, standardized extract Ginkgo biloba leaves, holds an anti‐inflammatory potency. Here, we determined whether EGb761 could inhibit lipopolysaccharide (LPS)‐ IL‐1β‐induced inflammatory responses in human articular chondrocytes apply the chondroprotection OA rats. We found that LPS markedly induced productions PGE2 NO protein expressions COX‐2 iNOS chondrocytes....
During development, certain Drosophila sensory neurons undergo dendrite pruning that selectively eliminates their dendrites but leaves the axons intact. How these regulate activity in remains unknown. Here, we identify a coiled-coil protein Spindle-F (Spn-F) is required for neurons. Spn-F acts downstream of IKK-related kinase Ik2 same pathway pruning. exhibits punctate pattern larval neurons, whereas puncta become redistributed pupal step essential The redistribution from requires...
Neuronal pruning is a commonly observed phenomenon for the developing nervous systems to ensure precise wiring of neural circuits. The function Ik2 kinase and its downstream mediator, Spindle-F (Spn-F), are essential dendrite Drosophila sensory neurons during development. However, little known about how Ik2/Spn-F signaling transduced in ultimately results pruning. Our genetic analyses rescue experiments demonstrated that small GTPase Rab11, especially active GTP-bound form, required We also...