A5018177875- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Parathyroid Disorders and Treatments
- Gut microbiota and health
- Angiogenesis and VEGF in Cancer
- Lipid metabolism and disorders
- Renal and Vascular Pathologies
- Dementia and Cognitive Impairment Research
- Erythropoietin and Anemia Treatment
- Pharmacological Effects and Toxicity Studies
- Neurological and metabolic disorders
- Blood Pressure and Hypertension Studies
- Diet and metabolism studies
- Cardiovascular Health and Disease Prevention
- Advanced Glycation End Products research
- Clostridium difficile and Clostridium perfringens research
- Renal and related cancers
- Genetic and Kidney Cyst Diseases
- Birth, Development, and Health
- Heart Failure Treatment and Management
- Mobile Health and mHealth Applications
- Drug-Induced Adverse Reactions
- Nitric Oxide and Endothelin Effects
- MicroRNA in disease regulation
Kaohsiung Medical University
2015-2024
Kaohsiung Medical University Chung-Ho Memorial Hospital
2015-2024
Bridge University
2016
Pediatric Nephrology of Alabama
2014
Institute of Clinical Research
2014
New York Medical College
2007-2010
Renal Research Institute
2007-2010
National University of Kaohsiung
2009
Zuoying Armed Forces General Hospital
2005
Kaohsiung Armed Forces General Hospital
2005
Background and objectives Fluid overload is a common characteristic associated with renal progression in CKD. Additionally, fluid an independent predictor of all-cause or cardiovascular mortality patients on dialysis, but its influence not dialysis uncertain. The aim the study was to assess relationship between severity status clinical outcomes advanced CKD cohort. Design, setting, participants, & measurements In total, 478 predialysis stages 4 5 integrated care program were enrolled from...
Hyperuricemia is an independent risk factor for mortality, cardiovascular disease, and renal disease in general population. However, the relationship between hyperuricemia with clinical outcomes CKD remains controversial.The study investigated association uric acid all-cause events, replacement therapy, rapid progression (the slope of estimated GFR was less than -6 ml/min per 1.73 m(2)/y) 3303 stages 3-5 patients that were integrated care system one medical center regional hospital southern...
Dyslipidemia is highly prevalent in patients with chronic kidney disease (CKD) and the relationship between dyslipidemia renal outcomes moderate to advanced CKD remains controversial. Hence, our objective determine whether independently associated rapid progression replacement therapy (RRT) patients. The study analyzed association lipid profile, RRT, (estimated glomerular filtration rate [eGFR] slope <-6 ml/min/1.73 m(2)/yr) 3303 stages 3 5 CKD. During a median 2.8-year follow-up, 1080...
Abstract Background Diabetic nephropathy (DN) is an increasing threat to human health and regarded be the leading cause of end-stage renal disease worldwide. Exosomes delivery may play a key role in cross-talk among kidney cells progression DN. However, mechanisms underlying exosomes DN remain unclear. Methods The cross-disciplinary study, including vivo, vitro, studies was conducted explore between proximal tubular epithelial (PTECs) mesangial (MCs) We purified exosome from PTECs treated...
Abstract Diabetic kidney disease (DKD) is the leading cause of end-stage disease, resulting in a huge socio-economic impact. Kidney highly complex organ and pathogenesis underlying organization involves cell-to-cell interaction within heterogeneous milieu. Advanced single-cell RNA sequencing (scRNA-seq) could reveal architecture with microenvironment early DKD. We used scRNA-seq to investigate changes db/m mice db/db at 14th week. Uniform Manifold Approximation Projection were applied...
Background Estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease (MDRD) study or Chronic Kidney Epidemiology Collaboration (CKD-EPI) equations may not be accurate for Asians; thus, we developed modified eGFR Taiwanese adults. Methods This cross-sectional compared equations, MDRD study, and CKD-EPI with inulin clearance (Cin). A total 695 adults including 259 healthy volunteers 436 CKD patients were recruited. Participants from Kaohsiung Medical...
Diabetic nephropathy (DN) is an increasing threat to human health and regarded as important public issue. The pathophysiologic mechanisms of DN are complicated. initiating molecular events triggering the loss function in mesangial cells (MCs) not well known. In this cross-disciplinary study, transcriptome analysis high glucose (HG)-treated mouse MCs (MMCs) using next-generation sequencing systematic bioinformatics analyses indicated that miR-15b-5p its downstream target B cell lymphoma 2...
In the 2002 dengue outbreak in Taiwan, some fatal cases had underlying disease of renal failure (RF). Physicians faced difficulty diagnosis and treatment these patients; however, impacts RF on clinical presentations outcomes infection have not been reported previously.A retrospective review was conducted medical records, presentations, laboratory findings, diseases for all a center. Characteristics dengue-infected patients with without were compared.From January through 2003, 519 enrolled,...
We aimed to investigate the potential relationship between alarmins [acting via Toll-like receptor-4 (TLR4)], uric acid (UA), and high-mobility group box-1 protein (HMGB1) during acute kidney injury. UA, which is significantly increased in circulation following renal ischemia-reperfusion injury (IRI), was used both vitro vivo as an early response-signaling molecule determine its ability induce secretion of HMGB1 from endothelial cells. Treatment human umbilical vein cells (HUVEC) with UA...
Patients with chronic kidney disease (CKD) are more readily prone to have impaired physical activity than the general population. The aim of this study is examine relationship between and adverse clinical outcomes quality life (QOL) in CKD. One hundred sixty-one patients CKD stages 1-5 was enrolled from February 2013 September followed up until June 2016. Physical measured using high handgrip strength, 30-second chair stand, 2-minute step. QOL assessed Taiwan version World Health...
Abstract Patients with chronic kidney disease have a greater risk of cognitive impairment. Cerebral uremic solute accumulation causes encephalopathy; however, the association protein-bound toxins on function remains unclear. The present study aimed to investigate two toxins, namely indoxyl sulfate (IS) and p-cresyl (PCS), in patients receiving hemodialysis (HD) for at least 90 days. Circulating free form IS PCS were quantified by liquid chromatography/mass spectrometry. Mini-Mental State...
Uremic toxins accumulated in chronic kidney disease (CKD) increases the risk of cognitive impairment. Indoxyl sulfate (IS) is a well-known protein-bound uremic toxin that correlated with several systemic diseases, but no studies on human brain cells are available. We investigated effect IS primary astrocytes through next-generation sequencing and cell experiment confirmation to explore mechanism IS-associated damage. Total RNAs extracted from IS-treated control were evaluated by performing...
Abstract Background/Aims Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the best policies to control COVID-19 pandemic. The serological response vaccination in Taiwanese patients with different comorbidities elusive. Methods Uninfected subjects who received 3 doses mRNA vaccines (BNT162b2 [Pfizer-BioNTech, BNT] and mRNA-1273 [Moderna]), viral vector-based (ChAdOx1-S (AZD1222, AZ) or protein subunit (Medigen vaccine) were prospectively enrolled....
Peritoneal dialysis (PD)-related infection is a serious complication of patients with PD. Refractory peritonitis may lead to failure PD, shift hemodialysis (HD) or death. Besides, microbiologic resistance increased worldwide that might impact the treatment choice for such infections. Investigating causative pathogens and risk factors PD-related infections in Taiwan was warranted.This retrospective study involving PD from 2007 2016 southern hospital. Patient characteristics, microbiological...
The association between body composition and gut microbiota in type 2 diabetes mellitus (DM) remains unknown.To elucidate the correlation of microbiota, we conducted a clinical study to enroll 179 patients with DM.Body lean tissue index (LTI) fat was measured by Body Composition Monitor.Eight pairs 16S rRNA gene primers specific Firmicutes, Bacteroidetes, Clostridium leptum group, Bacteroides, Bifidobacterium, Akkermansia muciniphila, Escherichia coli, Faecalibacterium prausnitzii were used...
Chronic kidney disease is related to neurodegeneration and structural changes in the brain which might lead cognitive decline. The Fazekas scale used for assessing white matter hyperintensities (WMHs) was associated with poor performance. Therefore, this study investigated associations between mini-mental status examination (MMSE), Montreal assessment (MoCA), abilities screening instrument (CASI), patients under hemodialysis (HD).
Recruitment of various stem and progenitor cells is crucial for the regeneration an injured organ. Levels uric acid, one prototypical "alarm signals," surge after ischemia-reperfusion injury. Exogenous acid rapidly mobilizes endothelial hematopoietic protects kidney from ischemia. The relatively fast responses to suggest that preformed second messengers may be released a storage pool. Here, it reported monosodium urate (MSU) results in exocytosis Weibel-Palade bodies vitro vivo, leading...
<i>Background:</i> Skin lesion is the most frequent manifestation of adverse drug reactions. Drug-induced cutaneous hypersensitivity and drug-induced acute interstitial nephritis might share a similar mechanism involving drug-specific T cells. We thus investigated renal outcome Stevens-Johnson syndrome (SJS) toxic epidermal necrolysis (TEN), severe hypersensitivity, hypothesize that skin detachment in SJS/TEN be associated with failure (ARF). <i>Methods:</i> 234...