A5103150480- Intraoperative Neuromonitoring and Anesthetic Effects
- Spinal Fractures and Fixation Techniques
- Intracranial Aneurysms: Treatment and Complications
- Meningioma and schwannoma management
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Pain Management
- Lipid Membrane Structure and Behavior
- Lipid metabolism and biosynthesis
- RNA Interference and Gene Delivery
- Transcranial Magnetic Stimulation Studies
- Facial Nerve Paralysis Treatment and Research
- Cholesterol and Lipid Metabolism
- EEG and Brain-Computer Interfaces
- Muscle metabolism and nutrition
- Cancer, Lipids, and Metabolism
- Cerebrovascular and Carotid Artery Diseases
- Dialysis and Renal Disease Management
- Cardiac, Anesthesia and Surgical Outcomes
- Research on Leishmaniasis Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Drug Transport and Resistance Mechanisms
- Metabolism and Genetic Disorders
- Liver Disease Diagnosis and Treatment
- Trigeminal Neuralgia and Treatments
- Spine and Intervertebral Disc Pathology
Shenyang Pharmaceutical University
2025
University of California, San Francisco
2013-2024
Neurological Surgery
2008
Menlo School
1989-1992
University of California, Berkeley
1982
National Cancer Institute
1980
UCLA Medical Center
1978
The uptake and catabolism of lamellar complexes rat 125I-labeled apolipoprotein (apo) E with egg lecithin were increased severalfold in perfused livers rats given large amounts 17 alpha-ethynylestradiol for 5 days. Estrogen-stimulated human apo that contained all the major normally occurring "isoforms" protein (apo E-1, E-2, E-3, E-4) was comparable to E. By contrast, containing from individuals familial dysbetalipoproteinemia (dys beta LP; characterized by a lack E-3 stimualted much smaller...
A simple, rapid, and almost quantitative technique is described for the preparation of 1-40 ml homogeneous unilamellar liposomes from dilute or concentrated aqueous suspensions egg phosphatidylcholine.Aqueous lipid are placed within chamber a French pressure cell at room temperature rapidly extruded 20,000 psi through small orifice.A single pass transforms more than 70% into population single-wall bilayer vesicles; 90% transformed by recycling cell.About 95% these range between 150-300 8, in...
The effect of rat whole blood plasma, serum, serum lipoproteins, and apolipoproteins on the stability unilamellar liposomes prepared with French pressure cell was evaluated by measuring release entrapped carboxyfluorescein electron microscopy.In absence components, dye escaped very slowly (hours) from egg phosphatidylcholine phosphatidylcholine-cholesterol (43 mol '% cholesterol) vesicles without apparent change in liposomal structure.This slow both temperature-and size-dependent.Serum some...
The pharmacokinetics and tissue distribution of two amphotericin B dosage forms were compared in rats. A novel lipid-based colloidal delivery system for (Amphotericin Colloidal Dispersion [ABCD]) which reduces the toxicity animals was with a conventional micellar formulation. Male Sprague-Dawley rats received single intravenous injection 1.0 mg ABCD, 5.0 or per kg. Plasma samples obtained at 0.5 to 96 h after dosing analyzed by high-pressure liquid chromatography. Animals receiving ABCD...
The safety, pharmacokinetics, and distribution in tissue of an amphotericin B (AmB)-cholesteryl sulfate colloidal dispersion (ABCD) were compared with those micellar B-deoxycholate (m-AmB). Dogs received 14 daily injections ABCD (0.6 to 10 mg/kg body weight per day) or m-AmB mg/kg/day). Safety was evaluated by monitoring weight, hematology, clinical chemistry, urinalysis during the study microscopic examination tissues at time necropsy (day 16). AmB concentrations plasma measured some groups...
Liposomes, as an efficient nanoscale drug carrier, hold significant advantages in antitumor therapy. The unique bilayer structure of phospholipids enables liposomes to simultaneously encapsulate both lipophilic and hydrophilic drugs, while also possessing good biocompatibility low immunogenicity. Through passive or active targeting mechanisms, can precisely deliver drugs tumor tissues, thereby significantly enhancing therapeutic efficacy reducing systemic adverse reactions. This paper...
Triglyceride-rich very low density lipoproteins (VLDL) are the major lipoprotein in perfusates of normal guinea pig livers.Their component apoprotein B is mainly B-100 together with some B-95.This actively synthesized, as C apoproteins and small amounts E. Only trace intermediate (IDL, 1.015 < d 1.05 g/ml) found perfusates, but appreciable (LDL, 1.10 accumulate.These LDL not newly rather appear to be gradually washed out liver.High (HDL, 1.21 both discoidal spheroidal, also accumulate, which...
The American Society of Neurophysiological Monitoring (ASNM) was founded in 1989 as the Evoked Potential Monitoring. From beginning, has been made up physicians, doctoral degree holders, Technologists, and all those interested furthering profession. changed its name to ASNM held first Annual Meeting 1990. It remains largest worldwide organization dedicated solely scientifically-based advancement intraoperative neurophysiology. primary goal is assure quality patient care during procedures...
We hypothesized that the addition of dexmedetomidine in a clinically relevant dose to propofol-remifentanil anesthesia regimen does not exert an adverse effect on motor-evoked potentials (MEP) and somatosensory-evoked (SSEP) adult patients undergoing thoracic spinal cord tumor resection. Seventy-one were randomized into three groups. Propofol group (n = 25): regimenand dosage was adjusted maintain bispectral index (BIS) between 40 50. DP 23): Dexmedetomidine (0.5 μg/kg loading infused over...
Uniformly fatty livers from orotic acid-fed rats secreted almost no very low density lipoproteins (VLDL) but normal amounts of nascent high (HDL) accumulated in perfusates.When 1ecithin:cholesterol acyltransferase (LCAT) was inhibited, HDL were uniformly discoidal and lacked cholesteryl esters.Lipid apoprotein compositions similar whether LCAT inhibited or not.Apolipoprotein B-100 not detected perfusates livers, small apolipoprotein B-48 present HDL2 fractions.Nascent seen Golgi...
The effect of phenobarbital on the level rat liver apolipoprotein A-I (apo-A-I) mRNA was studied. Poly(A+)-RNA isolated from livers control or phenobarbital-treated rats translated in vitro rabbit reticulocyte lysate system and immunoprecipitated with antiserum against apo-A-I. immunoprecipitate analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. translational activity apo-A-I estimated incorporation [35S]methionine into band. It found to be elevated 4-fold 16 hr after...
We have characterized and quantified the two major plasma apoproteins of high density lipoproteins (HDL), apolipoproteins A-I (apoA-I) E (apoE), guinea pigs fed standard chow (normal) or supplemented with 1% cholesterol (cholesterol-fed).ApoA-I isolated from HDL normal pig exists in six polymorphic forms .A similar isoform pattern this apoprotein was present nascent perfused livers cholesterol-fed animals.This contains cysteine isoleucine is slightly different overall amino acid composition...
Motor evoked potentials (MEPs) are commonly used during surgery for spinal cord tumor resection. However, it can be difficult to record reliable MEPs from the muscles of lower extremities in patients with preoperative weakness due compression. In this study, motor function patients' and their association intraoperative MEP recording were compared.Patients undergoing thoracic resection studied. Patients' was checked immediately before surgical procedure. responses recorded tibialis anterior...
To analyze optimal placement of recording-needle electrodes surrounding the eye and lip for facial nerve monitoring by identifying maximum compound muscle action potential (CMAP) recorded electrode pairs different spatial configurations.Prospective clinical trial.Ambulatory surgery at a tertiary care center.Thirty adults undergoing chronic ear such as tympanoplasty, mastoidectomy, ossicular chain reconstruction, stapedectomy, cochlear implantation.Facial monitoring.Suprathreshold (threshold...
<b><i>Background/Aims:</i></b> A major goal of intracranial surgery is to maximize resection while minimizing neurological morbidity, particularly motor dysfunction. Direct cortical stimulation (DCS) a common intraoperative adjunct used identify functional cortex. In this study, we report on the safety/efficacy short pulse train DCS (direct motor-evoked potential, dcMEP) for mapping and monitoring during surgery. <b><i>Methods:</i></b>...
A series of positively charged phospholipid and cholesterol derivatives was synthesized evaluated as membrane components for liposomes. Small unilamellar liposomes containing up to 40 mole% the synthetic lipids were prepared by sonication. Selected liposome preparations these lipid materials found be noncytotoxic in vitro using a cell growth inhibition assay, whereas more classic (stearylamine cetyltrimethylammonium bromide) showed considerable cytotoxicity. Using an unanesthetized rabbit...