A5026859909- Pain Mechanisms and Treatments
- Zebrafish Biomedical Research Applications
- Cognitive and developmental aspects of mathematical skills
- Genetics and Neurodevelopmental Disorders
- Stress Responses and Cortisol
- Mathematics Education and Teaching Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion channel regulation and function
- Neuroendocrine regulation and behavior
- Ion Channels and Receptors
- Autism Spectrum Disorder Research
- Telomeres, Telomerase, and Senescence
- Exercise and Physiological Responses
- Trigeminal Neuralgia and Treatments
- Spaceflight effects on biology
- Genetics, Aging, and Longevity in Model Organisms
- Nuclear Receptors and Signaling
- Erythrocyte Function and Pathophysiology
- Neurogenesis and neuroplasticity mechanisms
- Neuropeptides and Animal Physiology
- Neuroscience of respiration and sleep
- Hereditary Neurological Disorders
- Regulation of Appetite and Obesity
- Migraine and Headache Studies
- Botulinum Toxin and Related Neurological Disorders
Universitat de València
2021-2025
Universidad de Burgos
2024
Imperial College London
2014-2022
Queen Mary University of London
2019-2022
UK Dementia Research Institute
2021-2022
Chelsea and Westminster Hospital
2014-2020
<title>Abstract</title> Rett Syndrome (RTT), a neurodevelopmental disorder predominantly affecting females, is characterised by evolving symptoms impacting motor and sensory domains. Herein, we present study of longitudinal analyses, from 2- to 6-month age, <italic>Mecp</italic>2 heterozygous (<italic>Mecp2</italic>-het) female mice comprehensively explore pain perception in RTT. Interestingly, found significant variability the timing progression symptom onset among...
BAZ1B is a ubiquitously expressed nuclear protein with roles in chromatin remodeling, DNA replication and repair, transcription. Reduced
A sense of non-symbolic numerical magnitudes is widespread in the animal kingdom and has been documented adult zebrafish. Here, we investigated ontogeny this ability using a group size preference (GSP) task juvenile Fish showed GSP from 21 days post-fertilization reliably chose larger when presented with discriminations between 1 versus 3, 2 5 3 conspecifics but not 4 conspecifics. When ratio number each was maintained at : 2, fish could discriminate individuals 6, again, given choice...
Transcriptional changes in superficial spinal dorsal horn neurons (SSDHN) are essential the development and maintenance of prolonged pain. Epigenetic mechanisms including post-translational modifications histones pivotal regulating transcription. Here, we report that phosphorylation serine 10 (S10) histone 3 (H3) specifically occurs a group rat SSDHN following activation nociceptive primary sensory by burn injury, capsaicin application or sustained electrical nerve fibres. In contrast, brief...
Elevation of intracellular Ca2+ concentration induces the synthesis N-arachydonoylethanolamine (anandamide) in a subpopulation primary sensory neurons. N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is only known enzyme that synthesizes anandamide -dependent manner. NAPE-PLD mRNA as well anandamide's main targets, excitatory transient receptor potential vanilloid type 1 ion channel (TRPV1), inhibitory cannabinoid (CB1) receptor, and anandamide-hydrolyzing fatty acid amide...
Individual differences in personality are associated with variation healthy aging. Health behaviours often cited as the likely explanation for this association; however, an underlying biological mechanism may also exist. Accelerated leukocyte telomere shortening is implicated multiple age-related diseases and chronic activation of hypothalamus-pituitary-adrenal (HPA) axis, providing a link between stress-related adverse health outcomes. However, effects HPA axis tissue specific. Thus, length...
Controlling pain in burn-injured patients poses a major clinical challenge. Recent findings suggest that reducing the activity of voltage-gated sodium channel Nav1.7 primary sensory neurons could provide improved control patients. Here, we report partial thickness scalding-type burn injury on rat paw upregulates expression 3 h following injury. The also induces upregulation phosphorylated cyclic adenosine monophosphate response element-binding protein (p-CREB), marker for nociceptive...
Number sense, the ability to discriminate quantity of objects, is crucial for survival. To understand how neurons work together and develop mediate number we used two-photon fluorescence light sheet microscopy capture activity individual throughout brain larval
Burn injury is a pathology underpinned by progressive and aberrant inflammation. It major clinical challenge to survival quality of life. Although the complex local disseminating pathological processes burn ultimately stem from tissue damage, date relatively few studies have attempted characterise inflammatory mediator profile. Here, cytokine content associated transcriptional changes were measured in rat skin for three hours immediately following induction scald-type (60°C, 2 min) model....
Ankyrin repeat and kinase domain containing 1 (ANKK1) is a member of the receptor-interacting protein serine/threonine family, known to be involved in cell proliferation, differentiation activation transcription factors. Genetic variation within ANKK1 locus suggested play role vulnerability addictions. However, mechanism action still poorly understood. It has been that may affect development and/or functioning dopaminergic pathways. To test this hypothesis, we generated CRISPR-Cas9 loss...
Background/Aims: The primary cilium is a nanoscale membrane protrusion believed to act as mechano-chemical sensor in range of different cell types.Disruptions its structure and signalling have been linked number medical conditions, referred ciliopathies, but remain poorly understood due lack techniques capable investigating signal transduction cilia at nanoscale.Here we set out use latest advances nanopipette technology address the question ion channel distribution along cilium.Methods: We...
The involvement of hypothalamic nuclei in the pathophysiology migraine and trigeminal autonomic cephalalgias has been suggested for some time, with dopaminergic mechanisms proposed to play a prominent role. A11 nucleus is, date, only found provide dopamine-mediated inhibitory effect on nociceptive transmission trigeminocervical complex.
Domestication is associated with both morphological and behavioural phenotypic changes that differentiate domesticated species from their wild counterparts. Some of the traits are those purposely targeted by selection process, whilst others co-occur as a result selection. The combination referred to domestication syndrome shared characteristics has given rise neural crest (NCDS) hypothesis. According this hypothesis, consequence towards animals mild underdevelopment crest. A similar...
The methyl-CpG binding protein 2 gene (MECP2) encodes an epigenetic transcriptional regulator implicated in neuronal plasticity. Loss-of-function mutations this are the primary cause of Rett syndrome and, to a lesser degree, other neurodevelopmental disorders. Recently, we demonstrated that both Mecp2 haploinsuficiency and mild early life stress decrease anxiety-like behaviours activation brain areas controlling these responses adolescent female mice. Here, extend work males by using...