A5083774590- Pain Mechanisms and Treatments
- Botany and Plant Ecology Studies
- Neuroscience and Neuropharmacology Research
- Bryophyte Studies and Records
- Peatlands and Wetlands Ecology
- Lichen and fungal ecology
- Neuropeptides and Animal Physiology
- Ion channel regulation and function
- Musculoskeletal pain and rehabilitation
- Neural dynamics and brain function
- Neurobiology and Insect Physiology Research
- Zebrafish Biomedical Research Applications
- Nerve injury and regeneration
- Hungarian Social, Economic and Educational Studies
- Myofascial pain diagnosis and treatment
- Sleep and Wakefulness Research
- Groundwater flow and contamination studies
- Neuroscience and Neural Engineering
- Healthcare and Venom Research
- Marine and environmental studies
- Memory and Neural Mechanisms
- Cell Image Analysis Techniques
- Reservoir Engineering and Simulation Methods
- Migraine and Headache Studies
- Hereditary Neurological Disorders
University of Debrecen
2014-2024
Eszterhazy Karoly Catholic University
2015-2024
University of Szeged
1992-2024
University of Miskolc
2023
Institute of Botany
2020
Universidade do Porto
2008-2015
Hungarian Academy of Sciences
2006-2015
Public Health Dayton & Montgomery County
2015
Institut de Biologie Moléculaire et Cellulaire
2014
Instituto de Biologia Molecular e Celular
2011-2014
1 Inhibitory postsynaptic currents (IPSCs) evoked in CA1 pyramidal cells (n= 46) by identified interneurones 43) located str. oriens were recorded order to compare their functional properties and determine the effect of synapse location on apparent IPSC kinetics as using somatic voltage clamp at -70 mV nearly symmetrical [Cl−]. 2 Five types visualised presynaptic interneurone, oriens-lacunosum moleculare (O-LMC), basket (BC), axo-axonic (AAC), bistratified (BiC) oriens-bistratified (O-BiC)...
This is the first report of Anastrophyllum michauxii from Vologda Region.It a montane subcircumpolar liverwort species.The species known in several European countries (Austria, Bulgaria, France, Czech Republic and Slovakia, Germany, Hungary, former Yugoslavia, Italy, Romania, Poland, Finland, Sweden, Norway), Asia (China, Japan) few sites North America (Damsholt, 2002;Schumacker & Va ´n ˇa, 2005).In Russia, A. has been found mountainous areas: Northern Middle Urals, Caucasus, Stanovoye...
Presynaptic metabotropic glutamate receptors (mGluRs) show a highly selective expression and subcellular location in nerve terminals modulating neurotransmitter release. We have demonstrated that alternatively spliced variants of mGluR8, mGluR8a mGluR8b, an overlapping distribution the hippocampus, besides perforant path terminals, they are expressed presynaptic active zone boutons making synapses selectively with several types GABAergic interneurons, primarily stratum oriens. Boutons...
Our systematic analysis of anion channels and transporters in idiopathic pulmonary arterial hypertension (IPAH) showed marked upregulation the Cl − channel TMEM16A gene. We hypothesised that overexpression might represent a novel vicious circle molecular pathways causing (PAH). investigated healthy donor lungs (n=40) recipient with IPAH (n=38) for expression transporter genes small arteries artery smooth muscle cells (PASMCs). In IPAH, was strongly upregulated patch-clamp recordings...
Referred pain is a phenomenon of feeling at site other than the painful stimulus origin. It arises from pathological mixing nociceptive processing pathways for visceral and somatic inputs. Despite numerous studies based on unit recordings spinal supraspinal neurons, exact mechanism this within central nervous system are not known. Here, we selectively recorded lamina I using visually guided patch-clamp technique, in thoracic cord preparation with preserved intercostal (somatic) splanchnic...
Presynaptic inhibition of primary muscle spindle (group Ia) afferent terminals in motor nuclei the spinal cord plays an important role regulating output and is produced by a population GABAergic axon known as P boutons. Despite extensive investigation, cells that mediate this control have not yet been identified. In work, we use immunocytochemistry with confocal microscopy EM to demonstrate boutons can be distinguished from other ventral horn rat mouse their high level glutamic acid...
1. Anastrophyllum hellerianum (Lindenb.) R.M.Schust.Contributors: D. A. Callaghan and M. LuthPortugal: 1 km south of Mata da Albergaria, Peneda-Geres National Park, Braga District, 41°45′38″N, 8°8′...
Ionic conductances underlying excitability in tonically firing neurons (TFNs) from substantia gelatinosa (SG) were studied by the patch-clamp method rat spinal cord slices. Ca 2+ -dependent K + (K CA ) conductance sensitive to apamin was found prolong interspike intervals and stabilize evoked a sustained membrane depolarization. Suppression of currents, however, did not abolish basic pattern tonic firing, indicating that it generated voltage-gated Na currents. channels further analyzed...
Retinoids are morphogens and have been implicated in cell fate commitment of embryonic stem cells (ESCs) to neurons. Their effects mediated by RAR RXR nuclear receptors. However, transcriptional cofactors required for gene-specific retinoid signaling not known. Here we show that protein arginine methyl transferase (PRMT) 1 8 key roles determining regulated gene expression cellular specification a multistage neuronal differentiation model murine ESCs. PRMT1 acts as selective modulator,...
Spinal lamina I and the lateral spinal nucleus (LSN) receive integrate nociceptive primary afferent inputs to project through diverse ascending pathways. The pattern of supply individual LSN neurons different segmental dorsal roots is poorly understood. Therefore, we recorded responses in segments L4 L3 stimulation six ipsilateral (L1–L6). were viewed overlying white matter isolated cord preparation using oblique infrared LED illumination technique. Orientation myelinated fibers was used as...
Feddes Repertorium 87: 188. 1976 [Euosmolejeunea cedercreutzii H.Buch & Perss., Commentationes Biologicae 8 (7): 9. 1941]. MADEIRA: on bark of moribund Erica, north side Pico Topeiro, to east Encumeada, ca 1150 m a.s.l., April 2007, leg. T.L. Blockeel no. 36/102 (LISU, duplicate in Hb. Blockeel). AZORES: Terceira: damp crevice lava field, Misterio Negro, 10 km N.W. Angra do Heroismo, UTM 75–87-, 650 15 July 1994, J.W. Bates R. Gabriel, 3498 (Hb. Bates); Laurus steep forest, Terra Brava,...
Spinal lamina I is a key area for relaying and integrating information from nociceptive primary afferents with various other sources of inputs. Although projection neurons have been intensively studied, much less attention has given to local-circuit (LCNs), which form the majority neuronal population. In this work infrared light-emitting diode oblique illumination technique was used visualize label LCNs, allowing reconstruction analysis their dendritic extensive axonal trees. We show that...
Spontaneous succession is increasingly involved in grassland restoration, because it offers a cost‐effective solution compared to technical reclamation methods. This topic especially important nowadays, as large areas of marginal croplands are being abandoned on poor soils Central and Eastern Europe, which possibility for the spontaneous recovery typical target grasslands. Studying vegetation composition, aboveground biomass, seed bank old fields different age calcareous sand grasslands...
Our earlier findings revealed that interleukin-1 receptor type-1 (IL-1R1) was overexpressed in spinal neurons, and IL-1R1-deficient mice showed significant attenuation of thermal mechanical allodynia during the course Complete Freund adjuvant (CFA)-induced persistent pain model. In present study, we found a ligand IL-1R1, termed interleukin-1β (IL-1β), is also significantly at peak sensitivity CFA-evoked Analysis cellular distribution modeling using IMARIS software lumbar dorsal horn, IL-1β...
Slow inward currents (SICs) are known as excitatory events of neurons elicited by astrocytic glutamate via activation extrasynaptic NMDA receptors. By using slice electrophysiology, we tried to provide evidence that SICs can elicit synaptic plasticity. Age dependence and their impact on plasticity was also investigated in both murine human cortical slices. It found induce a moderate plasticity, with features similar spike timing-dependent Overall SIC activity showed clear decline aging...
Epigenetic mechanisms, including histone post-translational modifications (PTMs), play a critical role in regulating pain perception and the pathophysiology of burn injury. However, epigenetic regulation molecular mechanisms underlying injury-induced remain insufficiently explored. Spinal dynorphinergic (Pdyn) neurons contribute to heat hyperalgesia induced by severe scalding-type injury through p-S10H3-dependent signaling. Beyond p-S10H3, may impact various other H3 PTMs. Double...
Epigenetic mechanisms, including histone post-translational modifications (PTMs), play a critical role in regulating pain perception and the pathophysiology of burn injury. However, epigenetic regulation molecular mechanisms underlying injury-induced remain insufficiently explored. Spinal dynorphinergic (Pdyn) neurons contribute to heat hyperalgesia induced by severe scalding-type injury through p-S10H3-dependent signaling. Beyond p-S10H3, may impact various other H3 PTMs. Double...
Although it is known that each spinal cord segment receives thin-fibre inputs from several segmental dorsal roots, remains unclear how these converge at the cellular level. To study whether C- and Adelta-afferents different roots can monosynaptically on to a single substantia gelatinosa (SG) neurone, we performed tight-seal recordings SG neurones in entire lumbar enlargement of rat with all six (L1-L6) attached. The were visualized using our recently developed oblique LED illumination...
Spinal lamina I receives nociceptive primary afferent input to project through diverse ascending pathways, including the anterolateral tract (ALT). Large projection neurons (PNs) form only a few per cent of cell population in this layer, and little is known about their local from other neurons. We combined single-cell imaging isolated spinal cord, paired recordings, 3-D reconstructions biocytin-labelled computer simulations study monosynaptic large ALT-PNs neighbouring (somata separated by...
Abstract Large, mediolaterally oriented neurons in lamina I of the spinal cord, frequently referred to as marginal cells Waldeyer , are known project supraspinal targets via anterolateral tract (ALT). Although dendritic organization has been extensively studied, little is about their local axonal morphology and branching. With help oblique illumination, we visually identified large isolated lumbar enlargement (L1–L6) cord P14–P20 rats. By using intracellular cell‐attached biocytin...
Key points Spinal lamina I is a key element of the pain processing system which relays peripheral inputs to supraspinal areas. In this study, we focused on signal in identified local‐circuit and projection neurones their functionally preserved network an isolated spinal cord preparation. We found that generate spontaneous rhythmic firing, persists presence blockers fast synaptic transmission. describe novel, low‐threshold, primary afferent‐driven inhibitory input neurones, temporally...
Abstract Local‐circuit γ‐aminobutyric acid (GABA)ergic interneurons constitute a diverse population of cells, which remain poorly defined into functionally distinct subclasses. Traditionally, dendritic and axonal arbors have been used to describe cell classes. In the present report, we characterize set hippocampal interneurons, horizontal axo‐axonic located in stratum oriens. They displayed pattern arborization characteristic cells with radially aligned rows boutons making synapses...
Spinal lamina I is a key element of the pain processing system, which integrates primary afferent input and relays it to supraspinal areas. More than 90% neurons in this layer are local circuit neurons, whose role signal poorly understood. We performed whole-cell recordings spinal cord preparation with attached dorsal roots examine morphological features physiological properties small (n = 47) I. Cells successfully filled biocytin 17) had fusiform 10), flattened 4), multipolar 3)...