A5091550849- Pesticide Exposure and Toxicity
- Antimicrobial Peptides and Activities
- Metabolomics and Mass Spectrometry Studies
- Pesticide and Herbicide Environmental Studies
- Analytical chemistry methods development
- Advanced Drug Delivery Systems
- Psychedelics and Drug Studies
- Cholinesterase and Neurodegenerative Diseases
- Neurotransmitter Receptor Influence on Behavior
- Mass Spectrometry Techniques and Applications
- Plant tissue culture and regeneration
- Toxic Organic Pollutants Impact
- Computational Drug Discovery Methods
- Antimicrobial agents and applications
- Natural Products and Biological Research
- Transgenic Plants and Applications
- Cultural Heritage Materials Analysis
- Heavy Metal Exposure and Toxicity
- Venomous Animal Envenomation and Studies
- Invertebrate Immune Response Mechanisms
- Hemoglobin structure and function
- Carcinogens and Genotoxicity Assessment
- Drug Solubulity and Delivery Systems
- Aquaculture disease management and microbiota
- Insect and Pesticide Research
Federal Almazov North-West Medical Research Centre
2020-2024
St Petersburg University
2018-2022
Saint - Petersburg State Chemical Pharmaceutical Academy
2021-2022
Ministry of Health of the Russian Federation
2022
Federal Medical-Biological Agency
2012-2020
Leibniz Institute of Plant Biochemistry
2020
St. Petersburg Research Institute of Radiation Hygiene
2018
Ufa Research Institute of Occupational Health and Human Ecology
2012
The development of intravitreal glucocorticoid delivery systems is a current global challenge for the treatment inflammatory diseases posterior segment eye. main advantages these are that they can overcome anatomical and physiological ophthalmic barriers increase local bioavailability while prolonging controlling drug release over several months to improve safety effectiveness therapy. One approach optimal injections conjugation low-molecular-weight drugs with natural polymers prevent their...
Polymeric drug delivery systems enhance the biopharmaceutical properties of antibiotics by increasing their bioavailability, providing programmable and controlled-release properties, reducing toxicity. In addition, are a promising strategy to improve intestinal permeability various antimicrobial agents, including colistin (CT). This study describes modification conjugates based on CT hyaluronic acid (HA) with cyanocobalamin (vitamin B12). Vitamin B12 was chosen as targeting ligand because it...
Improving the therapeutic characteristics of antibiotics is an effective strategy for controlling growth multidrug-resistant Gram-negative microorganisms. The purpose this study was to develop a colistin (CT) delivery system based on hyaluronic acid (HA) and water-soluble cationic chitosan derivative, diethylaminoethyl (DEAECS). CT polyelectrolyte complex (PEC) obtained by interpolymeric interactions between HA polyanion DEAECS polycation, with simultaneous inclusion positively charged...
Hallucinogenic drugs potently affect brain and behavior have also recently emerged as potentially promising agents in pharmacotherapy. Complementing laboratory rodents, the zebrafish (Danio rerio) is a powerful animal model organism for screening neuroactive drugs, including hallucinogens. Here, we test battery of ten novel N-benzyl-2-phenylethylamine (NBPEA) derivatives with 2,4- 3,4-dimethoxy substitutions phenethylamine moiety −OCH3, −OCF3, −F, −Cl, −Br ortho position phenyl ring N-benzyl...
The growth of microbial multidrug resistance is a problem in modern clinical medicine. Chemical modification active pharmaceutical ingredients an attractive strategy to improve their biopharmaceutical properties by increasing bioavailability and reducing drug toxicity. Conjugation antimicrobial drugs with natural polysaccharides provides high efficiency these systems due targeted delivery, controlled release reduced This paper reports two-step synthesis colistin conjugates (CT) succinyl...
Antimicrobial peptides (AMPs) are not only cytotoxic towards host pathogens or cancer cells but also able to act as immunomodulators. It was shown that some human and non-human AMPs can interact with complement proteins thereby modulate activity. Thus, could be considered the base for complement-targeted therapeutics development. Arenicins from sea polychaete Arenicola marina, classical example of a β-hairpin structure stabilized by disulfide bond, were earlier among most prospective...
Albumin is covalently modified by organophosphorus toxicants (OP) on tyrosine 411, but less than 1% of albumin in humans lethal OP doses that inhibit 95% plasma butyrylcholinesterase. A method enriches OP-modified peptides could aid analysis low dose exposures. Soman or chlorpyrifos oxon treated human was digested with pepsin. were enriched binding to Fe(3+) beads at pH 11 and eluted 2.6 buffer. Similarly, mouse guinea pig pepsin beads. Peptides identified MALDI-TOF/TOF mass spectrometry....
Aims & Objectives: Necrotizing enterocolitis (NEC) primarily affects premature neonates with birth weight less than 1500 g and is characterized by high mortality. This study aimed to identify candidate NEC biomarkers in preterm using serum metabolomics. Methods: A prospective observational of treated 2021-2023 Almazov National Medical Research Centre a retrospective case-control analysis metabolome were performed 31 (cases) without (controls). Patients matched gestational age (cases: 29.0...
The main variants of chronic consciousness disorder (CCD) developing in adverse coma outcome are vegetative state/unresponsive wakefulness syndrome (VS/UWS) and minimal state (MCS). aim the study was to investigate differences metabolomic abnormalities patients with VS / UWS MCS, as well identify changes metabolomics depending on sleep or phase. Materials Methods. Untargeted metabolome analysis blood plasma 10 (group 1) 6 MCS 2) performed using reversed-phase hydrophilic chromatography...
A metabolome is a set of small molecules in the body: peptides, lipids, amino acids, nucleic carbohydrates, biogenic amines, vitamins, minerals, as well any chemical compounds that person comes into contact with, including nutritional supplements, medicines, cosmetics, toxins. Metabolomics study all metabolites present biological system. This science has become reality due to development two modern technological platforms: mass spectrometry, unique mass-charge ratio for each metabolite...