A5078372415- Beetle Biology and Toxicology Studies
- Microbial Natural Products and Biosynthesis
- Natural product bioactivities and synthesis
- Cancer therapeutics and mechanisms
- Genomics, phytochemicals, and oxidative stress
- Metal complexes synthesis and properties
- Synthesis and biological activity
- Fungal Plant Pathogen Control
- Pharmacological Effects of Medicinal Plants
Federal Medical-Biological Agency
2018-2022
Saint-Petersburg State University of Technology and Design
2018
New derivatives of phaeosphaeride A (PPA) were synthesized and characterized. Anti-tumor activity studies carried out on the HCT-116, PC3, MCF-7, A549, К562, NCI-Н929, Jurkat, THP-1, RPMI8228 tumor cell lines, HEF line. All compounds found to have better efficacy than PPA towards lines mentioned. Compound 6 was potent against six cancer PC-3, K562, NCI-H929, RPMI8226, showing a 47, 13.5, 16, 4, 1.5, 7-fold increase in anticancer comparative those etoposide, respectively. 1 possessed...
In the present study, natural phaeosphaeride A (PPA) derivatives are synthesized. Anti-tumor studies carried out on PC3, K562, HCT-116, THP-1, MCF-7, A549, NCI-H929, Jurkat, and RPMI8226 tumor cell lines, human embryonic kidney (HEK293) line. All compounds synthesized turned to have better efficacy than PPA towards lines listed. Among them, three exhibited an ability overcome drug resistance of cells associated with overexpression P-glycoprotein by modulating work this transporter. Luminex...