A5076094215- Crystallography and molecular interactions
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and Characterization of Pyrroles
- Catalytic Cross-Coupling Reactions
- Natural product bioactivities and synthesis
- Chemical Reactions and Isotopes
- Synthesis and biological activity
- Spaceflight effects on biology
- Genomics, phytochemicals, and oxidative stress
- Beetle Biology and Toxicology Studies
- Plant biochemistry and biosynthesis
- Flavonoids in Medical Research
- Pharmacological Effects of Medicinal Plants
- Neurological Disorders and Treatments
- Chemical Synthesis and Analysis
- Sesquiterpenes and Asteraceae Studies
- Catalytic C–H Functionalization Methods
- Click Chemistry and Applications
- Biological Activity of Diterpenoids and Biflavonoids
- Amino Acid Enzymes and Metabolism
- Synthesis and pharmacology of benzodiazepine derivatives
- Metal complexes synthesis and properties
- Crystal structures of chemical compounds
St Petersburg University
2015-2024
State Research Institute of Highly Pure Biopreparations
2022
Federal Medical-Biological Agency
2022
We developed a simple and efficient strategy to access N-vinyl secondary amines of various naturally occurring materials using readily available solid acetylene reagents (calcium carbide, KF, KOH). Pyrrole, pyrazole, indoles, carbazoles, diarylamines were successfully vinylated in good yields. Cross-linked linear polymers synthesized from carbazoles through free radical cationic polymerization. Post-modification olanzapine (an antipsychotic drug substance) was performed.
The asymmetric unit of the title compound, C15H23NO5, contains two independent mol-ecules. Phaeosphaeride A primary sections, an alkyl chain consisting five C atoms and a cyclic system fused five- six-membered rings with attached substituents. In crystal, mol-ecules form layered structures. Nearly planar sheets, parallel to (001) plane, bilayers two-dimensional hydrogen-bonded networks hy-droxy groups located on inter-ior bilayer sheets. network is constructed primarily four O-H⋯O hydrogen...
Introduction. Despite the large-scale use of asymmetric dimethylhydrazine (UDMH) in domestic rocket and space industry, its biomarkers exposure blood plasma urine, as well cardiotoxic effects, have not yet been described. Material methods. The study urine samples rats after a single injection 10 mg/kg UDMH (1/16 LD50) was carried out by HPLC-MS. determination non-metabolized form also using method gas chromatography with mass-selective detection preliminary derivatization...
In the present study, natural phaeosphaeride A (PPA) derivatives are synthesized. Anti-tumor studies carried out on PC3, K562, HCT-116, THP-1, MCF-7, A549, NCI-H929, Jurkat, and RPMI8226 tumor cell lines, human embryonic kidney (HEK293) line. All compounds synthesized turned to have better efficacy than PPA towards lines listed. Among them, three exhibited an ability overcome drug resistance of cells associated with overexpression P-glycoprotein by modulating work this transporter. Luminex...
Abstract The incorporation of a labeled 13 C atom provides plethora opportunities in organic synthesis and catalysis. Structure complicated compounds can be successfully confirmed using the precise location carbon atom; reaction mechanism supported by presence or absence label products; metabolic pathways biological found out depending on concentration analyzed significantly lower for recording successful interpretation NMR spectra, etc . This review aims to provide researcher with common...