A novel synthetic methodology for the preparation of 1,3-disubstituted pyrazoles from in situ generated nitrile imines and acetylene is reported. The reactions are performed a simple two-chamber reactor. One part reactor loaded with hydrazonoyl chloride precursors active imine species base. other used to generate CaC2 water. Partitioning reactants improves yields desired up 99% simplifies their isolation procedure solvent evaporation. approach requires no complex equipment utilizes...

Acetylene is a key building block for organic chemistry and potentially can be involved in diverse range of synthetic transformations. However, critical analysis practical considerations showed that application gaseous acetylene regular labs encounters number difficulties. Safety limitations due to flammable explosive nature requirements specialized high‐pressure equipment impose serious drawbacks. Typical reaction conditions involve excess reactant, which simply released the atmosphere at...

Acetylene was replaced with calcium carbide and utilized for the synthesis of practically useful vinyl thioesters in a simple environmentally benign procedure.

The direct vinylation of an OH group in alcohols and phenols was carried out utilizing easy-to-use CaC₂/KF solid acetylene reagent.

In this work, a novel synthetic methodology for the one-pot preparation of isoxazoles directly from reaction calcium carbide with aldoximes is reported.

A series of biomass-derived alcohols were successfully vinylated with calcium carbide followed by the polymerization. The polymers tested as materials and disassembled back to monomers through pyrolysis.

Industrial activity results in ton-scale production of calcium carbide and generation a significant amount residue (CCR), which is often disposed the environment as waste. CCR an active chemical, rain washes away alkali from sludge, changing pH soils water damaging environment. In this work, we explored new opportunities for utilization view coming industrial uptake digital design additive technologies. Amazingly, can be successfully used filler modification 3D printed materials towards...

Straightforward access to bidentate phosphorus ligands and bis(phosphineoxide)ethanes is described based on atom-economic addition reaction. A practical approach was developed incorporate 2 H 13 C labels using easily available reagents.

The currently known methods for the preparation of vinyl ethers, sulfides and enamines are analyzed described systematically. published data on reactions alcohols, thiols various nitrogen-containing compounds with acetylene, resulting in corresponding derivatives, considered. attention is focused application convenient acetylene sources. Other modern approaches to synthesis derivatives detail, including exchange metathesis reactions, types cross-coupling cleavage organic compounds. Some...

Synthetic methodology enabled by¹³C-elemental carbon is reported. Calcium carbide Ca¹³C₂was applied to introduce a universal¹³C₂unit in the synthesis of labeled alkynes, O,S,N-vinyl derivatives, polymers and¹³C₂-pyridazine drug core.

An electric current promotes copper electrode dissolution in ionic liquids and creates an active catalyst. The catalyst formed was successfully tested synthetic transformations. Reversing the polarity allows regeneration of ILs

Waste after calcium carbide hydrolysis was mixed with and heated to generate H 2 or D up 99% yield, which were used in the hydrogenation. After hydrogen evolution, pure CaO – initial source manufacturing obtained.

We developed a simple and efficient strategy to access N-vinyl secondary amines of various naturally occurring materials using readily available solid acetylene reagents (calcium carbide, KF, KOH). Pyrrole, pyrazole, indoles, carbazoles, diarylamines were successfully vinylated in good yields. Cross-linked linear polymers synthesized from carbazoles through free radical cationic polymerization. Post-modification olanzapine (an antipsychotic drug substance) was performed.

A novel methodology for the preparation of trideuterovinyl derivatives high purity directly from alcohols, thiols, and NH-compounds was developed. Commercially available calcium carbide D2O acted as a D2-acetylene source, DMSO-d 6 used to complete formation D2C=C(D)–X fragment (X = O, S, N). Polymerization selected trideuterovinylated compound showed very promising potential these substances in synthesis labeled polymeric materials. Biological activity synthesized evaluated results indicated...

A method for the protection and deprotection of alcohols <italic>via</italic> vinylation devinylation reactions is proposed. Stability vinyl protecting group under various conditions studied synthetic applicability demonstrated.

A vinylation/devinylation looping system for acetaldehyde manufacturing was evaluated. Vinylation of iso-butanol with calcium carbide under solvent-free conditions combined hydrolysis the resulting iso-butyl vinyl ether slightly acidic conditions. Acetaldehyde produced by collected from reaction mixture simple distillation, and remaining alcohol redirected to vinylation step. All inorganic co-reagents can be looped as well, full sequence is totally sustainable. complete cycle proposed on...

Abstract Acetylene and ethylene are the smallest molecules that contain an unsaturated carbon–carbon bond can be efficiently utilized in a large variety of cycloaddition reactions. In this review, we summarize application these C2 molecular units chemistry highlight their amazing synthetic opportunities. 1 Introduction 2 Fundamental Features Differences Cycloaddition Reactions Involving Ethylene 3 (2+1) 4 [2+2] 5 (3+2) 6 [4+2] 7 (2+2+1) 8 [2+2+2] 9 The Use for Deuterium 13C Labeling 10 Conclusions

Palladium catalysts form a cornerstone of modern chemistry with upmost scientific and industrial impact. Bulk palladium metal itself is chemically inert, sequence chemical transformations has to be utilized convert the into Pd pre-catalyst covered by ligands. However, "cocktail" catalysis concept discovered recently shown that systems can efficiently operate in without necessity complicated expensive pre-installed ligand environment. Here, we point out on green sustainable process for active...

Abstract In recent decades, biodiesel has emerged as a renewable and environmentally benign fuel compared with its fossil counterpart. From an industrial perspective, homogeneously‐catalyzed transesterification been established the principal method for synthesis owing to moderate reaction conditions. However, homogeneous catalysts cannot be reused, large amounts of wastewater accompany their separation from products, making production process detrimental environment contrary sustainable...