A5055434824- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Immune cells in cancer
- Circular RNAs in diseases
- Glycosylation and Glycoproteins Research
- Platelet Disorders and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Alzheimer's disease research and treatments
- Complement system in diseases
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Adipokines, Inflammation, and Metabolic Diseases
- Peripheral Neuropathies and Disorders
- Vagus Nerve Stimulation Research
- Systemic Sclerosis and Related Diseases
- Neurogenesis and neuroplasticity mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Extracellular vesicles in disease
- Immune Cell Function and Interaction
- Lysosomal Storage Disorders Research
- Phagocytosis and Immune Regulation
- Epilepsy research and treatment
- Adenosine and Purinergic Signaling
- Chemokine receptors and signaling
- Cholesterol and Lipid Metabolism
Nazarbayev University
2023-2024
City University of Hong Kong
2023-2024
Chinese University of Hong Kong
2013-2023
Kunming Institute of Zoology
2023
Chinese Academy of Sciences
2023
Brigham and Women's Hospital
2010-2016
Harvard University
2010-2016
Charité - Universitätsmedizin Berlin
2015
Alzheimer's disease (AD) is a multifactorial and fatal neurodegenerative disorder for which the mechanisms leading to profound neuronal loss are incompletely recognized. MicroRNAs (miRNAs) recently discovered small regulatory RNA molecules that repress gene expression increasingly acknowledged as prime regulators involved in human brain pathologies. Here we identified two homologous miRNAs, miR-132 miR-212, downregulated temporal cortical areas CA1 hippocampal neurons of AD brains....
Monocytic cells exhibit a high level of heterogeneity and have two distinct modes their activation: 1) classical M1 path associated with inflammation tissue damage, 2) alternative M2 path. Although it has been demonstrated that macrophages play an important role in the regulation allergic immune responses, maintenance repair, little is known about mechanisms determine phenotype. We previously shown miR-124 expressed microglia phenotype overexpression resulted downregulation number markers...
The process of macrophage polarisation is involved in many pathologies such as anti-cancer immunity and autoimmune diseases. Polarized macrophages exhibit various levels plasticity when M2/M(IL-4) are reprogrammed into an M1-like phenotype following treatment with IFNγ and/or LPS. At the same time, M1 resistant to reprogramming presence M2-like stimuli. molecular mechanisms responsible for polarization, M2 macrophages, lack remain unknown. Here, we explored role Egr2 induction maintenance...
Rationale : Platelets are known to participate in vascular pathologies; however, their role neuroinflammatory diseases, such as multiple sclerosis (MS), is unknown. Autoimmune CD4 T cells have been the main focus of studies MS, although factors that regulate T-cell differentiation toward pathogenic helper-1/T helper-17 phenotypes not completely understood. Objective We investigated platelets modulation functions patients with MS and mice experimental autoimmune encephalitis, an animal model...
Although it has been demonstrated that cAMP pathway affect both adaptive and innate cell functions, the role of this in regulation T-cell mediated central nervous system (CNS) autoimmune inflammation, such as experimental encephalomyelitis (EAE), remains unclear. It is also unclear how function CD4 T cells vivo at site inflammation. We found adenylyl-cyclase activator Forskolin besides inhibition functions upregulated miR-124 CNS during EAE, which associated with M2 phenotype...
Platelets respond to vascular damage and contribute inflammation, but their role in the neurodegenerative diseases is unknown. We found that systemic administration of brain lipid rafts induced a massive platelet activation degranulation resulting life-threatening anaphylactic-like response mice. were engaged by sialated glycosphingolipids (gangliosides) integrated rigid structures astroglial neuronal rafts. The brain-abundant gangliosides GT1b GQ1b specifically recognized platelets this...
Abstract In contrast to peripheral macrophages, microglia in the central nervous system (CNS) exhibit a specific deactivated phenotype; however, it is not clear how this phenotype maintained. Two alternative hypotheses were postulated recently: (a) differ from macrophages being derived yolk sac (YS), whereas originate bone marrow (BM); (b) acquire under influence of CNS microenvironment. We have previously shown that express miR‐124, which was also induced BM‐derived co‐cultured with...
Microglia are cells of the myeloid lineage that reside in central nervous system (CNS)1. These play an important role pathologies many diseases associated with neuroinflammation such as multiple sclerosis (MS)2. a normal CNS express macrophage marker CD11b and exhibit resting phenotype by expressing low levels activation markers CD45. During pathological events CNS, microglia become activated determined upregulation CD45 other markers3. The factors affect functions not well studied....
MicroRNAs (miRNAs) are regulatory molecules that play an important role in many physiological processes, including cell growth, differentiation, and apoptosis. In addition to modulating normal cellular functions, it has also been reported miRNAs involved the development of pathologies, cardiovascular diseases, cancer, inflammation, neurodegeneration. Methods for sensitive detection measurement specific their targets essential both basic research endeavours, as well diagnostic efforts aimed...
Background Glatiramer acetate (GA, Copaxone, Copolymer-1) is an FDA approved drug for the treatment of MS and it very effective in suppressing neuroinflammation experimental autoimmune encephalitis (EAE), animal model MS. Although this was designed to inhibit pathogenic T cells, exact mechanism EAE/MS suppression by GA still not well understood. Previously we presented evidence that platelets become activated promote EAE, suggesting a possible role EAE. We hypothesized could affecting only...
Gangliosides are glycosphingolipids, which abundant in brain, known to modulate ion channels and cell-to-cell communication. Deficiencies can result aberrant myelination altered immune responses, give rise neurodevelopmental psychiatric disorders. However, date, little mechanistic data is available on how ganglioside deficiencies contribute the behavioural In humans, loss of lactosylceramide-alpha-2,3-sialyltransferase (ST3Gal5) leads a severe neuropathology, but ST3Gal5 knock-out...
Complement system plays an important role in the immune defense against pathogens; however, recent studies demonstrated of complement subunits C1q, C4, and C3 normal functions central nervous (CNS) such as non-functional synapse elimination (synapse pruning), during various neurologic pathologies. Humans have two forms C4 protein encoded by C4A C4B genes that share 99.5% homology, while mice only one gene is functionally active cascade. Overexpression human was shown to contribute...
Neurologic disorders such as traumatic brain injury, multiple sclerosis, Alzheimer’s disease, and drug-resistant epilepsy have a high socioeconomic impact around the world. Current therapies for these are often not effective. This creates demand development of new therapeutic approaches to treat disorders. Recent data suggest that autoreactive naturally occurring immunoglobulins produced by subsets B cells called B1 combined with complement actively involved in processes restoration neuronal...
Microglia are cells of the myeloid lineage that reside in central nervous system (CNS)1. These play an important role pathologies many diseases associated with neuroinflammation such as multiple sclerosis (MS)2. a normal CNS express macrophage marker CD11b and exhibit resting phenotype by expressing low levels activation markers CD45. During pathological events CNS, microglia become activated determined upregulation CD45 other markers3. The factors affect functions not well studied....
A deficiency in GM3-derived gangliosides, resulting from a lack of lactosylceramide-alpha-2,3-sialyltransferase (ST3GAL5), leads to severe neuropathology, including epilepsy and metabolic abnormalities. Disruption ganglioside production by this enzyme may also have role the development neuropsychiatric disorders. ST3Gal5 knock-out (St3gal5−/−) mice a-, b-, c-series but exhibit no overt possibly owing compensatory 0-series glycosphingolipids. Here, we sought investigate possibility that...
Abstract Lipid metabolism is important for alternative (M2) macrophage activation, but it remains unclear whether essential this process, and the underlying mechanisms have yet to be determined. It also how M2 phenotype induced during resolution of inflammation tissue repair. We used large-scale RNA-sequencing high-throughput lipidomics approaches identify that blood coagulation, granulocytes release certain lipids are loaded onto high-density lipoproteins (HDLs), which then act via...