A5071745506- Protein Degradation and Inhibitors
- Chemical Synthesis and Reactions
- Asymmetric Hydrogenation and Catalysis
- Sulfur-Based Synthesis Techniques
- Catalytic C–H Functionalization Methods
- Additive Manufacturing and 3D Printing Technologies
- Chemical Synthesis and Analysis
- Photopolymerization techniques and applications
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- Bone Tissue Engineering Materials
- Antimicrobial agents and applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Catalytic Cross-Coupling Reactions
- Silicone and Siloxane Chemistry
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Cyclopropane Reaction Mechanisms
- Multiple Myeloma Research and Treatments
- CAR-T cell therapy research
- Parasites and Host Interactions
- Drilling and Well Engineering
- Astronomical Observations and Instrumentation
- Occupational exposure and asthma
- Microwave-Assisted Synthesis and Applications
Nankai University
2020-2025
Zaozhuang University
2024-2025
State Key Laboratory of Medicinal Chemical Biology
2021-2025
State Key Laboratory of Chemical Engineering
2025
Zhejiang University of Science and Technology
2024
Jiangxi Agricultural University
2019
Northwestern Polytechnical University
2012-2015
Great Wall Motors (China)
2008
Acute myeloid leukemia (AML) refers to one of the most lethal blood malignancies worldwide. FLT3-ITD mutation is recognized as common that predicted a poorer prognosis. There have been many prominent inhibitors approved by FDA for clinical therapies. However, impacted undesirable off-target effects, differentiated metabolic issues, and drug resistance problems, it remains challenging discover alternative promising solutions treating FLT3-ITD+ AML. In this study, dovitinib was chemically...
High strength and low dielectric constant materials are highly desirable in the areas of electronics communication. In this work, two kinds multifunctional branched silicone acrylates (DQEA QSIEA) were designed synthesized from 2,4,6,8-tetramethylcyclotetrasiloxane tetrakis (dimethylsiloxy)silane a concise synthetic route. Owing to enhanced flexibility cross-linking networks provided by organosilicone, elongation at break impact modified epoxy resins significantly increased more than 20%...
A novel and efficient method for synthesizing carboxamides has been developed, utilizing a base-promoted Lossen rearrangement of hydroxylamine derivatives. In this reaction, the derivatives are bench-top stable easy...
A silver-catalyzed cross coupling of cyclic aldimines and α-imino-oxy acids has been developed. The solvent-dependent reaction could selectively deliver either imine moiety retained nitriles or ring-opened oxonitriles in moderate yields.
Small-cell lung cancer (SCLC) represents a significant public health challenge due to its increasing incidence and high mortality. Most SCLC patients are diagnosed at advanced stages, there limited effective targeted therapies available. In this study, potent selective CDK9 degrader, C3, was developed through PROTAC modification of the inhibitor, AT-7519. C3 effectively induced apoptosis in various cell lines low nanomolar concentrations demonstrated favorable vivo tolerance adequate oral...
In the degradation of poly(ethylene terephthalate) (PET), mono(2-hydroxyethyl) terephthalate (MHET) hydrolase (IsMHETase) plays a crucial role in complete PET. Although IsMHETase was discovered concurrently with IsPETase, its structural and functional properties are not well understood. To enhance thermal stability IsMHETase, we selected six homologous proteins that share closest evolutionary relationship for structure-based protein rational design, all exhibiting over 60% amino acid...
In this study, a robust and facile method for desulfonation to achieve secondary amines is demonstrated.
Triple-negative breast cancer (TNBC) has been considered the most aggressive and mortal cancer. Thus far, it remains an important challenge to develop TNBC targeted therapy. As revealed from numerous recent studies, ANXA2 may be a potential target treat TNBC. In present study, natural product 5α-epoxyalantolactone (5α-EAL) was discovered as anti-breast stem cells (BCSCs) lead compound. Furthermore, 5α-EAL found able notably suppress function of by covalently targeting cysteine 9 (Cys9)...
In order to improve the cell compatibility of biomedical carbon/carbon composites, Ti6Al4V coatings were applied on composites by magnetron sputtering technique. The microstructure and responses evaluated, bonding strength between was analyzed. modulated surface morphology, decreased roughness, improved wettability achieved a strong composites. cells showed larger extension higher proliferation for than Copyright © 2012 John Wiley & Sons, Ltd.
Abstract ATR has emerged as a promising target for anti‐cancer drug development. Several potent inhibitors are currently undergoing various stages of clinical trials, but none have yet received FDA approval due to unclear regulatory mechanisms. In this study, we discovered and selective degrader. Its kinase‐independent functions in acute myeloid leukemia (AML) cells were elucidated using proteolysis‐targeting chimera (PROTAC) molecule probe. The degrader, 8 i , exhibited significantly...
Additive manufacturing (AM) elastomers are highly desirable due to their huge potential applications ranging from car industry and wearable electronics tissue engineering. However, photocurable AM elastomers, which could well meet the requirements for vat photopolymerization (VPP) 3D printing in low-cost high resolution as high-performance, remain rare. Herein, a glycerol polyether (GP)-based elastomer was constructed commercially friendly industrially feasible solution. The GP acrylate...
Abstract A robust Pd(0)-catalyzed decarboxylation alkylation has been developed to construct quaternary stereocenters through the use of chiral tert-butanesulfinamide as directing group. This strategy provides a simple and efficient route construction centers at α-position sulfinamides, with high diastereoselectivities yields.