A5100453917- Circular RNAs in diseases
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- Cardiac Fibrosis and Remodeling
- Cancer Mechanisms and Therapy
- Congenital heart defects research
- Retinoids in leukemia and cellular processes
- Aortic aneurysm repair treatments
- Ferroptosis and cancer prognosis
- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Viral-associated cancers and disorders
- Catalytic C–H Functionalization Methods
- Neonatal Respiratory Health Research
- Coenzyme Q10 studies and effects
- Antioxidant Activity and Oxidative Stress
- Enzyme Catalysis and Immobilization
- Natural product bioactivities and synthesis
- Quinazolinone synthesis and applications
- Microbial metabolism and enzyme function
- Animal Genetics and Reproduction
Zaozhuang University
2025
Xuzhou Medical College
2024
Sun Yat-sen University Cancer Center
2023
Sun Yat-sen University
2023
Harbin Medical University
2009-2023
Fourth Affiliated Hospital of Harbin Medical University
2009-2023
Guangzhou Medical University
2022-2023
Peking University
2019-2021
State Key Laboratory of Natural and Biomimetic Drugs
2019-2021
Zhejiang University
2015
Abstract Changes in gene expression lung epithelial cells are detected cancer tissues during exposure to pollutants, highlighting the importance of gene‐environmental interactions disease. Here, a Cd‐induced malignant transformation model mouse lungs and bronchial cell lines is constructed, differences non‐coding circRNAs analyzed. The migratory invasive abilities Cd‐transformed suppressed by circCIMT. A significant DNA damage response observed after Cd, which increased further following...
Pathological cardiac hypertrophy induced by adrenergic overactivation can subsequently develop to heart failure which remains as a leading cause of mortality worldwide.Tanshinone IIA is lipid-soluble pharmacologically active compound extracted from the rhizome Chinese herb Salvia miltiorrhiza, well-known traditional medicine used for treatment cardiovascular disorders.However, little know about effect Tanshinone on hypertrophy.The present study was aimed investigate whether prevents...
Deregulated migration and proliferation of vascular smooth muscle cells (VSMCs) acts a crucial role in the pathogenesis many cardiovascular diseases such as atherosclerosis, coronary heart disease hypertension. Long noncoding RNAs (lncRNAs) play functional roles lot biological processes cell development, proliferation, differentiation invasion. In our study, we demonstrated that BANCR expression level was upregulated atherosclerotic plaques tissues compared to normal vessels tissues. TNF-α...
Background: Neo-adjuvant chemotherapy is an effective strategy for improving treatment of breast cancers. However, the efficacy this limited triple negative cancer (TNBC). Gene therapy may be a more prognosis TNBC. Methods: A novel 25 nucleotide sense strand miRNA was designed to treat TNBC by silencing Slug gene, and encapsulated into DSPE-PEG2000-tLyp-1 peptide-modified functional liposomes. The liposomes evaluated on invasive cells cancer-bearing nude mice. Furthermore, vinorelbine were...
A silver-catalyzed cross coupling of cyclic aldimines and α-imino-oxy acids has been developed. The solvent-dependent reaction could selectively deliver either imine moiety retained nitriles or ring-opened oxonitriles in moderate yields.
Defects in the DNA damage response (DDR) are associated with tumorigenesis, and circular RNAs (circRNAs) can also affect occurrence progression of cancer by regulating gene expression. However, relationship between lung circRNAs remains unexplored. In this study, circ_0004470 was significantly upregulated various cells (H446, A549, H1299) as well carcinogenic animal models clinical samples. Circ_0004470 promoted cell cycle S phase arrest human pulmonary bronchial epithelial cells, inhibited...
Myocardial infarction (MI) is a severe coronary artery disease and leading cause of mortality morbidity worldwide. However, the molecular mechanisms MI have yet to be fully elucidated. In this study, we compiled MI-related genes, microRNAs (miRNAs) known human transcription factors (TFs), then identified 1,232 feed-forward loops (FFLs) among these miRNAs, TFs their co-regulated target genes through integrating prediction. By merging FFLs, first miRNA TF mediated regulatory network for was...
Abdominal aortic aneurysm (AAA) is a common disease that associated with the proliferation and apoptosis of vascular smooth muscle cells (VSMCs). VSMCs are regulated by microRNAs (miRNA). The aim present study was to identify miRNA sequences regulate SMCs during AAA. miRNA‑504 identified using PCR array reverse transcription‑quantitative polymerase chain reaction analysis, its expression levels were observed be downregulated in derived from patients AAA when compared controls. Transfection...
Circular RNAs (circRNAs) are widely expressed in mammals and act as regulatory targets the atherogenesis. The objective of this study was to research biological role molecular mechanism circ_0093887 oxidized low-density lipoprotein (ox-LDL)-induced atherosclerosis (AS) human aortic endothelial cells (HAECs). Cell viability detection performed by CCK-8 assay. Inflammatory molecules were examined using ELISA. Flow cytometry used measure cell-cycle progression cell apoptotic rate. Caspase 3...
Atherosclerosis and coronary heart disease are characterized by a hyperplastic neointima inflammation involving cytokines, such as tumor necrosis factor‑α (TNF‑α). TNF‑α is pleiotropic mediates proliferation in various cell types, vascular smooth muscle cells (VSMCs). The molecular mechanism for the effects of has not previously been fully elucidated. current study identified that expression microRNA‑25 (miR‑25), small noncoding RNA, was reduced response to signaling VSMCs. Restored miR‑25...
Abstract The differentiation therapy of breast cancer stem cells (CSCs) represents a significant strategy to treat cancer, but inefficient delivery CSCs hinders the efficacy agents. In this work, we report type functional dendrisomes constructed by synthesized amphiphilic dendrimers, which enhance cellular uptake CSCs, differentiate carrying all-trans retinoic acid (ATRA), and increase anticancer ATRA docetaxel (DTX) in vitro cancer-bearing mice. study further reveals mechanism uncovers...
The epithelial sodium channel (ENaC) in cortical collecting duct (CCD) principal cells plays a critical role regulating systemic blood pressure. We have previously shown that cholesterol (Cho) the apical cell membrane regulates ENaC; however, underlying mechanism remains unclear.Patch-clamp technique and confocal microscopy were used to evaluate ENaC activity density.Here we show extraction of Cho with methyl-β-cyclodextrin (MβCD) significantly reduced amiloride-sensitive current...
Abstract Cigarette smoking-induced chronic inflammation has been considered a vital driver of lung tumorigenesis. The compounds 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), tobacco-specific carcinogen, and lipopolysaccharide (LPS), an inflammatory inducer, are important components tobacco smoke which have implicated in inflammation-driven carcinogenesis. However, the biological effects underlying mechanisms LPS-mediated on NNK-induced tumorigenesis still unclear. In this study,...
Epstein-Barr virus (EBV) C promoter (Cp) hypermethylation, a crucial factor for EBV latent infection of nasopharyngeal epithelial cells, has been recognized as promising biomarker carcinoma (NPC) detection. In this study, we develop novel Cp methylation quantification (E-CpMQ) assay and evaluate its diagnostic performance NPC
Alpha-lipoic acid (α-LA) is a potent antioxidant that acts as an essential cofactor in mitochondrial dehydrogenase reactions. α-LA has been shown to possess anti-inflammatory and cytoprotective properties, used improve symptoms of diabetic neuropathy. However, the role stem cell differentiation underlying molecular mechanisms remain unknown. In present study, we showed significantly promoted dimethyl sulfoxide (DMSO)-induced cardiomyogenic mouse embryonic carcinoma P19 cells. dose...
Airway remodeling is a major pathological characteristic of chronic obstructive pulmonary disease (COPD). This study aimed to investigate the effect Abhd2 deficiency on ovalbumin (OVA)-induced airway and inflammation in vivo. Abhd2-deficient mice were used establish an OVA-induced asthma model. Lung tissues analyzed using hematoxylin eosin (HE) staining, Masson immunohistochemistry, quantitative reverse transcription- polymerase chain reaction (qRT-PCR), western blotting determine role...
The MADS box-containing transcription factors MEF2A-D regulate the expression of most skeletal and cardiac muscle structural genes. Recently, a zinc finger protein called HZF1 was identified as factor, found to be highly expressed in muscle. By screening regulatory region HZF1, we that myocyte enhancer factor 2 (MEF2) potentially recognizes binds gene. We also knockdown MEF2A endogenous human aortic smooth cells decreases while enforced turn promotes HZF1. Furthermore, employed luciferase...
Congenital heart diseases (CHD) are a large group of prevalent and complex anatomic malformations the heart, with genetic basis remaining largely unknown. Since genes or factors associated differentiation human embryonic stem (HES) cells would affect development all tissues, including cardiac progenitor cells, we postulated their potential roles in CHD. In this study, focused on ZW10, kinetochore protein involved process proper chromosome segregation, conducted comparative studies between...