A5101607187- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Sphingolipid Metabolism and Signaling
- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
- RNA regulation and disease
- Asthma and respiratory diseases
- S100 Proteins and Annexins
- Biochemical effects in animals
- Neonatal Respiratory Health Research
- Immune cells in cancer
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- RNA Interference and Gene Delivery
- Lipid metabolism and disorders
- MicroRNA in disease regulation
- Nitric Oxide and Endothelin Effects
- Cancer-related gene regulation
- Gut microbiota and health
- Psoriasis: Treatment and Pathogenesis
- Natural product bioactivities and synthesis
- Endoplasmic Reticulum Stress and Disease
- Neurological Disorders and Treatments
- Mycobacterium research and diagnosis
Harbin Medical University
2010-2023
First Affiliated Hospital of Harbin Medical University
2010-2023
Fourth Affiliated Hospital of Harbin Medical University
2010-2023
Sichuan Agricultural University
2011
During many pathological conditions, the tryptophan concentration in blood may be reduced. However, effects of oxidative stress on metabolism remain unknown. In this study, we investigated growth performance and weaned pigs. A total 24 pigs were assigned to one three treatments that included fed ad libitum (control), challenged with diquat at a dose 10 mg/kg BW (oxidative stress) or pair-fed receive same amount feed as diquat-challenged The trial lasted for 7 days. activities antioxidant...
Microglial hyperactivation mediated by sphingosine kinase 1/sphingosine-1-phosphate (SphK1/S1P) signalling and the consequent inflammatory mediator production serve as key drivers of cerebral ischaemia-reperfusion injury (CIRI). Although SphK1 reportedly controls autophagy microglial activation, it remains uncertain to whether is similarly capable regulating damage CIRI-activated microglia. In current study, we adopted both in vitro oxygen-glucose deprivation reperfusion (OGDR) models vivo...
Sphingosine kinase 1 (Sphk1) and the signaling molecule sphingosine-1-phosphate (S1P) are known to be key regulators of a variety important biological processes, such as neovascularization. Nitric oxide (NO) is also play role in vasoactive properties, whether Sphk1/S1P able alter angiogenesis context cerebral ischemia-reperfusion injury (IRI), activity linked with NO production, however, remains uncertain.We used immunofluorescence detect expression Sphk1 NOS epithelial cells (EC) after IR...
Airway remodeling is a major pathological characteristic of chronic obstructive pulmonary disease (COPD). This study aimed to investigate the effect Abhd2 deficiency on ovalbumin (OVA)-induced airway and inflammation in vivo. Abhd2-deficient mice were used establish an OVA-induced asthma model. Lung tissues analyzed using hematoxylin eosin (HE) staining, Masson immunohistochemistry, quantitative reverse transcription- polymerase chain reaction (qRT-PCR), western blotting determine role...
Ischemic stroke comprises 75% of all strokes and it is associated with a great frailty casualty rate. Certain data suggest multiple long non-coding Ribonucleic Acids (lncRNAs) assist the transcriptional, post-transcriptional, epigenetic regulation genes expressed in CNS (Central Nervous System). However, these studies generally focus on differences expression patterns lncRNAs Messenger (mRNAs) tissue samples before after cerebral ischemic injury, ignoring effects age.
Abstract Background : Microglial hyperactivation driven by SphK1/S1P signaling and consequent inflammatory mediator production is a key driver of cerebral ischemia-reperfusion injury (CIRI). While SphK1 reportedly controls autophagy microglial activation, it remains uncertain as to whether similarly able regulate damage mediated CIRI-activated microglia. Methods: In the present study, we utilized both an in vitro oxygen-glucose deprivation reperfusion (OGDR) model vivo rat focal CIRI test...