A5010119797- Advanced MRI Techniques and Applications
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Computational Drug Discovery Methods
- Machine Learning in Materials Science
- Vestibular and auditory disorders
- Genetics, Bioinformatics, and Biomedical Research
- Aquaculture disease management and microbiota
- Protein Structure and Dynamics
- Coral and Marine Ecosystems Studies
- Radiomics and Machine Learning in Medical Imaging
- Advanced Malware Detection Techniques
- Hearing, Cochlea, Tinnitus, Genetics
- Chemical Synthesis and Analysis
- Medical Imaging Techniques and Applications
- Hearing Loss and Rehabilitation
- RNA Interference and Gene Delivery
- Mycobacterium research and diagnosis
- Marine Sponges and Natural Products
- Intracranial Aneurysms: Treatment and Complications
- Flavonoids in Medical Research
- Adenosine and Purinergic Signaling
- Silkworms and Sericulture Research
- Cerebrovascular and Carotid Artery Diseases
- Antimicrobial agents and applications
Chinese PLA General Hospital
2018-2025
South China Sea Institute Of Oceanology
2010-2024
Institute of Oceanology
2010-2024
Chinese Academy of Sciences
2022-2024
Chinese People's Liberation Army
2023
State Council of the People's Republic of China
2023
Peking University
2017-2021
State Key Laboratory of Natural and Biomimetic Drugs
2019
Institute of Information Engineering
2019
State Key Laboratory of Information Security
2018
The ultimate goal of drug design is to find novel compounds with desirable pharmacological properties. Designing molecules retaining particular scaffolds as their core structures an efficient way obtain potential candidates. We propose a scaffold-based molecular generative model for discovery, which performs molecule generation based on wide spectrum scaffold definitions, including Bemis–Murcko scaffolds, cyclic skeletons, and specifications side-chain can generalize the learned chemical...
Antibiotic resistance is one of the biggest threats to public health, and new antibacterial agents hence are in an urgent need combat infectious diseases caused by multidrug-resistant (MDR) pathogens. Utilizing dimerization strategy, we rationally designed efficiently synthesized a series small molecule dimeric lysine alkylamides as mimics AMPs. Evaluation these against panel Gram-positive Gram-negative bacteria including MDR strains was performed, broad-spectrum potent compound 3d...
A large training dataset with high-quality annotations is necessary for building an accurate and generalisable deep learning system, which can be difficult expensive to prepare in medical applications. We present a novel deep-learning-based requiring no annotator but weak annotation from diagnosis report, performance detecting multiple head disorders CT scans, including ischaemia, haemorrhage, tumours, skull fractures.Our system was developed on 104 597 scans the Chinese PLA General...
Target fishing often relies on the use of reverse docking to identify potential target proteins ligands from protein database. The limitation is accuracy current scoring funtions used distinguish true non-target proteins. Many contemporary functions are designed for virtual screening small molecules without special optimization docking, which would be easily influenced by properties pockets, resulting in bias with certain properties. This cause lots false positives interferring...
Background Precise diagnosis and early appropriate treatment are of importance to reduce neuromyelitis optica spectrum disorder (NMOSD) multiple sclerosis (MS) morbidity. Distinguishing NMOSD from MS based on clinical manifestations neuroimaging remains challenging. Purpose To investigate radiomic signatures as potential imaging biomarkers for distinguishing MS, develop validate a diagnostic radiomic‐signature‐based nomogram individualized disease discrimination. Study Type Retrospective,...
Identifying brain abnormalities in autism spectrum disorder (ASD) is critical for early diagnosis and intervention. To explore differences ASD typical development (TD) individuals by detecting structural features using T1-weighted magnetic resonance imaging (MRI), we developed a deep learning-based approach, three-dimensional (3D)-ResNet with inception (I-ResNet), to identify participants TD propose gradient-based backtracking method pinpoint image areas that I-ResNet uses more heavily...
This study aimed to evaluate the diagnostic value of ultrahigh-field magnetic resonance imaging (MRI) for brain tumors in clinical practice.Thirty patients with underwent 7- and 3-T MRI. The performance confidence MRI visualization tumor details such as internal structure feeding artery were evaluated by radiologists. Contrast-enhanced region detail score (DCS) calculated compared between 7 3T using Wilcoxon rank sum test.In 19 obvious enhancement 11 cases without enhancement, showed similar...
Abstract The differentiation therapy of breast cancer stem cells (CSCs) represents a significant strategy to treat cancer, but inefficient delivery CSCs hinders the efficacy agents. In this work, we report type functional dendrisomes constructed by synthesized amphiphilic dendrimers, which enhance cellular uptake CSCs, differentiate carrying all-trans retinoic acid (ATRA), and increase anticancer ATRA docetaxel (DTX) in vitro cancer-bearing mice. study further reveals mechanism uncovers...
Natural products play a vital role in the drug discovery and development process as an important source of reliable novel lead structures. But existing criteria for leads were usually developed synthetic compounds cannot be directly applied to identify scaffolds from natural products. To solve this problem, we propose method predict indications privileged design. A deep learning model was built Entropy-based information metrics used each indication Privileged Scaffold Dataset (PSD)...
Background and purpose Individuals with intracranial artery occlusion have high rates of ischaemic events recurrence. It has been challenging to identify patients who had high-risk stroke using a simple, valid non-invasive screening approach. This study aimed investigate whether fluid-attenuated inversion recovery (FLAIR) vascular hyperintensity (FVH), specific imaging sign on the FLAIR sequence, could be predictor in population internal carotid (ICA) or middle cerebral (MCA) occlusion....
Background Ultra‐high field 7T MRI can provide excellent tissue contrast and anatomical details, but is often cost prohibitive, not widely accessible in clinical practice. Purpose To generate synthetic images from acquired 3T with deep learning to evaluate the feasibility of this approach for brain imaging. Study Type Prospective. Population 33 healthy volunteers 89 patients diseases, divided into training, evaluation datasets ratio 4:1. Sequence Field Strength T1‐weighted nonenhanced or...
Molecular fingerprints are the workhorse in ligand-based drug discovery. In recent years, an increasing number of research papers reported fascinating results on using deep neural networks to learn 2D molecular representations as fingerprints. It is anticipated that integration learning would also contribute prosperity 3D Here, we unprecedentedly introduce into small molecule fingerprints, presenting a new one termed three-dimensional force fields fingerprint (TF3P). TF3P learned by capsular...
The outbreak of coral-eating Acanthaster spp., commonly known as the Crown-of-Thorn Starfish (CoTS), contributes to a significant proportion coral loss in tropical Indo-Pacific region. After dramatic due their predation, CoTS is expected face food shortages before recovers, which usually accompanied by sudden disappearance its population. To reveal response starvation stress, we conducted four-month experiment investigate physiological and molecular changes stomach tissue combining...
Tinnitus is frequently found in patients with vestibular schwannoma (VS), but its underlying mechanisms are currently unclear.Both preoperative (VS pre ) and postoperative post functional MR images were collected from 32 unilateral VS matched healthy controls (HCs). Connectome gradients generated for the identification of altered regions perturbed gradient distances. measurements conducted predictive analysis neuroimaging-genetic integration analysis.There 56.25% 65.63% suffering ipsilateral...
Combined use of drugs is a hot spot in the research new nowadays, and traditional Chinese medicine (TCM) classic practice combined drugs. In this paper, compatibility TCM prescriptions related properties composed herbs were calculated studied to verify discuss feasibility results guiding compatibility. Research Group on New Drug Design, Institute Materia Medica, China Academy Medical Sciences had established structured database by using inheritance support system (TCMISS V2.0), including 4...
Control-flow attacks cause powerful threats to the software integrity. Remote attestation for control flow is a crucial security service ensuring integrity on embedded platforms. The fine-grained remote control-flow with execution-profiling Control-Flow Graph (CFG) applied defend against attacks. It safe scheme but it may influence runtime efficiency. In fact, we find out only vulnerable parts of program need being attested at costly level ensure security, and remaining normal just...
Abstract As an efficient way of computational target prediction, reverse docking can find not only potential targets but also binding modes for a query ligand. Though the number available tools keeps expanding, there is still comprehensive evaluation study which uncover advantages and limitations these strategies in research field target‐fishing. In this study, we propose brand‐new dataset tailor‐made docking, composed true positive set (the core set) two negative sets similar decoy...
Genetic linkage maps were constructed for the noble scallop Chlamys nobilis Reeve on basis of 373 amplified fragment length polymorphisms (AFLPs) and 9 microsatellite markers. The pseudo test-cross mapping strategy was used to construct maps. female map contained 117 (115 AFLPs 2 microsatellites) markers spanning 1,698.6 cM, with an average interval 16.8 cM. male had 108 (106 covering 1,519.0 at 16.5 cM per marker. Sixteen groups identified in both maps, which consistent 16 chromosomes seen...
<title>Abstract</title> The crown-of-thorns starfish (CoTS), also known as <italic>Acanthaster</italic> spp., is responsible for a considerable amount of coral loss in the tropical Indo-Pacific region. After decimating populations through predation, it anticipated that CoTS will face food scarcity before recovery. It unclear how respond to starvation stress. Therefore, we conducted four-month stress experiment on CoTS, and analyzed response characteristics its stomach bacterial communities...
Background: The mechanism of tinnitus is unclear and when accompanying vestibular schwannoma (VS), can seriously reduce patients’ quality life. This study aimed to determine the correlation between preoperative clinical characteristics VS, postoperative changes in brain function, patients with VS through a cohort study. Methods: We collected data from 80 preoperatively 28 postoperatively, recruited healthy controls. used Chi-squared tests unpaired t-tests identify significant effect. paired...
Abstract Objective Magnetic resonance guided focused ultrasound (MRgFUS) thalamotomy has been shown to be safe and effective treat various types of tremor diseases, but whether the clinical status these patients was involved still unknown. Methods We retrospectively studied symptoms variables (at hospitalization) 59 essential (ET) subjected with MRgFUS thalamotomy. Patients were categorized by short-term relieve recurrence within 12 months. Multivariate logistic regression used screen...