A5054561588- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Advanced MRI Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Advanced Neuroimaging Techniques and Applications
- Neurological disorders and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Atomic and Subatomic Physics Research
- Parkinson's Disease Mechanisms and Treatments
- MRI in cancer diagnosis
- Genetic Neurodegenerative Diseases
- Moyamoya disease diagnosis and treatment
- Quantum, superfluid, helium dynamics
- Functional Brain Connectivity Studies
- Neurological Disease Mechanisms and Treatments
- Glioma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- DNA Repair Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Neurological Complications and Syndromes
- Advanced biosensing and bioanalysis techniques
- Telomeres, Telomerase, and Senescence
- Cancer Mechanisms and Therapy
- Advanced NMR Techniques and Applications
- Cardiovascular Health and Disease Prevention
Chinese PLA General Hospital
2019-2024
Sun Yat-sen University
2023
Chinese People's Liberation Army
2023
The First Affiliated Hospital, Sun Yat-sen University
2023
Abstract Aims Our purpose is to assess the role of cerebral small vessel disease (SVD) in prediction models patients with different subtypes acute ischemic stroke (AIS). Methods We enrolled 398 small‐vessel occlusion (SVO) and 175 large artery atherosclerosis (LAA) AIS patients. Functional outcomes were assessed using modified Rankin Scale (mRS) at 90 days. MRI was performed white matter hyperintensity (WMH), perivascular space (PVS), lacune, microbleed (CMB). Logistic regression (LR)...
CST (CTC1-STN1-TEN1) is a telomere associated complex that binds ssDNA and required for multiple steps in replication, including termination of G-strand extension by telomerase synthesis the complementary C-strand. contains seven OB-folds which appear to mediate function modulating binding ability recruit or engage partner proteins. However, mechanism whereby achieves its various functions remains unclear. To address mechanism, we generated series CTC1 mutants studied their effect on rescue...
Although the lungs are primary organ involved, increasing evidence supports neuroinvasive potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study investigates relationship between disease (COVID-19)-related deterioration brain structure and degree damage to lung function. Nine COVID-19 patients were recruited in critical condition from Jin Yin-tan Hospital (Wuhan, China) who had been discharged 4 February 27 2020. The demographic, clinical, treatment, laboratory...
Glioma genotypes are of importance for clinical decision-making. This data can only be acquired through histopathological analysis based on resection or biopsy. Consequently, there is a need alternative biomarkers that noninvasively provide reliable information preoperatively identifying molecular characteristics.To investigate apparent diffusion coefficient (ADC) as imaging biomarker glioma the 2021 World Health Organization (WHO) classification central nervous system (CNS)...
Purpose To demonstrate the feasibility of 129 Xe MR in evaluating pulmonary physiological changes caused by PM 2.5 animal models. Methods Six rats were treated with solution (16.2 mg/kg) intratracheal instillation twice a week for 4 weeks, and another six normal saline served as control cohort. Pulmonary function tests, hyperpolarized multi‐ b diffusion‐weighted imaging, chemical shift saturation recovery spectroscopy performed on all rats, structure functional parameters obtained from data....
Background Global brain health has gained increasing attention recently. Imaging markers of frailty have been related to functional outcomes in previous studies on anterior circulation; however, little data are available imaging and posterior circulation. Purpose To investigate the impact patients with acute perforating artery infarction (PAI) Study Type Prospective. Population One hundred (60.78 ± 9.51 years, 72% men) circulation PAI (determined by diffusion‐weighted magnetic resonance...
Background and purpose Individuals with intracranial artery occlusion have high rates of ischaemic events recurrence. It has been challenging to identify patients who had high-risk stroke using a simple, valid non-invasive screening approach. This study aimed investigate whether fluid-attenuated inversion recovery (FLAIR) vascular hyperintensity (FVH), specific imaging sign on the FLAIR sequence, could be predictor in population internal carotid (ICA) or middle cerebral (MCA) occlusion....
Abstract Objectives We aim to investigate whether cerebral small vessel disease (cSVD) imaging markers correlate with deep medullary vein (DMV) damage in occlusion acute ischemic stroke (SVO-AIS) patients. Methods The DMV was divided into six segments according the regional anatomy. total score (0–18) calculated based on segmental continuity and visibility. of grouped quartiles score. Neuroimaging biomarkers cSVD including white matter hyperintensity (WMH), microbleed (CMB), perivascular...
<h3>BACKGROUND AND PURPOSE:</h3> The ability of the ivy sign on contrast-enhanced T1-weighted MR imaging (CEMR) to reflect cerebral perfusion and postoperative revascularization in Moyamoya disease remains largely unknown. We aimed compare capabilities CEMR FLAIR. <h3>MATERIALS METHODS:</h3> CEMR, FLAIR, arterial spin-labeling, DSA were performed 44 patients with disease. was scored separately FLAIR using Alberta Stroke Program Early CT Score. status leptomeningeal collaterals DSA....
Abstract Aims To examine whether functional connectivity (FC) of the occipital gyrus differs between patients with Parkinson's disease (PD) motor subtypes and healthy controls (HCs). Methods We enrolled 30 PD exhibiting tremor dominance (TD), 43 postural instability gait disturbance (PIGD), 42 HCs. The was partitioned into six areas interest, as seed points, via Anatomical Automatic Labeling template to compare FC three groups analyze relationship clinical scales. Results Compared PIGD...
Background Arterial spin labeling (ASL) has shown potential for the assessment of penumbral tissue in patients with acute ischemic stroke (AIS). The postlabeling delay (PLD) parameter is sensitive to arterial transit delays and influences cerebral blood flow measurements. Purpose To assess impact ASL acquisition at different PLDs quantification compare their performance regarding assisting patient selection endovascular treatment dynamic susceptibility contrast MRI (DSC‐MRI) as reference...
Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is a rare neurodegenerative for which there no specific treatment. Very few cases have been treated with single-target deep brain stimulation (DBS), and the results were not satisfactory. We applied multi-target DBS to an SCA3/MJD patient performed positron emission computed tomography (PET) before after explore short-term clinical therapeutic effect.A 26-year-old right-hand-dominant female family history of...