A5038497002- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related gene regulation
- Genetic Syndromes and Imprinting
- Signaling Pathways in Disease
- Air Quality and Health Impacts
- Energy and Environment Impacts
- Heavy Metal Exposure and Toxicity
- Chromosomal and Genetic Variations
- Caveolin-1 and cellular processes
- Epigenetics and DNA Methylation
- Mycobacterium research and diagnosis
- Genomics and Phylogenetic Studies
- Ferroptosis and cancer prognosis
Guangzhou Medical University
2019-2025
First Affiliated Hospital of Guangzhou Medical University
2020-2024
State Key Laboratory of Respiratory Disease
2019-2024
Nanjing Medical University
2014-2017
Long non-coding RNA HOX transcript antisenseRNA (HOTAIR) has been widely identified to participate in tumour pathogenesis, acting as a promoter colorectal cancer carcinogenesis. However, the association between genetic variants HOTAIR and risk not yet reported. In present study, we performed two-stage case–control study investigate tagSNPs of cancer. We found that individuals with rs7958904 CC genotype had significantly decreased both Stage 1 2, compared those carrying GG [odds ratio (OR) =...
Fine particulate matter (PM2.5) is one of the most important components environmental pollutants, and associated with pulmonary injury. However, biological mechanisms damage caused by PM2.5 are poorly defined, especially molecular pathways related to inflammation. Following system exposure for 3 months in normal mice chronic obstructive disease (COPD) model mice, it was found that increased expression IL-1β IL-18 lung tissues via NLRP3 activation, these effects were more intense COPD mice....
The long non-coding RNA (lncRNA) H19 as an imprinted gene transcribed from only the maternal allele has vital role in carcinogenesis. Aberrant expression is involved bladder cancer development. In this study, we explored association between single nucleotide polymorphisms (SNPs) and risk. Four tagging SNPs (tagSNPs) were selected 1000 Genomes Project database. total, 1049 cases 1399 controls recruited case–control study. Odds ratios (ORs) corresponding 95% confidence intervals (CIs)...
Abstract Changes in gene expression lung epithelial cells are detected cancer tissues during exposure to pollutants, highlighting the importance of gene‐environmental interactions disease. Here, a Cd‐induced malignant transformation model mouse lungs and bronchial cell lines is constructed, differences non‐coding circRNAs analyzed. The migratory invasive abilities Cd‐transformed suppressed by circCIMT. A significant DNA damage response observed after Cd, which increased further following...
BACKGROUND PIWI‐interacting RNAs (piRNAs), which are a novel type of identified small noncoding RNA (ncRNA), play crucial role in germline development and carcinogenesis. METHODS By systematically screening all known piRNAs, the authors 7 common single nucleotide polymorphisms (SNPs) 9 piRNAs. Associations between these selected SNPs risk colorectal cancer (CRC) were detected case‐control study. A quantitative real‐time polymerase chain reaction assay was used to evaluate messenger (mRNA)...
// Yao Xue 1,2,* , Gaoxiang Ma Zhensheng Zhang 3,* Qiuhan Hua 1,2 Haiyan Chu 1 Na Tong Lin Yuan 4 Chao Qin 5 Changjun Yin Zhengdong and Meilin Wang Department of Environmental Genomics, Jiangsu Key Laboratory Cancer Biomarkers, Prevention Treatment, Center, Nanjing Medical University, Nanjing, China 2 Genetic Toxicology, The Modern Ministry Education, School Public Health, 3 Urology, Changhai Hospital, Second Military Shanghai, Province Hospital TCM, First Affiliated * These authors...
Abstract Some cancers are strongly associated with exposure to environmental carcinogens, and genetic epigenetic alterations crucial in carcinogenesis. However, the interaction between mutations regulation cancer development has not been sufficiently examined. Here, we investigated roles of gene altered circRNA expression malignant transformation human bronchial epithelial cells after continuous CdCl2 (10 μM). The circular RNA circ_0007095 was down-regulated, SETBP1-R54P single nucleotide...
Defects in the DNA damage response (DDR) are associated with tumorigenesis, and circular RNAs (circRNAs) can also affect occurrence progression of cancer by regulating gene expression. However, relationship between lung circRNAs remains unexplored. In this study, circ_0004470 was significantly upregulated various cells (H446, A549, H1299) as well carcinogenic animal models clinical samples. Circ_0004470 promoted cell cycle S phase arrest human pulmonary bronchial epithelial cells, inhibited...
Adverse health effects induced by neodymium oxide (Nd2O3) particles have raised concern as a result of their increasing applications in various arenas. However, information on potential cytotoxicity is currently limited. In the present study, we investigated underlying Nd2O3 human bronchial epithelial cells (16HBE) and mechanisms mediated circular RNAs (circRNAs). exposure initiated an inflammatory response 16HBE via release proinflammatory cytokines interleukin (IL)-6 IL-8. The...
Inactivation of tumor suppressor genes by promoter hypermethylation plays a key role in the tumorgenesis. It is necessary to uncover detailed pattern whole genome-wide abnormal DNA methylation during development gastric cancer (GC). We performed detection using 12 paired GC tissues and their corresponding normal tissues. Methylation-specific PCR (MSP) bisulphite sequencing (BSP) were used measure status specific CpG site. Based on bioinformatic analysis, cell phenotypes mouse model...
Exposure to environmental carcinogens is a significant contributor cancer development, with genetic and epigenetic alterations playing pivotal roles in the carcinogenic process. However, interplay between regulation changes carcinogenesis has yet receive comprehensive attention. This study investigates impact of continuous exposure tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on bronchial epithelial cells, leading malignant transformation. Our findings...
One of the most carcinogenic chemicals found in cigarette tobacco smoke is 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which has been confirmed to be associated with etiology diverse cancers. Lipopolysaccharide (LPS), another biologically active component smoke, a risk factor enhances NNK-induced lung tumorigenesis due chronic inflammation. Although inflammatory responses play critical roles initiation many tumors, our knowledge about mechanisms NNK+LPS on inflammation currently...
Abstract Cigarette smoking-induced chronic inflammation has been considered a vital driver of lung tumorigenesis. The compounds 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), tobacco-specific carcinogen, and lipopolysaccharide (LPS), an inflammatory inducer, are important components tobacco smoke which have implicated in inflammation-driven carcinogenesis. However, the biological effects underlying mechanisms LPS-mediated on NNK-induced tumorigenesis still unclear. In this study,...
Malignant Transformation of Cells Cadmium (Cd) exposure derived from air pollution and smoking may cause lung cancer. In article number 2206896, Lihua Huang, Yiguo Jiang, co-workers reveal the mechanism role circRNA in DNA damage repair during Cd-induced transformation epithelial cell. Cd affects binding circCIMT APEX1 protein, which further inhibited base excision repair, resulting accumulation promoting cancer occurrence. These findings provide significant insights into importance...